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    PROPHYLACTIC/THERAPEUTIC AGENT FOR INFLUENZA VIRUS INFECTION
    1.
    发明公开
    PROPHYLACTIC/THERAPEUTIC AGENT FOR INFLUENZA VIRUS INFECTION 有权
    PROPHYLAKTISCHER ODER THERAPEUTISCHER WIRKSTOFF GEGEN GRIPPEVIRUSINFEKTION

    公开(公告)号：EP2875813A1

    公开(公告)日：2015-05-27

    申请号：EP13819512.8

    申请日：2013-06-03

    申请人： SBI Pharmaceuticals Co., Ltd. ,  The University of Tokushima

    发明人： TANAKA, Tohru ,  NAKAJIMA, Motowo ,  TAKAHASHI, Kiwamu ,  ISHII, Takuya ,  KIDO, Hiroshi ,  CHIDA, Junji ,  YAMANE, Kazuhiko

    IPC分类号： A61K31/197 ,  A61K33/26 ,  A61P3/00 ,  A61P31/16 ,  A61P43/00

    CPC分类号： A61K31/197 ,  A61K31/194 ,  A61K33/26 ,  A61K45/06 ,  A61K2300/00

    摘要： Provided is a prophylactic/therapeutic agent for influenza viral infection that is effective not only before and at an early stage of infection with influenza virus but also at an intermediate or late stage of the infection and is highly safe for human bodies. A prophylactic/therapeutic drug for influenza viral infection comprising, as active ingredients, 5-aminolevulinic acid (5-ALA), a derivative thereof or a salt of the 5-ALA or the derivative, and an iron compound is prepared. This prophylactic/therapeutic agent can be used for ameliorating (preventing) depression in food consumption, water consumption and body weight, for ameliorating (decreasing) increase in ketone body levels in blood that may otherwise cause ketosis, for ameliorating (preventing) depression in ATP levels in blood, or for ameliorating (increasing) a survival rate and depression in a body surface temperature.

    摘要翻译： 提供了一种流感病毒感染的预防/治疗剂，其不仅在感染流感病毒之前和早期阶段都有效，而且在感染的中期或晚期也是有效的，并且对人体是高度安全的。 制备用于流感病毒感染的预防/治疗药物，其包含作为活性成分的5-氨基乙酰丙酸（5-ALA），其衍生物或5-ALA或其衍生物的盐和铁化合物。 该预防/治疗剂可用于改善（预防）食物消耗，饮水和体重中的抑制，以改善（减少）可能引起酮症的血液中酮体水平的升高（降低），以改善（预防）ATP抑制 血液中的水平，或改善（增加）体表温度的存活率和抑郁症。

    CANCER HEAT THERAPY-ENHANCING AGENT
    4.
    发明公开
    CANCER HEAT THERAPY-ENHANCING AGENT 有权
    MITTEL ZURVERSTÄRKUNGEINERKREBSWÄRMETHERAPIE

    公开(公告)号：EP2617416A1

    公开(公告)日：2013-07-24

    申请号：EP11824763.4

    申请日：2011-09-12

    申请人： Tokyo University of Agriculture Educational Corporation ,  SBI Pharmaceuticals Co., Ltd.

    发明人： CHIBAZAKURA, Taku ,  TANAKA, Tohru ,  TAKAHASHI, Kiwamu ,  NAKAJIMA, Motowo ,  ABE, Fuminori

    IPC分类号： A61K31/197 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07C229/22 ,  A61K31/197

    摘要： Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1):

            R 2 R 1 NCH 2 COCH 2 CH 2 COR 3      (1)

    [wherein R 1 and R 2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R 3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

    摘要翻译： 提供了不与光动力疗法结合的癌症热疗的增强剂。 通过使用作为癌症热疗的增强剂，通过式（1）表示的5-氨基乙酰丙酸可以获得不与光动力疗法组合的癌症治疗：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR2 R 1 NCH 2 COCH 2 CH 2 COR 3€ƒ€ƒ€ƒ（1）[其中R 1和R 2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基 ，或芳烷基; R 3表示羟基，烷氧基，酰氧基，烷氧基羰氧基，芳氧基，芳烷氧基或氨基]或其盐。

    METHOD FOR ELIMINATING STEM CELLS, METHOD FOR PROTECTING DIFFERENTIATED CELLS, AND CULTURE MEDIUM COMPOSITION
    7.
    发明公开
    METHOD FOR ELIMINATING STEM CELLS, METHOD FOR PROTECTING DIFFERENTIATED CELLS, AND CULTURE MEDIUM COMPOSITION 审中-公开
    消除干细胞的方法，保护分化细胞的方法以及培养基培养基组合物

    公开(公告)号：EP3282011A1

    公开(公告)日：2018-02-14

    申请号：EP16776540.3

    申请日：2016-04-06

    申请人： Reprocell Incorporated ,  SBI Pharmaceuticals Co., Ltd.

