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1.发明公开
公开(公告)号：EP4219457A1
公开(公告)日：2023-08-02
申请号：EP23164084.8
申请日：2016-01-26
发明人： DIALLO, Jean-Simon , BODDY, Christopher Noyce , DORNAN, Mark , KRISHNAN, Ramya , ARULANANDAM, Rozanne , LE BOEUF, Fabrice , SMITH, Jeffrey , MACKLIN, Andrew
IPC分类号： C07D237/14 , A61P31/12 , A61P37/04 , A61K31/4015 , A61K31/402 , C12N5/00 , C12N5/07 , C12N7/00
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：EP3250550A1
公开(公告)日：2017-12-06
申请号：EP16742609.7
申请日：2016-01-26
发明人： DIALLO, Jean-Simon , BODDY, Christopher Noyce , DORNAN, Mark , KRISHNAN, Ramya , ARULANANDAM, Rozanne , LE BOEUF, Fabrice , SMITH, Jeffrey , MACKLIN, Andrew
IPC分类号： C07D207/38 , A61P31/12 , A61P37/04 , C07D237/14 , C07D307/60 , C07D307/66 , C12N5/00 , C12N5/07 , C12N7/00
CPC分类号： C12N7/00 , A61K31/4015 , A61K31/402 , C07D207/36 , C07D207/38 , C07D207/456 , C07D237/14 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/66 , C07D317/64 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04 , C12N2710/10334 , C12N2710/10351 , C12N2710/10352 , C12N2710/16651 , C12N2710/24151 , C12N2750/14151 , C12N2760/16134 , C12N2760/16151 , C12N2760/16152 , C12N2760/20234 , C12N2760/20251 , C12N2760/20252
摘要： Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.
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公开(公告)号：EP3735467A1
公开(公告)日：2020-11-11
申请号：EP19736225.4
申请日：2019-01-04
发明人： BELL, John C. , LE BOEUF, Fabrice , HUH, Michael S. , TANG, Matthew Y. , KELLER, Brian Andrew , PELIN, Adrian
IPC分类号： C12N15/863 , A61K35/76 , A61K35/768 , A61P35/00 , C07K14/07 , C12N15/39 , C12N5/10 , C12N7/01
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公开(公告)号：EP4137578A1
公开(公告)日：2023-02-22
申请号：EP22175898.0
申请日：2019-01-04
发明人： BELL, John , LE BOEUF, Fabrice , HUH, Michael S. , TANG, Matthew Y. , KELLER, Brian Andrew , PELIN, Adrian
IPC分类号： C12N15/863 , A61K35/76 , A61K35/768 , A61P35/00 , C07K14/07 , C12N15/39 , C12N5/10 , C12N7/01
摘要： The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.
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公开(公告)号：EP2349296A1
公开(公告)日：2011-08-03
申请号：EP09807799.3
申请日：2009-08-20
发明人： BELL, John C. , LE BOEUF, Fabrice
CPC分类号： A61K38/162 , A61K35/76 , A61K35/766 , A61K38/193 , C12N2710/24132 , C12N2760/20232 , A61K2300/00
摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.
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公开(公告)号：EP3735466A1
公开(公告)日：2020-11-11
申请号：EP19736067.0
申请日：2019-01-04
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公开(公告)号：EP2349296B1
公开(公告)日：2017-04-05
申请号：EP09807799.3
申请日：2009-08-20
发明人： BELL, John C. , LE BOEUF, Fabrice
IPC分类号： A61K35/76 , A61P35/00 , A61K35/766
CPC分类号： A61K38/162 , A61K35/76 , A61K35/766 , A61K38/193 , C12N2710/24132 , C12N2760/20232 , A61K2300/00
摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.
摘要翻译： 一方面，本发明提供了通过用两种或多种病毒株感染宿主组织来优先杀死宿主例如癌细胞中的靶增殖细胞的方法。 可以选择病毒株以提供协同和共生作用，其涉及目标增殖细胞中的同时溶解感染。 在选择的实施方案中，选择病毒使得第一毒力因子在被第一病毒感染的增殖细胞中的表达增加了第二病毒的溶解作用; 并且第二种毒力因子在用第二种病毒感染的增殖细胞中的表达增加了第一种病毒的溶解作用。 可以选择第一和第二病毒的基因组，使得它们与宿主细胞中的病毒基因组之间的重组不相容。
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8.发明授权COMPOSITIONS AND USES FOR ENHANCING VIRUS PRODUCTION 有权ZUSAMMENSETZUNGEN UND VERWENDUNGEN ZURERHÖHUNGDER VIRUSPRODUKTION
公开(公告)号：EP2451795B1
公开(公告)日：2016-07-13
申请号：EP10796623.6
申请日：2010-07-07
IPC分类号： A61K31/341 , A61K35/76 , A61K45/06 , C12N7/00 , A61P35/00
CPC分类号： A61K35/766 , A61K31/275 , A61K31/341 , A61K31/365 , A61K38/00 , A61K45/06 , C07C49/675 , C07C49/747 , C07C205/37 , C07C217/84 , C07C233/32 , C07C233/38 , C07C243/38 , C07C255/37 , C07C311/44 , C07C323/42 , C07C323/60 , C07C335/16 , C07C337/06 , C07C337/08 , C07C2601/02 , C07C2601/14 , C07C2603/26 , C07C2603/34 , C07D213/75 , C07D233/90 , C07D257/04 , C07D307/58 , C07D319/20 , C07D333/04 , C07D403/12 , C07D409/12 , C12N7/00 , C12N2760/20232 , C12N2760/20251 , A61K2300/00
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