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1.发明授权Substituierte 8-Aminoalkoxixanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel 有权取代的8- Aminoalkoxixanthine，它们的制备方法和它们作为药物的用途
公开(公告)号：EP1778690B1
公开(公告)日：2012-08-22
申请号：EP05770568.3
申请日：2005-07-30
发明人： SCHOENAFINGER, Karl , JAEHNE, Gerhard , DEFOSSA, Elisabeth , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D473/08 , A61K31/522 , A61P3/10
CPC分类号： C07D473/04
摘要： The invention relates to substituted 8-aminoalkoxi-xanthines and to the physiologically compatible salts thereof and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the radicals have the above-mentioned meaning, in addition to the physiologically compatible salts thereof. The compounds are suitable, for example, as medicaments for the prevention and treatment of type 2 diabetes.
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公开(公告)号：EP1863488B1
公开(公告)日：2010-02-24
申请号：EP06723256.1
申请日：2006-03-07
申请人： Sanofi-Aventis
发明人： DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： A61K31/454 , A61P3/10 , C07D401/04
CPC分类号： C07D401/04 , A61K31/454
摘要： The invention relates to the use of amino-substituted benzimidazoles, in addition to their physiologically compatible salts, for producing medicaments that reduce blood-sugar levels. Said compounds are particularly suitable for the production of medicaments that treat diabetes. The invention relates to the use of compounds of formula (I), in which the groups are defined as cited in the description, in addition to the physiologically compatible salts of said compounds for producing a medicament that reduces the blood-sugar level.
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3.发明授权AMID SUBSTITUIERTE 8-N-BENZIMIDAZOLE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权AMID取代的8--N-苯并咪唑，生产和使用方法如药物
公开(公告)号：EP1863790B1
公开(公告)日：2010-02-10
申请号：EP06723257.9
申请日：2006-03-07
申请人： Sanofi-Aventis
发明人： DEFOSSA, Elizabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D401/04 , A61K31/435 , A61P3/10
CPC分类号： C07D401/04 , C07D401/14
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4.发明公开SUBSTITUIERTE 2-AMIN0ALKYLTHI0-BENZIMIDAZ0LE UND IHRE VERWENDUNG ZUR BLUTZUCKERSENKUNG 有权取代的2-氨基烷，苯并咪唑和它们用于降低血糖
公开(公告)号：EP1874737A1
公开(公告)日：2008-01-09
申请号：EP06723959.0
申请日：2006-04-01
申请人： sanofi-aventis
发明人： DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D235/28 , A61K31/4184 , A61P3/10
CPC分类号： C07D235/28
摘要： The invention relates to substituted 2-aminoalkylthio-benzimidazoles, in addition to the physiologically compatible salts thereof and physiologically functional derivatives thereof. The invention also relates to compounds of formula (I), wherein the radicals have the above-mentioned meaning, and the physiologically compatible salts thereof. Said compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
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5.发明公开SUBSTITUIERTE, BISZYKLISCHE 8-PYRROLIDINO-XANTHINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 审中-公开取代，BISZYKLISCHE 8吡咯烷子黄嘌呤，其制造方法相同，它们作为药物
公开(公告)号：EP1776372A1
公开(公告)日：2007-04-25
申请号：EP05774377.5
申请日：2005-07-22
发明人： SCHOENAFINGER, Karl , JAEHNE, Gerhard , DEFOSSA, Elisabeth , SCHWINK, Lothar , WAGNER, Holger , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D519/00 , A61K31/522
CPC分类号： C07D519/00
摘要： The invention relates to substituted, bicyclic 8-aminoxanthines, their physiologically compatible salts and to their physiologically functional derivatives. The invention relates to compounds of formula (I), in which the radicals have the cited meanings, and to their physiologically compatible salts. The compounds are suited, e.g. for use as medicaments for preventing and treating type 2 diabetes.
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6.发明公开NEUE CYANOTHIAZOLIDE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权新CYANOTHIAZOLIDE，其制造方法相同，它们作为药物
公开(公告)号：EP1651653A1
公开(公告)日：2006-05-03
申请号：EP04740985.9
申请日：2004-07-14
发明人： WAGNER, Holger , SCHOENAFINGER, Karl , JAEHNE, Gerhard , GAUL, Holger , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D513/04 , A61K31/415
CPC分类号： C07D487/04
摘要： The invention relates to compounds of formula (I), wherein the radicals have the meanings indicated in the text, the stereoisomeric forms thereof, the physiologically acceptable salts thereof, and methods for the production thereof. The inventive compounds are suitable for the treatment of metabolic diseases such as type 2 diabetes.
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7.发明授权NEUE INSULINDERIVATE MIT EXTREM VERZÖGERTEM ZEIT- / WIRKUNGSPROFIL 有权NEUE INSULINDERIVATE MIT EXTREMVERZÖGERTEMZEIT- / WIRKUNGSPROFIL
公开(公告)号：EP2229407B1
公开(公告)日：2016-11-16
申请号：EP09701358.5
申请日：2009-01-06
发明人： HABERMANN, Paul , SEIPKE, Gerhard , KURRLE, Roland , MÜLLER, Günter , SOMMERFELD, Mark , TENNAGELS, Norbert , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07K14/62
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公开(公告)号：EP1468092B1
公开(公告)日：2012-01-11
申请号：EP03701530.2
申请日：2003-01-20
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3, activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
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9.发明授权SUBSTITUIERTE 2-AMINOALKYLTHIO-BENZIMIDAZOLE UND IHRE VERWENDUNG ZUR BLUTZUCKERSENKUNG 有权取代的2-氨基烷，苯并咪唑和它们用于降低血糖
公开(公告)号：EP1874737B1
公开(公告)日：2010-08-04
申请号：EP06723959.0
申请日：2006-04-01
申请人： sanofi-aventis
发明人： DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D235/28 , A61K31/4184 , A61P3/10
CPC分类号： C07D235/28
摘要： The invention relates to substituted 2-aminoalkylthio-benzimidazoles, in addition to the physiologically compatible salts thereof and physiologically functional derivatives thereof. The invention also relates to compounds of formula (I), wherein the radicals have the above-mentioned meaning, and the physiologically compatible salts thereof. Said compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
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10.发明授权SUBSTITUIERTE, BIZYKLISCHE 8-PYRROLIDINO-BENZIMIDAZOLE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 有权取代的双环8吡咯苯并咪唑类，制造方法相同，它们作为药物
公开(公告)号：EP1863817B1
公开(公告)日：2008-05-28
申请号：EP06723254.6
申请日：2006-03-07
申请人： sanofi-aventis
发明人： DEFOSSA, Elisabeth , SCHOENAFINGER, Karl , JAEHNE, Gerhard , BUNNING, Christian , TSCHANK, Georg , WERNER, Ulrich
IPC分类号： C07D487/04 , A61P3/00 , A61P9/00 , A61K31/4184
CPC分类号： C07D487/04
摘要： The invention relates to substituted, bicyclic 8-pyrrolidino-benzimidazoles, in addition to the physiologically compatible salts and physiologically functional derivatives of said compounds. The invention relates to compounds of formula (I), in which the groups are defined as cited in the description and to the physiologically compatible salts of said compounds. The compounds are suitable for use, for example, as medicaments for the prevention and treatment of type 2 diabetes.
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