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公开(公告)号：EP4393420A1
公开(公告)日：2024-07-03
申请号：EP23200059.6
申请日：2023-09-27
发明人： Makino, Hodaka , Shioyama, Takahiro , Nakayama, Keiko , Sasaki, Tatsuya , Ogawa, Tetsuya , Shinozaki, Yukino , Suzuki, Akane , Akiyoshi, Hideo
IPC分类号： A61B17/34 , A61B17/3209 , A61B90/00
CPC分类号： A61B17/3468 , A61B2090/06220160201 , A61B17/32093
摘要： An implant device configured to implant an implantable member into a living body includes a receiving portion having an opening surface having an opening capable of receiving the implantable member, and a support surface configured to face the opening surface in a first direction and to support the implantable member, and a discharge portion having a discharge port configured to discharge the implantable member, and a communication passage configured to communicate the discharge port and the opening and extending in a second direction intersecting with the first direction.
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公开(公告)号：EP3239694A1
公开(公告)日：2017-11-01
申请号：EP17167028.4
申请日：2017-04-19
CPC分类号： C12Q1/6886 , G01N15/1429 , G01N15/1459 , G01N21/6428 , G01N21/6486 , G01N2015/1006 , G01N2015/1486 , G01N2015/1488 , G01N2021/6439
摘要： An apparatus and a method for diagnosing a tumor are provided. A histogram generating section (14) generates a histogram from a result of a measurement of fluorescence intensity of a suspension produced from a target sample. The histogram indicates a relation between the fluorescence intensity and the number of cells. A determination section (15) detects an S phase fluorescence intensity range corresponding to S phase cells based on the fluorescence intensity corresponding to a peak of the number of cells in the histogram, detects an abnormal fluorescence intensity range corresponding to tumor cells, based on a change in the number of cells in the S phase fluorescence intensity range, and performs a diagnosis of a tumor in the target sample based on an index of the number of cells in a range defined by excluding the abnormal fluorescence intensity range from the S phase fluorescence intensity range.
摘要翻译： 提供了一种诊断肿瘤的装置和方法。 直方图生成部分（14）根据由目标样本产生的悬浮液的荧光强度的测量结果生成直方图。 直方图表示荧光强度和细胞数量之间的关系。 判定部（15）基于与直方图中的细胞数的峰值对应的荧光强度，检测与S相细胞对应的S相荧光强度范围，根据该判定结果，检测与肿瘤细胞对应的异常荧光强度范围 改变S期荧光强度范围内的细胞数，并基于通过从S期荧光排除异常荧光强度范围而限定的范围内的细胞数目指标来执行目标样本中肿瘤的诊断 强度范围。
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3.发明公开Cell analyzing apparatus and cell analyzing method 审中-公开Zellanalysevorrichtung und Zellanalyseverfahren
公开(公告)号：EP2857828A1
公开(公告)日：2015-04-08
申请号：EP14185334.1
申请日：2014-09-18
发明人： Takeda, Sunao , Kubo, Hirotsugu , Shioyama, Takahiro , Suzuki, Akane , Nomura, Kenichi , Kato, Yo , Hinata, Nae
CPC分类号： G06K9/00127 , A61B5/0071 , G01N15/1429 , G01N15/1459 , G01N21/6428 , G01N2015/1006 , G01N2015/1402 , G01N2015/1486 , G01N2015/1488 , G01N2021/6439
摘要： A cell analyzing apparatus (1) includes: a first histogram acquiring section (11) which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section (12) which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section (14) which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section (15) which is configured to output a result of the determination performed by the determining section.
