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公开(公告)号：EP0710240B1
公开(公告)日：1996-12-18
申请号：EP94922935.5
申请日：1994-07-19
发明人： JACQUESY, Jean-Claude , FAHY, Jacques , BERRIER, Christian , BIGG, Dennis , JOUANNETAUD, Marie-Paule , ZUNINO, Fabien , KRUCZYNSKI, Anna , KISS, Robert
IPC分类号： C07D519/04 , A61K31/475
CPC分类号： C07D519/04
摘要： Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of said compounds in therapy and their methods of preparation.
摘要翻译： 通式（1）的长春碱和长春瑞滨家族的新型氟化衍生物和这些分子的治疗可接受的盐。 本发明还涉及所述化合物在治疗中的应用及其制备方法。
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公开(公告)号：EP0710240A1
公开(公告)日：1996-05-08
申请号：EP94922935.0
申请日：1994-07-19
发明人： JACQUESY, Jean-Claude , FAHY, Jacques , BERRIER, Christian , BIGG, Dennis , JOUANNETAUD, Marie-Paule , ZUNINO, Fabien , KRUCZYNSKI, Anna , KISS, Robert
CPC分类号： C07D519/04
摘要： Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1) and the therapeutically acceptable salts of these molecules. The invention also concerns the application of said compounds in therapy and their methods of preparation.
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公开(公告)号：EP2324031A1
公开(公告)日：2011-05-25
申请号：EP09781165.7
申请日：2009-07-28
IPC分类号： C07D491/04 , A61K31/473 , A61K31/4525
CPC分类号： C07D491/056 , A61K31/4741 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/664 , A61K31/704 , A61K31/7056 , A61K31/7076 , A61K33/24 , A61K38/12 , A61K38/50 , C07D491/04
摘要： The present invention concerns nitrogenated derivatives of narciclasine and pancratistatin of the following general formula (I) as well as their pharmaceutically acceptable salts. The present invention also concerns the use of these compounds in cancer therapy as well as a method for their preparation.
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4.发明公开
公开(公告)号：EP2321323A1
公开(公告)日：2011-05-18
申请号：EP09802516.6
申请日：2009-07-29
申请人： Pierre Fabre Medicament , Centre National de la Recherche Scientifique (C.N.R.S) , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , FOURNIAL, Anaïs , MORDANT, Céline , FAHY, Jacques
IPC分类号： C07D493/18 , A61K31/357 , A61P35/00
CPC分类号： C07D493/18 , C07D519/00
摘要： The present invention relates to dimeric derivatives of 10-trifluoromethylated artemisinin of formula (I) below: Formula (I) and the pharmaceutically acceptable salts thereof, and also to the preparation method thereof and to the uses thereof, especially in the treatment of cancer.
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5.发明授权
公开(公告)号：EP2321323B1
公开(公告)日：2013-05-29
申请号：EP09802516.6
申请日：2009-07-29
申请人： Pierre Fabre Medicament , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , FOURNIAL, Anaïs , MORDANT, Céline , FAHY, Jacques
IPC分类号： C07D493/18 , A61K31/357 , A61P35/00
CPC分类号： C07D493/18 , C07D519/00
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6.发明公开
公开(公告)号：EP2235022A1
公开(公告)日：2010-10-06
申请号：EP08864687.2
申请日：2008-12-22
申请人： Pierre Fabre Medicament , Centre National de la Recherche Scientifique - CNRS , UNIVERSITE PARIS-SUD 11
发明人： BEGUE, Jean-Pierre , BONNET-DELPON, Danièle , CROUSSE, Benoît , GRELLEPOIS, Fabienne , CHOLLET, Constance , FAHY, Jacques , MORDANT, Céline
IPC分类号： C07D493/18 , A61K31/35 , A61K31/357
CPC分类号： C07D519/00 , C07F9/6561
摘要： The present invention relates to dimeric derivatives of 10-trifluoromethylated artemisinin of formula (I) : or a pharmaceutically acceptable salt thereof with B1 and B2 selected from C=O, CHOH and CH2, as well as to their use in treating cancer and to their preparation method.
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公开(公告)号：EP0975640B1
公开(公告)日：2004-06-30
申请号：EP98920607.3
申请日：1998-04-10
发明人： DUFLOS, Alain , FAHY, Jacques , THILLAYE DU BOULAY, Valérie , BARRET, Jean-Marc , HILL, Bridget
IPC分类号： C07D519/04 , A61K31/395
CPC分类号： C07D519/04
摘要： The invention concerns novel halogenated derivatives of the vinblastine and vinorelbine family, corresponding to general formula (1) and their therapeutically acceptable salts. The invention also concerns the application of these compounds in therapy and their methods of preparation. The invention further concerns a novel method for preparing vinflunine or 20',20'-difluoro-3',4'-dihydrovinorelbine, of formula (a).
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公开(公告)号：EP0975640A1
公开(公告)日：2000-02-02
申请号：EP98920607.3
申请日：1998-04-10
发明人： DUFLOS, Alain , FAHY, Jacques , THILLAYE DU BOULAY, Valérie , BARRET, Jean-Marc , HILL, Bridget
IPC分类号： C07D519/04 , A61K31/395
CPC分类号： C07D519/04
摘要： The invention concerns novel halogenated derivatives of the vinblastine and vinorelbine family, corresponding to general formula (1) and their therapeutically acceptable salts. The invention also concerns the application of these compounds in therapy and their methods of preparation. The invention further concerns a novel method for preparing vinflunine or 20',20'-difluoro-3',4'-dihydrovinorelbine, of formula (a).
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