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公开(公告)号：EP1688138A4
公开(公告)日：2008-01-16
申请号：EP04799921
申请日：2004-11-26
发明人： FUKATSU KOHJI , FUJII RYO , KOBAYASHI MAKOTO , YONEMORI JINICHI , TANAKA TOSHIO
IPC分类号： A61K31/192 , A61K31/216 , A61K31/341 , A61K31/4453 , A61K31/5375 , A61P3/04 , A61P3/06 , A61P3/08 , A61P43/00 , C07C45/68 , C07C45/71 , C07C59/68 , C07C69/734 , C07D213/64 , C07D213/643 , C07D277/34 , C07D295/08 , C07D295/092 , C07D295/096 , C07D307/12 , C07D307/16 , C07D317/54 , C07D333/32 , C07F7/18 , G01N33/15 , G01N33/50
CPC分类号： C07D213/643 , A61K31/192 , A61K31/216 , A61K31/341 , A61K31/4453 , A61K31/5375 , C07C45/68 , C07C45/71 , C07C59/68 , C07C69/734 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/64 , C07D277/34 , C07D295/088 , C07D295/096 , C07D307/12 , C07D317/54 , C07D333/32 , C07F7/1852 , C07C49/697 , C07C49/67 , C07C49/84 , C07C49/755 , C07C47/575
摘要： A 14273 receptor function regulating agent useful as a preventive/therapeutic agent for diabetes, hyperlipemia, etc. There is provided a 14273 receptor function regulating agent comprising a compound having a group capable of releasing an aromatic ring and a cation.
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公开(公告)号：EP1535915A4
公开(公告)日：2005-10-05
申请号：EP03794233
申请日：2003-09-04
IPC分类号： A61P1/14 , A61P1/18 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/00 , A61P17/00 , A61P19/02 , A61P25/02 , A61P25/28 , A61P27/02 , A61P35/00 , A61P37/00 , A61P43/00 , C07D307/38 , C07D307/42 , C07D307/54 , C07D307/68 , C07D307/79 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07F7/08 , C07D307/00 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/4155 , A61K31/422 , A61P3/00 , A61P9/00 , A61P13/00 , A61P19/00
CPC分类号： C07D307/42 , C07D307/38 , C07D307/54 , C07D307/68 , C07D307/79 , C07D405/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12
摘要： A compound represented by the formula (I) [wherein R represents an optionally substituted hydrocarbon group or optionally substituted heterocyclic group; p is 0, 1, or 2, provided that when p is 2, then the R's may be the same or different; R1 represents hydrogen or an optionally substituted hydrocarbon group; R2 represents an optionally substituted aromatic group; ring A represents an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring; X1 represents oxygen or sulfur; X2 represents a bond, oxygen, or -S(O)n- (n is 0, 1, or 2); Y represents a bond, oxygen, -S(O)m-, -C(=O)-N(R3)-, or -N(R3)-C(=O)- (R3 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group and m is 0, 1, or 2); M1, M2, and M3 may be the same or different and each independently represents a bond or an optionally substituted divalent aliphatic hydrocarbon group; and M4 represents an optionally substituted divalent aliphatic hydrocarbon group] or a salt of the compound. They are useful as a preventive/therapeutic agent for abnormal lipid metabolism, arteriosclerotic diseases, secondary diseases thereof, diabetes, etc.
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公开(公告)号：EP1559422A4
公开(公告)日：2010-02-24
申请号：EP03810621
申请日：2003-11-06
发明人： FUKATSU KOHJI , SASAKI SHINOBU , HINUMA SHUJI , ITO YASUAKI , SUZUKI NOBUHIRO , HARADA MASATAKA , YASUMA TSUNEO
IPC分类号： C07C59/68 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/401 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P7/10 , A61P9/10 , A61P9/12 , A61P13/12 , A61P15/08 , A61P17/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/28 , A61P27/02 , A61P35/00 , A61P37/08 , A61P43/00 , C07C59/64 , C07C59/72 , C07C59/74 , C07C59/76 , C07C59/90 , C07C65/24 , C07C65/26 , C07C69/734 , C07C69/736 , C07C217/48 , C07C217/58 , C07C217/76 , C07C235/42 , C07C255/24 , C07C255/54 , C07C317/28 , C07C323/19 , C07D209/12 , C07D277/24 , C07D277/36 , C07D277/42 , C07D277/44 , C07D277/64 , C07D295/13 , C07D307/80 , C07D307/91 , C07D333/32 , C07D333/54 , C07D333/62 , C07D333/78 , C07D471/04
CPC分类号： C07C255/24 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/401 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/437 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/74 , C07C59/76 , C07C59/90 , C07C65/24 , C07C69/734 , C07C69/736 , C07C217/48 , C07C217/58 , C07C217/76 , C07C235/42 , C07C255/54 , C07C317/28 , C07C323/19 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D209/12 , C07D277/36 , C07D277/42 , C07D277/64 , C07D295/13 , C07D307/91 , C07D333/32 , C07D333/54 , C07D333/62 , C07D333/78 , C07D471/04
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公开(公告)号：EP1630152A4
公开(公告)日：2009-09-23
申请号：EP04745580
申请日：2004-05-28
发明人： YASUMA TSUNEO , NEGORO NOBUYUKI , FUKATSU KOHJI
IPC分类号： C07C59/68 , A61K31/192 , A61K31/343 , A61K31/427 , A61K31/428 , A61P3/10 , C07C59/64 , C07C59/72 , C07C65/26 , C07C69/734 , C07C69/736 , C07D209/12 , C07D277/42 , C07D277/44 , C07D277/64 , C07D307/80
CPC分类号： C07C69/734 , C07C59/64 , C07C59/68 , C07C59/72 , C07C2601/02 , C07C2602/10 , C07D277/42
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公开(公告)号：EP1661898A4
公开(公告)日：2009-04-15
申请号：EP04772639
申请日：2004-08-26
发明人： FUKATSU KOHJI , NAKAYAMA YUTAKA , TARUI NAOKI , MORI MASAAKI , MATSUMOTO HIROKAZU , KURASAWA OSAMU , BANNO HIROSHI
IPC分类号： C07D498/04 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P1/14 , A61P3/06 , A61P3/10 , A61P5/00 , A61P5/14 , A61P5/24 , A61P9/12 , A61P25/28 , A61P35/00 , A61P43/00 , C07D487/04 , C07D513/04
CPC分类号： C07D487/04 , C07D513/04
摘要： A compound represented by the formula (I) (wherein R1 represents acyl; R2 represents an optionally substituted hydrocarbon group, etc.; R3 represents an optionally substituted hydrocarbon group, etc.; R4 represents an optionally substituted hydrocarbon group, etc.; n is 0 to 4; and X represents oxygen, sulfur, etc.) or a salt of the compound. The compound has TGR23 antagonistic activity and is useful in the prevention of and treatments for cancers.
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