利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.039 秒)

    BICYCLIC NITROGENATED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
    1.
    发明公开
    BICYCLIC NITROGENATED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 审中-公开

    公开(公告)号：EP3527568A1

    公开(公告)日：2019-08-21

    申请号：EP17863024.0

    申请日：2017-10-16

    申请人： Shionogi & Co., Ltd

    发明人： MASUDA, Koji ,  SUGIYAMA, Shuichi ,  YAMADA, Toru ,  KOJIMA, Eiichi ,  OGAWA, Tomoyuki ,  KOBAYASHI, Naotake ,  KAI, Hiroyuki

    IPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5383 ,  A61P43/00 ,  C07D487/04 ,  C07D498/04

    摘要： Provided are a novel compound having an antagonistic activity for the P2X 7 receptor, and a pharmaceutical composition having an antagonistic activity for the P2X 7 receptor. A compound represented by Formula (I):

    wherein Z 1 is C(R 4 ) or the like; R 4 is a hydrogen atom or the like; Z 2 is C(R 5a )(R 5a' ) or the like; the dashed line represents the presence or absence of a bond; when the dashed line represents the presence of a bond, then R 5a' is absent; R 5a and R 5a' are each independently a hydrogen atom or the like; Ring Q is a substituted or unsubstituted 5-membered non-aromatic heterocycle or the like; Y 1 is O or the like; R 2a is a group represented by the formula: -(C(R 2a' )(R 2b' )) n -R 1 ; R 2b is a hydrogen atom or the like; R 2a' and R 2b' is each independently a hydrogen atom or the like; R 1 is substituted or unsubstituted aromatic carbocyclyl or the like; X is N(R 7a ) or the like; R 7a is a hydrogen atom or the like; R 3 is substituted or unsubstituted aromatic carbocyclyl or the like; n is an integer from 0 to 4; and m is an integer from 0 to 4, or a pharmaceutically acceptable salt thereof.

    SUSTAINED HIV PROTEASE INHIBITOR
    2.
    发明公开
    SUSTAINED HIV PROTEASE INHIBITOR 审中-公开
    持久的HIV蛋白酶抑制剂

    公开(公告)号：EP3192794A1

    公开(公告)日：2017-07-19

    申请号：EP15839901.4

    申请日：2015-09-10

    申请人： Shionogi & Co., Ltd.

    发明人： KAWASUJI, Takashi ,  MIKAMIYAMA, Hidenori ,  SUZUKI, Naoyuki ,  MASUDA, Koji ,  SUGIMOTO, Hideki ,  OKANO, Azusa ,  YOSHIDA, Miho ,  SUGIYAMA, Shuichi ,  ASAHI, Kentarou ,  KOZONO, Iori ,  MIYAZAKI, Keisuke ,  OZASA, Hiroki ,  MIYAGAWA, Masayoshi

    IPC分类号： C07D409/12 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4436 ,  A61K31/4525 ,  A61P31/18 ,  A61P43/00 ,  C07D493/04 ,  C12N9/99

    CPC分类号： C07D493/04 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4436 ,  A61K31/4525 ,  A61P31/18 ,  C07D231/56 ,  C07D333/72 ,  C07D409/12 ,  C07D519/00 ,  C12N9/99

    摘要： The present invention provides useful compounds for HIV protease inhibitor. A compound represented by formula or its pharmaceutically acceptable salt Formula:

    wherein ring A is

    R 4 is -Y-Z, hydrogen atom, halogen, hydroxy and the like,
    R 5 is hydrogen atom, halogen, hydroxy and the like,
    R 6 is each independently halogen, hydroxy, carboxy and the like,
    ring A may be substituted with said R 6 at any substitutable position(s),
    a is an integer of 0 to 7,
    ring B is substituted or unsubstituted aromatic carbocyclyl, or substituted or unsubstituted aromatic heterocyclyl,
    ring C is substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl,
    R 1 is -Y-Z, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl and the like,
    R 2 and R 3 are each independently -Y-Z or hydrogen atom,
    provided that at least one of R 1 , R 2 , R 3 and R 4 is a group represented by formula: -Y-Z,
    Y is a bond, or a spacer of any combination selected from the group consisting of -O-, -S-, -NR 7 -, -C(=O)-, -SO-, -SO 2 -, -NR 7 -C(=O)-, -C(=O)-NR 7 -, -NR 7 -C(=O)-NR 7 -, -NR 7 -C(=O)-O-, -SO 2 -NR 7 -, -NR 7 -SO 2 -, substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, substituted or unsubstituted alkynylene, substituted or unsubstituted aromatic carbocyclediyl, substituted or unsubstituted non-aromatic carbocyclediyl, substituted or unsubstituted aromatic heterocyclediyl and substituted or unsubstituted non-aromatic heterocyclediyl,
    R 7 are each independently hydrogen atom, hydroxy, carboxy and the like, and
    Z is substituted aromatic carbocyclyl, substituted non-aromatic carbocyclyl, substituted aromatic heterocyclyl or substituted non-aromatic heterocyclyl.