    发明人： YOSHIDA, Shunsuke ,  INAMURA, Mitsuru ,  TANAKA, Tohru ,  ISHIKAWA, Hiroyuki ,  ITO, Hidenori

    IPC分类号： C12N5/10 ,  C12N1/00 ,  C12N1/02 ,  C12N5/0735

    CPC分类号： C12N5/16 ,  C07C233/56 ,  C12N1/00 ,  C12N1/02 ,  C12N5/10 ,  C12N2500/32 ,  C12N2529/10

    摘要： A stem cell removing method that certainly-removes an undifferentiated stem cell is provided. For this object, a cell group including a stem cell and a somatic cell performed differentiation induction is cultivated in culture medium composition including photosensitizer. Light of a specific wavelength is irradiated with the cell group, and the stem cell is removed, selectively. The stem cell is a pluripotent stem cell or a somatic stem cell. The pluripotent stem cell includes either an ES cell (Embryonic Stem Cell) or an iPS cell (induced Pluripotent Stem Cell). Also, somatic stem cell includes any one of a germ stem cell, a productive cell, a pluripotent stem cell and a stem cell having unipotency.

    摘要翻译： 提供确实除去未分化干细胞的干细胞除去方法。 为了该目的，在包含光敏剂的培养基组合物中培养包含干细胞和体细胞的细胞组进行分化诱导。 用细胞组照射特定波长的光，并选择性地去除干细胞。 干细胞是多能干细胞或成体干细胞。 多能干细胞包括ES细胞（胚胎干细胞）或iPS细胞（诱导多能干细胞）。 此外，体干细胞包括生殖干细胞，生产细胞，多能干细胞和具有单能性的干细胞中的任一种。

    PHOTODYNAMIC DIAGNOSIS APPARATUS PROVIDED WITH COLLIMATOR
    10.
    发明公开
    PHOTODYNAMIC DIAGNOSIS APPARATUS PROVIDED WITH COLLIMATOR 审中-公开
    荧光显微镜诊断仪

    公开(公告)号：EP2888988A1

    公开(公告)日：2015-07-01

    申请号：EP13831452.1

    申请日：2013-08-21

    申请人： SBI Pharmaceuticals Co., Ltd.

    发明人： INOUE, Katsushi ,  HIRAMITSU, Masanori ,  NAKAJIMA, Motowo ,  TANAKA, Tohru

    IPC分类号： A61B1/00 ,  A61B10/00 ,  G01N21/64

    CPC分类号： A61B5/0071 ,  A61B1/00096 ,  A61B1/00167 ,  A61B1/043 ,  A61B1/0607 ,  A61B1/063 ,  A61B1/07 ,  A61B5/0084 ,  A61B5/7282 ,  A61B5/7405 ,  A61B2562/0238 ,  G01N21/645 ,  G01N2021/6484 ,  G02B21/0012 ,  G02B23/2469 ,  G02B23/26

    摘要： An object of the present invention is to provide a PDD diagnosis apparatus that even if there is a distance from an irradiation portion of an optical fiber to a diseased tissue, enables provision of a fluorescence detection sensitivity equivalent to that in a case where irradiation is provided in such a manner that the irradiation portion of the optical fiber is brought close to the diseased tissue. A diagnosis apparatus including: a light source unit that emits excitation light to a photosensitizing substance accumulated in a diseased tissue; a detection unit that detects fluorescence produced from the photosensitizing substance; and an excitation light irradiation/fluorescence detection optical fiber including an output/input end with a collimator connected thereto, in which the excitation light emitted from the light source unit is guided to the excitation light irradiation/fluorescence detection optical fiber, and the excitation light output from the output/input end is provided in such a manner that the excitation light is collimated by the collimator and excites the photosensitizing substance accumulated in the diseased tissue; and the fluorescence produced by the photosensitizing substance excited by the excitation light is input from the output/input end via the collimator, and the input fluorescence is guided to the excitation light irradiation/fluorescence detection optical fiber and the fluorescence produced from the photosensitizing substance is detected in the detection unit is used.

    摘要翻译： 本发明的目的是提供一种PDD诊断装置，即使距离光纤的照射部分到患病组织有距离，能够提供与提供照射的情况相同的荧光检测灵敏度 使得光纤的照射部分靠近病变组织。 一种诊断装置，包括：光源单元，其向累积在患病组织中的光敏物质发射激发光; 检测单元，其检测由所述光敏物质产生的荧光; 以及激励光照射/荧光检测光纤，其包括具有连接到其上的准直器的输出端，其中从光源单元发射的激发光被引导到激发光照射/荧光检测光纤，并且激发光 以使得激发光被准直仪准直并激发累积在病变组织中的光敏物质的方式提供从输出/输入端输出; 并且通过准直器从输出输入端输入由激发光激发的光敏物质产生的荧光，并将输入荧光引导至激发光照射/荧光检测光纤，由光敏物质产生的荧光为 使用在检测单元中检测到的。