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公开(公告)号：EP4431598A2
公开(公告)日：2024-09-18
申请号：EP24188307.3
申请日：2018-11-23
发明人： DIALLO, Jean-Simon , SELMAN, Mohammed , ARULANANDAM, Rozanne , FORBES, Nicole Elise , KRISHNA, Ramya
IPC分类号： C12N7/00
CPC分类号： A61K31/225 , C07C69/60 , C12N7/00 , A61P35/00 , C12N2710/1033220130101 , C12N2710/1035120130101 , C12N2740/1604320130101 , C12N2760/1613420130101 , C12N2760/1615120130101 , C12N2760/2023220130101 , C12N2760/2025120130101 , Y02A50/30
摘要： Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
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公开(公告)号：EP3250550A1
公开(公告)日：2017-12-06
申请号：EP16742609.7
申请日：2016-01-26
发明人： DIALLO, Jean-Simon , BODDY, Christopher Noyce , DORNAN, Mark , KRISHNAN, Ramya , ARULANANDAM, Rozanne , LE BOEUF, Fabrice , SMITH, Jeffrey , MACKLIN, Andrew
IPC分类号： C07D207/38 , A61P31/12 , A61P37/04 , C07D237/14 , C07D307/60 , C07D307/66 , C12N5/00 , C12N5/07 , C12N7/00
CPC分类号： C12N7/00 , A61K31/4015 , A61K31/402 , C07D207/36 , C07D207/38 , C07D207/456 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：EP3008176A1
公开(公告)日：2016-04-20
申请号：EP14811047.1
申请日：2014-06-16
发明人： ILKOW, Carolina Solange , LEBOEUF, Fabrice , BELL, John Cameron , DIALLO, Jean-simon , ARULANANDAM, Rozanne
CPC分类号： C12N7/00 , A61K35/76 , A61K35/766 , A61K35/768 , A61K38/1793 , A61K38/1825 , C07K14/50 , C07K2319/02 , C12N2710/16651 , C12N2710/24151 , C12N2720/12051 , C12N2760/16151 , C12N2760/16152 , C12N2760/18451 , C12N2760/18452 , C12N2760/20232 , C12N2760/20251 , Y02A50/385 , Y02A50/393 , Y02A50/465 , A61K2300/00
摘要： Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.
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4.发明公开
公开(公告)号：EP4219457A1
公开(公告)日：2023-08-02
申请号：EP23164084.8
申请日：2016-01-26
发明人： DIALLO, Jean-Simon , BODDY, Christopher Noyce , DORNAN, Mark , KRISHNAN, Ramya , ARULANANDAM, Rozanne , LE BOEUF, Fabrice , SMITH, Jeffrey , MACKLIN, Andrew
IPC分类号： C07D237/14 , A61P31/12 , A61P37/04 , A61K31/4015 , A61K31/402 , C12N5/00 , C12N5/07 , C12N7/00
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：EP3714044A1
公开(公告)日：2020-09-30
申请号：EP18880792.9
申请日：2018-11-23
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