-
公开(公告)号：EP1762202A2
公开(公告)日：2007-03-14
申请号：EP06017261.6
申请日：1998-08-27
发明人： Carter, Kevin C. , Sander, Tom
IPC分类号： A61F2/44
CPC分类号： A61F2/4644 , A61F2/3094 , A61F2/442 , A61F2/4455 , A61F2002/2835 , A61F2002/2839 , A61F2002/30187 , A61F2002/30828 , A61F2002/30879 , A61F2002/4475 , A61F2002/448 , A61F2002/4649 , A61F2230/0034 , Y10T29/49947
摘要： The present invention relates to at least one implant consisting substantially of cortical bone, said implant comprising a canal surrounded by a continuous wall of cortical bone in the shape of a half circle, an half ellipse, or half asymmetrical shape, thereby forming an implant having a top face and a bottom face, either of which is substantially planar, with said planes being substantially parallel to each other.
摘要翻译： 本发明涉及至少一种基本上由皮质骨组成的植入物，所述植入物包括由半圆形，半椭圆形或半不对称形状的皮质骨连续壁围绕的管道，从而形成具有 顶面和底面，它们中的任一个基本上是平面的，并且所述平面基本上彼此平行。
-
公开(公告)号：EP1755379A1
公开(公告)日：2007-02-28
申请号：EP04822010.7
申请日：2004-04-20
发明人： MILLS, C., Randal , ROBERTS, Michael, R. , BIANCHI, John, R. , NATARAJ, Chandrasekaran , ZINGARO, Michael, J. , LEWIS, Wesley, I. , SANDERS, Benjamin, R.
IPC分类号： A01N1/02
CPC分类号： A61L2/0088
摘要： The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.
-
公开(公告)号：EP1779868A3
公开(公告)日：2007-11-14
申请号：EP07002028.4
申请日：1999-11-08
IPC分类号： A61L2/00 , A61L2/025 , A61L101/02 , A61L101/06 , A61L101/20 , A61L101/22 , A61L101/32 , A61L101/34 , A61L101/36 , A61L101/38 , A61L101/40 , A61L101/54
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译： 本发明包括一种新的方法，用于在植入有需要的接受者之前安全，有效和高效地将组织汇集起来进行治疗。 在一个实施方案中，所述方法包括灌注多孔植入物，其实现所需因子与植入物的孔隙中的不期望因子的有效渗透和去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活 ，病毒等以及其抗原性降低）以及通过这种治疗产生的新型植入物。 该方法提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致用于植入的高度清洁的组织和其他植入物。 该过程的目标净化目标包括细菌污染减少约1（1）至12（12）个，包膜病毒污染减少约1（1）至15（15）个对数，最多约5 ）减少无包膜病毒污染，减少内毒素约两（2）至十（10）倍，维持植入或移植物生物和生物力学特性，不存在由于使用的清洁溶液导致的组织毒性，以及减少的植入物 抗原性。
-
公开(公告)号：EP1128849B1
公开(公告)日：2007-02-07
申请号：EP99967099.5
申请日：1999-11-08
发明人： MILLS, C., Randal , WIRONEN, John, F. , HANSTKE, Sean , DONDA, Russel, S. , GROOMS, Jamie, M. , BIANCHI, John, R.
IPC分类号： A61L2/00 , A61L2/025 , A61L101/02 , A61L101/06 , A61L101/20 , A61L101/22 , A61L101/32 , A61L101/34 , A61L101/36 , A61L101/38 , A61L101/40 , A61L101/54
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
-
公开(公告)号：EP1244477A2
公开(公告)日：2002-10-02
申请号：EP00989587.1
申请日：2000-12-29
IPC分类号： A61L24/00
CPC分类号： A61J1/2096 , A61F2/4601 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61F2002/4685 , A61J1/201 , A61J1/2058 , A61J1/2062 , A61J1/2089 , A61L24/0005 , A61L24/0094 , A61L27/3604 , A61L27/48 , B01F5/0685 , B01F11/0082 , B01F13/002 , B01F13/0023 , B01F15/00506 , B01F15/0201 , B01F15/0225 , B01F2215/0029
摘要： Disclosed herein is an efficient and cost-effective system for reconstituting bone pastes comprising a first syringe containing a reconstitution fluid and second syringe containing paste components, wherein said first and second syringes are communicatingly interconnectable. Also disclosed are novel methods for producing and storing bone pastes.