    摘要翻译： 本发明提供了用于HIV蛋白酶抑制剂的有用化合物。 由式或其药学上可接受的盐表示的化合物或其药学上可接受的盐式：其中环A为R 4为-YZ，氢原子，卤素，羟基等，R 5为氢原子，卤素，羟基等，R 6各自独立地为卤素，羟基 ，羧基等，环A可以在任何可取代的位置被所述R6取代，a是0-7的整数，环B是取代或未取代的芳族碳环基或取代或未取代的芳族杂环基，环C是 取代或未取代的芳族碳环基，取代或未取代的非芳族碳环基，取代或未取代的芳族杂环基或取代或未取代的非芳族杂环基，R1是-YZ，取代或未取代的烷基，取代或未取代的烯基， 例如，R2和R3各自独立地是-YZ或氢原子，条件是R1，R2，R3和R4中的至少一个是由式-YZ表示的基团， Y是键，或选自-O - ， - S - ， - NR 7 - ， - C（= O） - ， - SO - ， - SO 2 - ， - NR 7 -C （= O）-NR 7 - ， - NR 7 -C（= O）-NR 7 - ， - NR 7 -C（= O）-O - ， - SO 2 -NR 7 - ，取代或未取代的亚烷基，取代或未取代的亚烯基，取代或未取代的亚炔基，取代或未取代的芳族碳环基，取代或未取代的非芳族碳环基，取代或未取代的芳族杂环二基和取代或未取代的非芳族杂环二基， ，羟基，羧基等，Z是取代的芳族碳环基，取代的非芳族碳环基，取代的芳族杂环基或取代的非芳族杂环基。

    OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY
    3.
    发明公开
    OXADIAZOLE DERIVATIVE HAVING ENDOTHELIAL LIPASE INHIBITORY ACTIVITY 有权
    OXADIAZOLDERIVAT MIT ENDOTHELIALLIPASE-HEMMENDER WIRKUNG

    公开(公告)号：EP2514749A1

    公开(公告)日：2012-10-24

    申请号：EP10837586.6

    申请日：2010-12-14

    申请人： Shionogi & Co., Ltd.

    发明人： MASUDA, Koji ,  KIDA, Shiro ,  YOSHIKAWA, Naoki ,  KATOU, Manabu ,  KATO, Terukazu ,  NAKAJIMA, Mado ,  KOJIMA, Eiichi ,  YONEHARA, Mitsuhiro

    IPC分类号： C07D413/06 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P43/00 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

    CPC分类号： A61K31/423 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/433 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D413/06 ,  C07D417/06 ,  C07D417/14 ,  C07D513/04

    摘要： Disclosed is a compound which is useful as an endothelial lipase inhibitor.
    A compound represented by the formula:

    its pharmaceutically acceptable salt, or a solvate thereof,
    wherein
    Ring A is aromatic carbocycle or aromatic heterocycle,
    Z is -NR 5 -, -O- or -S-,
    R 5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl or the like,
    R 1 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,
    R 2 and R 3 are each independently hydrogen, halogen, hydroxy or the like,
    R 4 is a group represented by the formula: -(CR 6 R 7 )n-R 8 ,
    wherein R 6 and R 7 are each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, R 8 is carboxy, cyano, substituted or unsubstituted alkyl or the like,
    R x is halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like,
    m is an integer of 0 to 3.

    摘要翻译： 公开了可用作内皮脂肪酶抑制剂的化合物。 由下式表示的化合物：其药学上可接受的盐或其溶剂合物，其中环A是芳族碳环或芳族杂环，Z是-NR 5 - ， - O-或-S-，R 5是氢，取代或未取代的 烷基，取代或未取代的烯基，取代或未取代的炔基，取代或未取代的芳基等，R 1为氢，卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基，取代或未取代的链烯基等 和R 3各自独立地为氢，卤素，羟基等，R 4为下式所示的基团： - （CR 6 R 7）n R 8，其中R 6和R 7各自独立地为氢，卤素，羟基或 n为0〜3的整数，R 8为羧基，氰基，取代或未取代的烷基等，R x为卤素，羟基，氰基，硝基，羧基，取代或未取代的烷基，取代或未取代的链烯基或 m为0〜3的整数。

    ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11 BETA -HYDROXYSTEROID DEHYDROGENASE TYPE I
    6.
    发明公开
    ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11 BETA -HYDROXYSTEROID DEHYDROGENASE TYPE I 审中-公开
    ISOXAZOLDERIVAT UND ISOTHIAZOLDERIVAT MIT HEMMENDER WIRKUNG AUF DIE 11 BETA-HYDROXYSTEROIDDEHYDROGENASE VOM TYP I

    公开(公告)号：EP2006286A2

    公开(公告)日：2008-12-24

    申请号：EP07739976.4

    申请日：2007-03-28

    申请人： Shionogi Co., Ltd.

    发明人： OGAWA, Tomoyuki ,  CHOMEI, Nobuo ,  MASUDA, Koji ,  TANAKA, Satoru

    IPC分类号： C07D261/18 ,  A61K31/42 ,  A61K31/425 ,  A61K31/454 ,  A61P3/10 ,  A61P43/00 ,  C07D275/02 ,  C07D413/12

    CPC分类号： C07D261/18 ,  C07D275/02 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

    摘要： Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.
    A compound represented by the formula:

    a pharmaceutically acceptable salt or solvate thereof,
    wherein
    R 1 is a group of the formula: -C(=O)NR 4 R 5 ,
    (wherein R 4 and R 5 are each independently, hydrogen, optionally substituted alkyl or the like) or
    a group of the formula: -NR 6 C(=O)R 7 ,
    (wherein R 6 and R 7 are each independently, hydrogen, optionally substituted alkyl or the like),
    X and Y are each independently -0- or the like,
    Z is a bond or the like,
    R 2 is optionally substituted alkyl, optionally substituted alkenyl or the like,
    R 3 is optionally substituted alkyl, optionally substituted alkenyl or the like.

    摘要翻译： 公开了用作11β-羟基类固醇脱氢酶1型抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂化物，其中R 1是下式的基团-C（= O）NR 4 R 5，（其中R 4和R 5各自独立地为氢，任选取代的烷基等）或下式-NR 6 C（= O）R 7基团（其中R 6和R 7各自独立地为 ，氢，任选取代的烷基等），X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的 取代的烷基，任选取代的烯基等。