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1.发明授权
公开(公告)号：EP2155670B1
公开(公告)日：2012-04-18
申请号：EP08760484.9
申请日：2008-06-04
申请人： Novartis AG
IPC分类号： C07D207/09 , C07D307/14 , A61K31/341
CPC分类号： C07D207/09 , C07D307/14
摘要： The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof.
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2.发明公开5-SULFANYLMETHYL-[1,2,4] TRIAZOL[1, 5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS 有权5-硫烷基 - [1,2,4]三唑并[1,5-a]嘧啶-7- OLDERIVATE AS CXCR2拮抗剂
公开(公告)号：EP2094696A1
公开(公告)日：2009-09-02
申请号：EP07819889.2
申请日：2007-11-21
申请人： NOVARTIS AG
发明人： PRESS, Neil John , PORTER, David , SPANKA, Carsten
IPC分类号： C07D471/04 , A61K31/522 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.
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公开(公告)号：EP2257552A1
公开(公告)日：2010-12-08
申请号：EP09714437.2
申请日：2009-02-25
申请人： Novartis AG
IPC分类号： C07D487/04 , A61K31/519 , A61P37/06
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) wherein R
1 , R
2 , X, Y and Z are as defined in the specification.-
4.发明授权5-SULFANYLMETHYL-[1,2,4] TRIAZOL[1, 5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS 有权5-硫烷基 - [1,2,4]三唑并[1,5-a]嘧啶-7- OLDERIVATE AS CXCR2拮抗剂
公开(公告)号：EP2094696B1
公开(公告)日：2010-10-13
申请号：EP07819889.2
申请日：2007-11-21
申请人： Novartis AG
发明人： PRESS, Neil John , PORTER, David , SPANKA, Carsten
IPC分类号： C07D471/04 , A61K31/522 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.
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公开(公告)号：EP1983985A1
公开(公告)日：2008-10-29
申请号：EP07703104.5
申请日：2007-01-29
申请人： NOVARTIS AG
发明人： McCARTHY, Clive , PRESS, Neil John
IPC分类号： A61K31/4375 , A61P9/00 , A61P11/00
CPC分类号： A61K31/4375
摘要： Compounds of formula (I) in free or salt form for the preparation of a medicament for the treatment of pulmonary hypertension, where R1 and R2 have the meanings as indicated in the specification. Pharmaceutical compositions that contain the compounds are also described.
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公开(公告)号：EP2310359A1
公开(公告)日：2011-04-20
申请号：EP09804555.2
申请日：2009-08-03
申请人： Novartis AG
IPC分类号： C07C311/48 , C07D231/12 , C07D213/36 , C07D243/08 , C07D261/08 , C07D307/14 , C07D307/52 , C07D333/36 , C07D413/12 , A61K31/18 , A61P29/00
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
摘要： The present invention relates to compounds of Formula (I) wherein X, R
1 , R
2 , R
3 , R
4 and R
5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.摘要翻译： 本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义，其可用于治疗对CXCR2受体介导物有反应的疾病。 还描述了含有用于制备该化合物的化合物和方法的药物组合物。
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公开(公告)号：EP2155670A1
公开(公告)日：2010-02-24
申请号：EP08760484.9
申请日：2008-06-04
申请人： Novartis AG
IPC分类号： C07D207/09 , C07D307/14 , A61K31/341
CPC分类号： C07D207/09 , C07D307/14
摘要： The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof.
摘要翻译： 本发明涉及具有本文定义的取代基的式（I）化合物及其用途。
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公开(公告)号：EP2086947A1
公开(公告)日：2009-08-12
申请号：EP07819888.4
申请日：2007-11-21
申请人： NOVARTIS AG
发明人： PRESS, Neil John , HUNT, Peter , PORTER, David , JANUS, Diana
IPC分类号： C07D239/56 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/513 , A61P11/00
CPC分类号： C07D239/56 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.
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公开(公告)号：EP2310359B1
公开(公告)日：2014-01-15
申请号：EP09804555.2
申请日：2009-08-03
申请人： Novartis AG
IPC分类号： C07C311/48 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D333/36 , C07D413/12 , A61K31/18 , A61P29/00
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
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公开(公告)号：EP1910314B1
公开(公告)日：2010-09-15
申请号：EP06762705.9
申请日：2006-07-19
申请人： Novartis AG
IPC分类号： C07D235/30 , C07D401/12 , C07D403/04 , C07D405/12 , A61K31/4184 , A61K31/4439 , A61P11/08
CPC分类号： C07D405/12 , C07D235/30 , C07D401/12 , C07D403/04
摘要： Benzimidazole derivatives, methods of preparing the same and their pharmaceutical uses for the treatment of inflammatory diseases including COPD.
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