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公开(公告)号：EP2958897B1
公开(公告)日：2019-01-09
申请号：EP14754162.7
申请日：2014-02-19
申请人： Senomyx, Inc.
发明人： CHUMAKOVA, Lyudmyla , PATRON, Andrew , PRIEST, Chad , KARANEWSKY, Donald, S. , KIMMICH, Rachel , BOREN, Brant, C. , HAMMAKER, Jeffrey, R. , CHUMAKOV, Volodymyr , ZHAO, Wen , NONCOVICH, Alain , UNG, Jane
IPC分类号： C07D231/20 , C07D403/06 , A61K31/4152 , A61P43/00 , A23L2/52 , C07D333/22 , C07D233/78 , C07D401/06 , C07D239/22 , C07D405/06 , C07D409/06 , C07D239/62 , C07D207/26 , C07D207/32 , C07D207/333 , C07D213/50 , C07D235/02 , C07C233/31
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公开(公告)号：EP2635572B1
公开(公告)日：2018-10-17
申请号：EP11838869.3
申请日：2011-11-04
申请人： Senomyx, Inc.
发明人： PRIEST, Chad , NONCOVICH, Alain , PATRON, Andrew , UNG, Jane
IPC分类号： C07D409/12 , C07D413/12 , C07D409/14 , A61K31/4155 , A61K31/422 , A61K8/49 , A61P17/00
CPC分类号： A61K31/497 , A01N37/18 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/60 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A23L27/88 , A23L33/10 , A23V2002/00 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4973 , A61K8/4986 , A61K8/69 , A61K31/165 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4409 , A61K31/4436 , A61K2800/10 , A61K2800/40 , A61Q1/02 , A61Q5/02 , A61Q5/12 , A61Q9/02 , A61Q11/00 , A61Q15/00 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/10 , C07C233/11 , C07C235/20 , C07C235/24 , C07C235/34 , C07C2601/14 , C07D213/40 , C07D213/75 , C07D231/40 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/32 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
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公开(公告)号：EP3356356A1
公开(公告)日：2018-08-08
申请号：EP16852328.0
申请日：2016-09-21
申请人： Senomyx, Inc.
发明人： PATRON, Andrew, P. , NONCOVICH, Alain , UNG, Jane , DAVIS, Timothy , FOTSING, Joseph, R. , PRIEST, Chad , TACHDJIAN, Catherine
IPC分类号： C07D409/12 , A61K31/4155 , A61K8/49 , A23L33/10 , A61Q19/00
CPC分类号： C07D409/12 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K31/4155 , B65D65/38 , B65D81/18
摘要： The present disclosure relates to compounds which are useful as cooling sensation compounds.
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公开(公告)号：EP2195656A2
公开(公告)日：2010-06-16
申请号：EP08795436.8
申请日：2008-08-19
申请人： Senomyx, Inc.
发明人： LI, Xiaodong , PATRON, Andrew , TACHDJIAN, Catherine , XU, Hong , LI, Qing , PRONIN, Alexey , SERVANT, Guy , ZHANG, Lan , BRADY, Thomas , DARMOHUSODO, Vincent , ARELLANO, Melissa , SELCHAU, Victor , CHING, Brett Weylan , KARANEWSKY, Donald S. , BRUST, Paul , LING, Jing , ZHAO, Wen , PRIEST, Chad
IPC分类号： G01N33/53
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
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公开(公告)号：EP2958897A2
公开(公告)日：2015-12-30
申请号：EP14754162.7
申请日：2014-02-19
申请人： Senomyx, Inc.
发明人： CHUMAKOVA, Lyudmyla , PATRON, Andrew , PRIEST, Chad , KARANEWSKY, Donald, S. , KIMMICH, Rachel , BOREN, Brant, C. , HAMMAKER, Jeffrey, R. , CHUMAKOV, Volodymyr , ZHAO, Wen , NONCOVICH, Alain , UNG, Jane
IPC分类号： C07D231/20 , C07D403/06 , A61K31/4152 , A61P43/00
CPC分类号： C07D231/20 , A23L2/52 , A23L33/10 , A23V2002/00 , C07C233/31 , C07C2601/04 , C07C2601/14 , C07C2601/16 , C07D207/26 , C07D207/32 , C07D207/333 , C07D213/50 , C07D233/78 , C07D235/02 , C07D239/22 , C07D239/62 , C07D333/22 , C07D401/06 , C07D403/06 , C07D405/06 , C07D409/06
摘要： The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
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6.发明公开BIS-AROMATIC AMIDES AND THEIR USES AS SWEET FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS 审中-公开双芳香酰胺和它们作为甜味味觉增强物质改性剂，风味物质和
公开(公告)号：EP1907353A2
公开(公告)日：2008-04-09
申请号：EP06784965.3
申请日：2006-06-15
申请人： Senomyx Inc.