摘要翻译： 本文公开了用于重构骨浆的有效且成本有效的系统，其包括含有重构流体的第一注射器和含有糊剂组分的第二注射器，其中所述第一注射器和第二注射器可连通地互连。 还公开了用于生产和储存骨浆的新型方法。
-
公开(公告)号：EP1202756A1
公开(公告)日：2002-05-08
申请号：EP00952270.7
申请日：2000-07-28
发明人： WIRONEN, John F. , GROOMS, Jamie
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30756 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30235 , A61F2002/30772 , A61F2002/30774 , A61F2002/30813 , A61F2002/30841 , A61F2002/30866 , A61F2002/30892 , A61F2002/448 , A61F2230/0069 , A61L2/0088 , A61L27/3608 , A61L27/3645
摘要： The present invention relates to reduced antigenicity tissue (RAT) implants, including bone implant materials comprising reduced antigenicity bone (RAB) and cartilage implant materials comprising reduced antigenicity cartilage (RAC) by virtue of having been treated to remove substantially all non-collagenous proteins from the bone or cartilage implant matrix. In specific applications of the invention the RAB and RAC implants are treated with osteogenic (osteoinductive or osteoconductive) or cartilage growth inducing compositions, including but not limited to bone morphogenic proteins, cartilage derived morphogenic proteins, growth factors, peptides, cells, natural or recombinant, expressing such proteins or growth factors, and expressible nucleic acids encoding such proteins, peptides, growth factors, or combinations thereof.
-
公开(公告)号：EP1202755A1
公开(公告)日：2002-05-08
申请号：EP00952271.5
申请日：2000-07-28
CPC分类号： A61L27/3683 , A61F2/28 , A61F2/30756 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30224 , A61F2002/30235 , A61F2002/30772 , A61F2002/30774 , A61F2002/30813 , A61F2002/30841 , A61F2002/30866 , A61F2002/30892 , A61F2002/448 , A61F2230/0069 , A61K48/00 , A61L27/227 , A61L27/3608 , A61L27/3612 , A61L27/3645 , A61L27/54 , A61L2300/258 , A61L2300/412 , A61L2430/40
摘要： The present invention relates to tissues, including but not limited to bone and cartilage implants, as carrier matrices for delivery of biologically active nucleic acids to sites where such tissues are to be implanted. Upon implantation, the nucleic acids associated with the implants are taken up by cells within the implant site and are expressed, to produce growth factors, regenerative factors and the like encoded by the nucleic acids. In this manner, for example, where the nucleic acid encodes bone morphogenetic protein or the like, the rate of bone induction, conduction of healing and the rate of cartilage formation or repair is enhanced, without the attendant need to manufacture, purify, isolate and deliver protein or peptide growth factors.
摘要翻译： 本发明涉及组织，包括但不限于骨和软骨植入物，作为载体基质，用于将生物活性核酸递送至要植入组织的部位。 植入后，与植入物相关的核酸被植入部位内的细胞摄取并被表达，以产生由核酸编码的生长因子，再生因子等。 以这种方式，例如，在核酸编码骨形态发生蛋白等的情况下，增强了骨诱导率，愈合传导率和软骨形成或修复的速率，而无需伴随制造，纯化，分离和 递送蛋白质或肽生长因子。
-
公开(公告)号：EP1427322A2
公开(公告)日：2004-06-16
申请号：EP02757406.0
申请日：2002-08-27
IPC分类号： A61B1/00
CPC分类号： A61B17/1637 , A61B17/1671 , A61B17/8645 , A61F2/08 , A61F2/0811 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30131 , A61F2002/30133 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30962 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0013 , A61F2230/0015 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0082 , A61L24/0005 , A61L27/3604 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/365 , A61L27/3658 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L31/005 , A61L2430/02 , A61L2430/34 , A61L2430/40
摘要： Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.
-
公开(公告)号：EP1359951A2
公开(公告)日：2003-11-12
申请号：EP02720893.3
申请日：2002-01-25
发明人： WIRONEN, John, F.
CPC分类号： A61L27/56 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/30011 , A61F2002/30062 , A61F2002/30968 , A61F2210/0004 , A61F2250/0023 , A61F2310/00293 , A61F2310/00329 , A61L27/10 , A61L27/12 , A61L27/50 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2400/06 , A61L2430/02
摘要： A bone-like implant capable of increasing its porosity in situ comprising at least one bone-like compound with at least one hydrophobic carrier, or a degradable component. The bone-like implant includes its manufacture and methods of use. One aspect of the bone-like implant is to provide a method of repairing a bone defect or related injuries. The bone-like implant includes several embodiements capable of increasing its porosity in situ.
-
公开(公告)号：EP1333870A2
公开(公告)日：2003-08-13
申请号：EP01973325.2
申请日：2001-09-20
CPC分类号： A61L27/3839 , A61L2/0082 , A61L27/3604 , A61L27/362 , A61L27/3687 , A61L27/3691 , A61L2430/40
摘要： Disclosed is a method for processing collagen-based tissues or organ to substantially decellularize said collagen-based tissues or organs prior to implantation into a recipient in need thereof. Preferably, the method significantly reduces or eliminates immunogenicity of the tissue or organ such that upon transplantation, the tissue or organ is not rejected by the recipient's immune system. The method includes removing the tissue from a donor, processing the tissue to remove substantially all of the cells of the tissue or organ, and processing of the collagen scaffold for storage. The method further includes repopulating the collagen scaffold through seeding with stem cells for implantation into recipient.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.016 秒)
