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公开(公告)号：EP1408884A1
公开(公告)日：2004-04-21
申请号：EP02753372.8
申请日：2002-07-12
申请人： Osteotech, Inc., , Kaes, David R. , Morris, John W. , Shimp, Lawrence A. , Winterbottom, John , Geisler, Fred
CPC分类号： A61F2/28 , A61B17/86 , A61F2/30965 , A61F2/4455 , A61F2/446 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30131 , A61F2002/30176 , A61F2002/30354 , A61F2002/30405 , A61F2002/30492 , A61F2002/30578 , A61F2002/30677 , A61F2002/30777 , A61F2002/30785 , A61F2002/30836 , A61F2002/30841 , A61F2002/3085 , A61F2002/30904 , A61F2002/4475 , A61F2002/449 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0054 , A61F2310/00017 , A61F2310/00023 , A61F2310/00131 , A61F2310/00293 , A61F2310/00365
摘要： An implant unit used in surgery has a body made from osteogenic implantable material and including an implant portion and a retaining portion, which is coupled to and extends transversely to the implant portion. The retaining portion is attached to the sidewall of the adjoining vertebral body or mammal bone to prevent displacement of the implant portion relative to the vertebral body or mammal bone and to accelerate fusion therebetween.
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公开(公告)号：EP1981440A2
公开(公告)日：2008-10-22
申请号：EP07718273.1
申请日：2007-01-19
申请人： Osteotech, Inc.,
CPC分类号： A61L27/18 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K31/785 , A61L27/46 , A61L27/48 , C08G18/10 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04 , C08G18/36
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：EP2254649A1
公开(公告)日：2010-12-01
申请号：EP08873572.5
申请日：2008-12-24
申请人： Osteotech, Inc.,
发明人： WEI, Guobao , BEHNAM, Keyvan , FORSYTH, Nanette , WINTERBOTTOM, John , BEISSER, James , BOYCE, Todd, M. , ATTAWIA, Mohamed , RICHARDS, Cristy, J. , SHIMP, Lawrence
IPC分类号： A61M37/00
CPC分类号： A61M35/00
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
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公开(公告)号：EP1976459A2
公开(公告)日：2008-10-08
申请号：EP07718026.3
申请日：2007-01-19
申请人： Osteotech, Inc.,
发明人： SHIMP, Larry , WINTERBOTTOM, John , KAES, David, R. , BELANEY, Ryan, M. , BHATTACHARYYA, Subhabrata
IPC分类号： A61F2/28
CPC分类号： A61L27/56 , A61F2/28 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46
摘要： The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
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5.发明公开BIOIMPLANT WITH NONUNIFORMLY CONFIGURED PROTRUSIONS ON THE LOAD BEARING SURFACES THEREOF 审中-公开对于NOT配置相同的射影受影响地区的生物植入物
公开(公告)号：EP1631183A2
公开(公告)日：2006-03-08
申请号：EP04754204.8
申请日：2004-06-03
申请人： Osteotech, Inc.
IPC分类号： A61B1/00
CPC分类号： A61F2/30771 , A61F2/4455 , A61F2002/2835 , A61F2002/30059 , A61F2002/30113 , A61F2002/30125 , A61F2002/30131 , A61F2002/30136 , A61F2002/30151 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/30159 , A61F2002/30205 , A61F2002/30224 , A61F2002/30263 , A61F2002/30273 , A61F2002/30828 , A61F2002/30879 , A61F2002/30892 , A61F2002/4649 , A61F2230/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0028 , A61F2230/0067 , A61F2230/0069 , A61F2230/0084 , A61F2230/0086 , A61F2310/00293
摘要： A bioimplant is configured with at least two load-bearing surfaces (12, 14) each having a plurality of protrusions (16, 18) oriented at an angle with respect to one another to resist translation in all directions when opposing load bearing surfaces are under normally applied compressive loads.
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公开(公告)号：EP1434608A2
公开(公告)日：2004-07-07
申请号：EP02773762.6
申请日：2002-10-15
申请人： Osteotech, Inc.
CPC分类号： A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61L27/227 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/505 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2430/02 , B33Y80/00
摘要： The invention provides an osteoinductive composition for implantation at a bone defect site which comprises osteoinductive demineralized bone matrix in a carrier of hydrated polysaccharide, the type and quantity of polysaccharide present in the carrier being sufficient, upon hydration, of importing flowability to the composition and providing an osteoinductive activity of at least 1 as measured by the athymic rat model assay. The polysaccharide may be selected from the group consisting of starch and cellulose.
摘要翻译： 本发明提供一种用于植入骨缺损部位的骨诱导性组合物，其包含在水合多糖的载体中的骨诱导脱矿质骨基质，载体中存在的多糖的类型和数量在水合时足以向组合物输入流动性并提供 通过无胸腺大鼠模型测定测量的至少1的骨诱导活性。 多糖可以选自淀粉和纤维素。
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公开(公告)号：EP1976460A2
公开(公告)日：2008-10-08
申请号：EP07718335.8
申请日：2007-01-19
申请人： Osteotech, Inc.,
发明人： WINTERBOTTOM, John , KAES, David, R. , TUNC, Deger, C. , BOYCE, Todd, M. , KNAACK, David , RUSSELL, James , BHATTACHARYYA, Subhabrata
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
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公开(公告)号：EP1439802A2
公开(公告)日：2004-07-28
申请号：EP02778655.7
申请日：2002-10-28
申请人： Osteotech, Inc.
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/2816 , A61B17/282 , A61B17/2833 , A61B2017/2845 , A61F2/28 , A61F2/442 , A61F2/4465 , A61F2/4611 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30131 , A61F2002/30153 , A61F2002/302 , A61F2002/3023 , A61F2002/30235 , A61F2002/30772 , A61F2002/30774 , A61F2002/30789 , A61F2002/3082 , A61F2002/30904 , A61F2002/4475 , A61F2002/448 , A61F2002/4622 , A61F2002/4623 , A61F2002/4627 , A61F2002/4628 , A61F2002/4649 , A61F2002/4681 , A61F2230/0013 , A61F2230/0019 , A61F2230/0065 , A61F2230/0069 , A61F2310/00023
摘要： Spinal and other implants may be bone or synthetic material shaped as rings, C-shaped or rectangular and so on. The implants have one or more recesses aligned in an insertion direction at either or both outer peripheral sides of the implant. In a ring implant, e.g., formed from a transverse slice of the diaphysis of a long bone or otherwise, the recesses are aligned overlying the opposing sides of the ring parallel to the insertion direction, which sides are stronger than the more central region overlying and aligned with a central chamber in the implant. One or two spaced recesses on opposite sides (150) of an implant have surface(s) transverse to the insertion direction receive the tips of implant insertion gripping jaws for receiving an insertion load imparted by the tips.
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