发明人： TACHDJIAN, Catherine , PATRON, Andrew P. , BAKIR, Farid , AVERBUJ, Claudia , PRIEST, Chad , ADAMSKI-WERNER, Sara L. , CHEN, Qing , DARMOHUSODO, Vincent , LEBL-RINNOVA, Marketa , KIMMICH, Rachel, D., A. , TANG, Xiao-Qing , SHIGEMURA, Rhondi
CPC分类号： A23L2/39 , A23G3/36 , A23G9/32 , A23L7/122 , A23L27/204 , A23L27/205 , A23L27/30 , A23V2002/00 , C07C233/11 , C07C233/22 , C07C235/34 , C07C235/78 , C07C237/20 , C07C255/57 , C07C271/22 , C07D213/30 , C07D213/85 , C07D239/26 , C07D241/24 , C07D307/52 , C07D307/54 , C07D333/24 , A23V2200/16
摘要： The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.
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7.发明公开MOLECULES COMPRISING LINKED ORGANIC MOIETIES AS FLAVOR MODIFIERS FOR COMESTIBLES COMPOSITIONS 审中-公开与分子交联的有机仍为剂的味道，营养成分
公开(公告)号：EP1855548A2
公开(公告)日：2007-11-21
申请号：EP06720268.9
申请日：2006-02-06
申请人： Senomyx, Inc.
发明人： TACHDJIAN, Catherine , PATRON, Andrew P. , LEBL-RINNOVA, Marketa , TANG, Xiao-qing , DARMOHUSODO, Vincent , PRIEST, Chad
IPC分类号： A23L1/226
CPC分类号： A23L27/2056 , A23L27/20 , A23L27/2022 , A23L27/203 , A23L27/204 , A23L27/2052 , A23L27/2054
摘要： The inventions disclosed herein relate to genuses of non-naturally occurring small molecule compounds which comprise two or optionally three organic moieties of limited size 'linked' by certain structurally related 'linker' functional groups. Suitable linker groups include ester, amine, ether, keto, imino, thioamide, thioether, sulfonamide, sulfonate ester, sulfone, guanidine, and thiourea groups. The compounds are capable, when contacted with comestible food or drinks or pharmaceutical compositions, at concentrations preferably on the order of about 100 ppm or lower, of serving as savory ('umami') or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for use in foods, beverages, and other comestible or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as monosodium glutamate or known natural or artificial sweeteners.
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8.发明公开AROMATIC AMIDES AND UREAS AND THEIR USES AS SWEET AND/OR UMAMI FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS 审中-公开芳香酰胺和尿素和用途新鲜和/或鲜的口味调节剂调味品和作为味道放大器
公开(公告)号：EP1848289A2
公开(公告)日：2007-10-31
申请号：EP06720357.0
申请日：2006-02-06
申请人： Senomyx, Inc.
发明人： TACHDJIAN, Catherine , PATRON, Andrew, P. , QI, Ming Cai Lun Lu , ADAMINSKI-WERNER, Sara , TANG, Xiao-Qing , QING, Chen , DARMOHUSODO, Vincent , LEBL-RINNOVA, Marketa , PRIEST, Chad
CPC分类号： A23L27/2056 , A23L27/205
摘要： The inventions disclosed herein relate to non-naturally occurring amide compounds that are capable, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, of serving as savory ('umami') or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for use in foods, beverages, and other comestible or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as monosodium glutamate or known natural and artificial sweeteners.
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公开(公告)号：EP3461816A1
公开(公告)日：2019-04-03
申请号：EP18205180.5
申请日：2014-02-19
申请人： Senomyx, Inc.
发明人： CHUMAKOVA, Lyudmyla , PATRON, Andrew , PRIEST, Chad , KARANEWSKY, Donald S. , KIMMICH, Rachel , BOREN, Brant C. , HAMMAKER, Jeffrey R. , CHUMAKOV, Volodymyr , ZHAO, Wen , NONCOVICH, Alain , UNG, Jane
IPC分类号： C07D231/20 , C07D403/06 , A61K31/4152 , A61P43/00 , A23L2/52 , C07D333/22 , C07D233/78 , C07D401/06 , C07D239/22 , C07D405/06 , C07D409/06 , C07D239/62 , C07D207/26 , C07D207/32 , C07D207/333 , C07D213/50 , C07D235/02 , C07C233/31
摘要： The present invention includes compounds useful as modulators of TRPM8, such as compunds of Formulae (1a), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compunds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
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公开(公告)号：EP2635572A2
公开(公告)日：2013-09-11
申请号：EP11838869.3
申请日：2011-11-04
申请人： Senomyx, Inc.
发明人： PRIEST, Chad , NONCOVICH, Alain , PATRON, Andrew , UNG, Jane
IPC分类号： C07D409/12 , C07D413/12 , C07D409/14 , A61K31/4155 , A61K31/422 , A61K8/49 , A61P17/00
CPC分类号： A61K31/497 , A01N37/18 , A01N43/10 , A01N43/40 , A01N43/56 , A01N43/60 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/90 , A23L27/88 , A23L33/10 , A23V2002/00 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4973 , A61K8/4986 , A61K8/69 , A61K31/165 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4409 , A61K31/4436 , A61K2800/10 , A61K2800/40 , A61Q1/02 , A61Q5/02 , A61Q5/12 , A61Q9/02 , A61Q11/00 , A61Q15/00 , A61Q17/02 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/10 , C07C233/11 , C07C235/20 , C07C235/24 , C07C235/34 , C07C2601/14 , C07D213/40 , C07D213/75 , C07D231/40 , C07D277/28 , C07D307/52 , C07D333/20 , C07D333/24 , C07D333/32 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
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