公开(公告)号：EP2958897B1

公开(公告)日：2019-01-09

申请号：EP14754162.7

申请日：2014-02-19

申请人： Senomyx, Inc.

发明人： CHUMAKOVA, Lyudmyla ,  PATRON, Andrew ,  PRIEST, Chad ,  KARANEWSKY, Donald, S. ,  KIMMICH, Rachel ,  BOREN, Brant, C. ,  HAMMAKER, Jeffrey, R. ,  CHUMAKOV, Volodymyr ,  ZHAO, Wen ,  NONCOVICH, Alain ,  UNG, Jane

IPC分类号： C07D231/20 ,  C07D403/06 ,  A61K31/4152 ,  A61P43/00 ,  A23L2/52 ,  C07D333/22 ,  C07D233/78 ,  C07D401/06 ,  C07D239/22 ,  C07D405/06 ,  C07D409/06 ,  C07D239/62 ,  C07D207/26 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D235/02 ,  C07C233/31

公开(公告)号：EP2958897A2

公开(公告)日：2015-12-30

申请号：EP14754162.7

申请日：2014-02-19

申请人： Senomyx, Inc.

发明人： CHUMAKOVA, Lyudmyla ,  PATRON, Andrew ,  PRIEST, Chad ,  KARANEWSKY, Donald, S. ,  KIMMICH, Rachel ,  BOREN, Brant, C. ,  HAMMAKER, Jeffrey, R. ,  CHUMAKOV, Volodymyr ,  ZHAO, Wen ,  NONCOVICH, Alain ,  UNG, Jane

IPC分类号： C07D231/20 ,  C07D403/06 ,  A61K31/4152 ,  A61P43/00

CPC分类号： C07D231/20 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  C07C233/31 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/26 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D233/78 ,  C07D235/02 ,  C07D239/22 ,  C07D239/62 ,  C07D333/22 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06

摘要： The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

公开(公告)号：EP3461816A1

公开(公告)日：2019-04-03

申请号：EP18205180.5

申请日：2014-02-19

申请人： Senomyx, Inc.

发明人： CHUMAKOVA, Lyudmyla ,  PATRON, Andrew ,  PRIEST, Chad ,  KARANEWSKY, Donald S. ,  KIMMICH, Rachel ,  BOREN, Brant C. ,  HAMMAKER, Jeffrey R. ,  CHUMAKOV, Volodymyr ,  ZHAO, Wen ,  NONCOVICH, Alain ,  UNG, Jane

IPC分类号： C07D231/20 ,  C07D403/06 ,  A61K31/4152 ,  A61P43/00 ,  A23L2/52 ,  C07D333/22 ,  C07D233/78 ,  C07D401/06 ,  C07D239/22 ,  C07D405/06 ,  C07D409/06 ,  C07D239/62 ,  C07D207/26 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D235/02 ,  C07C233/31

摘要： The present invention includes compounds useful as modulators of TRPM8, such as compunds of Formulae (1a), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compunds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.