摘要翻译： 细胞分析装置（1）包括：第一直方图获取部（11），其被配置为通过使用核染色细胞的数量的测量结果来获取荧光强度的第一直方图; 第二直方图获取部（12），其被配置为获取基于指示所述第一直方图的最大值的荧光强度值被归一化的第二直方图; 基于所述第一直方图和所述第二直方图之一，被配置为确定是否存在癌细胞的确定部分（14）; 以及输出部（15），其被配置为输出由所述确定部执行的所述确定的结果。
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公开(公告)号：EP2685402B1
公开(公告)日：2020-10-07
申请号：EP13172143.3
申请日：2013-06-14
发明人： Takeda, Sunao , Shioyama, Takahiro , Suzuki, Akane , Kato, Yo , Hinata, Nae
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公开(公告)号：EP2423301B1
公开(公告)日：2017-10-18
申请号：EP11178751.1
申请日：2011-08-25
发明人： Haraguchi, Yuji , Shimizu, Tatsuya , Okano, Teruo , Shioyama, Takahiro , Suzuki, Akane , Takeda, Sunao
CPC分类号： G01N1/286 , C12M41/02 , C12M45/02 , C12M47/04 , G01N2001/2866
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公开(公告)号：EP3239694B1
公开(公告)日：2019-05-22
申请号：EP17167028.4
申请日：2017-04-19
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公开(公告)号：EP2423662A2
公开(公告)日：2012-02-29
申请号：EP11178659.6
申请日：2011-08-24
发明人： Suzuki, Akane , Shioyama, Takahiro , Takeda, Sunao
CPC分类号： G01N1/286 , G01N1/38 , G01N15/14 , G01N2001/085 , G01N2001/2866
摘要： A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured by a bottomed pipe in which a first hole that communicates an interior with an exterior is formed, and that is fitted to a bottom portion of the cylinder member in a state where the net and the tissue acquiring unit are accommodated.
摘要翻译： 细胞分离装置包括：插入待引入试剂的容器中的圆筒部件; 一个在气缸构件上伸展的网; 组织获取单元，其从所述圆筒构件突出; 以及底盖部，其由形成有与内部连通的第一孔的有底管构成，并且在所述网和所述组织获取单元的状态下嵌合在所述筒构件的底部， 被容纳。
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公开(公告)号：EP3192450A1
公开(公告)日：2017-07-19
申请号：EP16207519.6
申请日：2016-12-30
发明人： Suzuki, Akane , Shioyama, Takahiro
CPC分类号： A61B10/06 , A61B10/0096 , A61B17/30 , B01L3/502 , B01L3/5082 , B01L3/50825 , B01L2300/041 , B01L2300/046 , B01L2300/0681 , B01L2300/0832 , B01L2300/0858 , B01L2300/123
摘要： Provided is a cell isolation instrument (10) capable of smoothly performing a plurality of steps (gripping of a biological tissue, transfer, and isolation) associated with isolation of cells.
A container (11) has an opening. A sealing member (12) seals the opening. A pair of pinching parts (13a, 13b) is connected to the sealing member (12) and is configured to be openable or closable by pressing.摘要翻译： 本发明提供一种细胞分离装置（10），该细胞分离装置（10）能够顺利地进行与分离细胞相关联的多个步骤（抓住生物组织，转移和分离）。 容器（11）具有开口。 密封构件（12）密封开口。 一对夹持部件（13a，13b）连接到密封部件（12），并且构造成通过按压而可打开或可关闭。
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公开(公告)号：EP2685402A3
公开(公告)日：2016-11-09
申请号：EP13172143.3
申请日：2013-06-14
发明人： Takeda, Sunao , Shioyama, Takahiro , Suzuki, Akane , Kato, Yo , Hinata, Nae
摘要： A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis.
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公开(公告)号：EP2674481A1
公开(公告)日：2013-12-18
申请号：EP13170633.5
申请日：2013-06-05
摘要： A cell isolation apparatus in which tissue and fluid that are accommodated in a container are pipetted by a pipette, and cells are isolated from the tissue, the cell isolation apparatus includes: a nozzle to which the pipette is attached; a pump which is connected to the nozzle; a controller which is configured to control an operation of the pump to cause air to be ejected from the nozzle or to be sucked into the nozzle, thereby causing the pipette to perform pipetting; and a condition inputting unit in which a user inputs a condition of control of the controller,
摘要翻译： 一种细胞分离装置，其中容纳在容器中的组织和流体由移液管吸移，并且细胞与组织分离，细胞分离装置包括：吸附器附着的喷嘴; 连接到喷嘴的泵; 控制器，其被配置为控制所述泵的操作以使空气从所述喷嘴喷射或被吸入所述喷嘴，从而使所述移液管进行移液; 以及条件输入单元，其中用户输入控制器的控制条件，
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