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公开(公告)号：EP1128849A1
公开(公告)日：2001-09-05
申请号：EP99967099.5
申请日：1999-11-08
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
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公开(公告)号：EP1128849B1
公开(公告)日：2007-02-07
申请号：EP99967099.5
申请日：1999-11-08
发明人： MILLS, C., Randal , WIRONEN, John, F. , HANSTKE, Sean , DONDA, Russel, S. , GROOMS, Jamie, M. , BIANCHI, John, R.
IPC分类号： A61L2/00 , A61L2/025 , A61L101/02 , A61L101/06 , A61L101/20 , A61L101/22 , A61L101/32 , A61L101/34 , A61L101/36 , A61L101/38 , A61L101/40 , A61L101/54
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
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公开(公告)号：EP1244477A2
公开(公告)日：2002-10-02
申请号：EP00989587.1
申请日：2000-12-29
IPC分类号： A61L24/00
CPC分类号： A61J1/2096 , A61F2/4601 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61F2002/4685 , A61J1/201 , A61J1/2058 , A61J1/2062 , A61J1/2089 , A61L24/0005 , A61L24/0094 , A61L27/3604 , A61L27/48 , B01F5/0685 , B01F11/0082 , B01F13/002 , B01F13/0023 , B01F15/00506 , B01F15/0201 , B01F15/0225 , B01F2215/0029
摘要： Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes.
摘要翻译： 本文公开了用于重构骨浆的有效且成本有效的系统，其包括含有重构流体的第一注射器和含有糊剂组分的第二注射器，其中所述第一注射器和第二注射器可连通地互连。 还公开了用于生产和储存骨浆的新型方法。
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公开(公告)号：EP1202755A1
公开(公告)日：2002-05-08
申请号：EP00952271.5
申请日：2000-07-28
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30756 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30235 , A61F2002/30772 , A61F2002/30774 , A61F2002/30813 , A61F2002/30841 , A61F2002/30866 , A61F2002/30892 , A61F2002/448 , A61F2230/0069 , A61K48/00 , A61L27/227 , A61L27/3608 , A61L27/3612 , A61L27/3645 , A61L27/54 , A61L2300/258 , A61L2300/412 , A61L2430/40
摘要： The present invention relates to tissues, including but not limited to bone and cartilage implants, as carrier matrices for delivery of biologically active nucleic acids to sites where such tissues are to be implanted. Upon implantation, the nucleic acids associated with the implants are taken up by cells within the implant site and are expressed, to produce growth factors, regenerative factors and the like encoded by the nucleic acids. In this manner, for example, where the nucleic acid encodes bone morphogenetic protein or the like, the rate of bone induction, conduction of healing and the rate of cartilage formation or repair is enhanced, without the attendant need to manufacture, purify, isolate and deliver protein or peptide growth factors.
摘要翻译： 本发明涉及组织，包括但不限于骨和软骨植入物，作为载体基质，用于将生物活性核酸递送至要植入组织的部位。 植入后，与植入物相关的核酸被植入部位内的细胞摄取并被表达，以产生由核酸编码的生长因子，再生因子等。 以这种方式，例如，在核酸编码骨形态发生蛋白等的情况下，增强了骨诱导率，愈合传导率和软骨形成或修复的速率，而无需伴随制造，纯化，分离和 递送蛋白质或肽生长因子。
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公开(公告)号：EP1181060A1
公开(公告)日：2002-02-27
申请号：EP00917954.0
申请日：2000-03-14
发明人： WIRONEN, John, F. , HORN, Jeffrey , KAO, Penelope
IPC分类号： A61L2/00
摘要： An implant and a method for making and using the implant are disclosed for the repair of bone defects or voids, including defects or voids in the acetabular cup. The implant shapes and compositions of this invention provide advantages not present in impaction grafts and like implants known in the art.
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公开(公告)号：EP1427322A2
公开(公告)日：2004-06-16
申请号：EP02757406.0
申请日：2002-08-27
IPC分类号： A61B1/00
CPC分类号： A61B17/1637 , A61B17/1671 , A61B17/8645 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30131 , A61F2002/30133 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30962 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0013 , A61F2230/0015 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0082 , A61L24/0005 , A61L27/3604 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/365 , A61L27/3658 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L31/005 , A61L2430/02 , A61L2430/34 , A61L2430/40
摘要： Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.
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公开(公告)号：EP1359951A2
公开(公告)日：2003-11-12
申请号：EP02720893.3
申请日：2002-01-25
发明人： WIRONEN, John, F.
CPC分类号： A61L27/56 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/30011 , A61F2002/30062 , A61F2002/30968 , A61F2210/0004 , A61F2250/0023 , A61F2310/00293 , A61F2310/00329 , A61L27/10 , A61L27/12 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2400/06 , A61L2430/02
摘要： A bone-like implant capable of increasing its porosity in situ comprising at least one bone-like compound with at least one hydrophobic carrier, or a degradable component. The bone-like implant includes its manufacture and methods of use. One aspect of the bone-like implant is to provide a method of repairing a bone defect or related injuries. The bone-like implant includes several embodiements capable of increasing its porosity in situ.
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