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公开(公告)号：EP1165501A1
公开(公告)日：2002-01-02
申请号：EP00912064.3
申请日：2000-03-01
发明人： NATCHUS, Michael, George , BOOKLAND, Roger Gunnard , ALMSTEAD, Neil, Gregory , PIKUL, Stanislaw , DE, Biswanath , CHENG, Menyan
IPC分类号： C07C311/19 , C07C311/29 , A61K31/18 , A61P19/02 , C07D295/155 , C07D317/56 , C07D295/088 , C07D213/55 , C07D307/54 , C07D333/24 , C07D207/337 , C07D333/34 , C07D295/185 , C07D295/26 , C07D413/04
CPC分类号： C07D207/337 , A61K31/5375 , C07C311/21 , C07C311/29 , C07C311/42 , C07C311/46 , C07C311/47 , C07C323/58 , C07C323/67 , C07D209/42 , C07D213/55 , C07D213/81 , C07D213/82 , C07D285/135 , C07D295/088 , C07D295/145 , C07D295/185 , C07D295/192 , C07D295/195 , C07D295/26 , C07D307/54 , C07D317/48 , C07D333/24 , C07D333/34 , C07D413/04
摘要： Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I) where X, W, Z, A, G, R?1, R2, R3, R4, R5, R5'¿ and k have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of said formula, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
摘要翻译： 公开了作为金属蛋白酶抑制剂的化合物，其可有效治疗以这些酶的活性过高为特征的病症。 特别地，所述化合物具有根据式（I）的结构，其中X，W，Z，A，G，R 1，R 2，R 3，R 4，R 5，R 5'和k具有说明书中所述的含义。 本发明还包括所述式的光学异构体，非对映异构体和对映异构体及其药学上可接受的盐，可生物水解的酰胺，酯和酰亚胺。 还描述了包含这些化合物的药物组合物，以及使用该化合物或药物组合物治疗或预防金属蛋白酶相关疾病的方法。
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2.发明公开SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS 失效硫代氨基甲酸替代羟丙基氨基酸衍生物
公开(公告)号：EP1009737A2
公开(公告)日：2000-06-21
申请号：EP98932460.3
申请日：1998-07-27
发明人： ALMSTEAD, Neil, Gregory , BOOKLAND, Roger, Gunnard , TAIWO, Yetunde, Olabisi , BRADLEY, Rimma, Sandler , BUSH, Rodney, Dean , DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw
IPC分类号： C07C323/60
CPC分类号： C07D207/412 , C07C311/14 , C07C311/19 , C07C311/29 , C07C317/48 , C07C323/60 , C07C323/61 , C07C2601/14 , C07C2602/42 , C07D209/48 , C07D211/54 , C07D211/84 , C07D213/82 , C07D233/74 , C07D277/46 , C07D309/08 , C07D335/02 , C07F9/36 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/887 , Y10S514/902 , Y10S514/903
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
摘要翻译： 本发明提供了权利要求中描述的式的化合物或其旋光异构体，非对映异构体或其对映异构体或其药学上可接受的盐或可生物水解的酰胺，酯或酰亚胺可用作金属蛋白酶的抑制剂。还公开了药物组合物和 使用这些化合物治疗以金属蛋白酶活性为特征的疾病，病症和病症的方法或含有它们的药物组合物。
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公开(公告)号：EP0927183A1
公开(公告)日：1999-07-07
申请号：EP97939445.0
申请日：1997-08-22
发明人： WANG, Zhe , ALMSTEAD, Neil, Gregory , BRADLEY, Rimma, Sandler , NATCHUS, Michael, George , DE, Biswanath , PIKUL, Stanislaw , TAIWO, Yetunde, Olabisi
IPC分类号： C07D487 , A61K31 , A61P1 , A61P3 , A61P7 , A61P9 , A61P11 , A61P13 , A61P15 , A61P17 , A61P19 , A61P21 , A61P25 , A61P27 , A61P29 , A61P31 , A61P33 , A61P35 , A61P37 , A61P39 , A61P41 , A61P43 , C07D207 , C07D209 , C07D471 , C07D491 , C07D493 , C07D495
CPC分类号： C07D471/10 , C07D209/96 , C07D491/10 , C07D495/10
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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公开(公告)号：EP1165530A2
公开(公告)日：2002-01-02
申请号：EP00915936.9
申请日：2000-03-01
发明人： CHENG, Menyan , ALMSTEAD, Neil, Gregory , NATCHUS, Michael, George , PIKUL, Stanislaw , DE, Biswanath
IPC分类号： C07D277/36 , C07C311/19 , C07D249/12 , A61K31/41 , A61K31/426 , C07D233/84 , C07D235/28 , C07D239/95 , C07D277/74 , A61K31/428 , C07D263/58 , C07D257/04 , A61K31/433 , C07D285/125 , C07D333/34 , C07D271/113 , C07D413/04 , C07D307/64 , C07D239/38 , C07D213/70 , C07D487/04
CPC分类号： C07D213/70 , C07C311/29 , C07C317/48 , C07C323/58 , C07D213/65 , C07D233/84 , C07D235/28 , C07D239/95 , C07D249/10 , C07D257/04 , C07D263/58 , C07D271/113 , C07D277/74 , C07D285/08 , C07D307/38 , C07D311/16 , C07D333/34 , C07D413/04 , C07D473/36
摘要： Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to formula (I): where J, M, Q, T, W, X, Z, R?1, R2, R3, R4, R4', R5, R6, R6', R7¿, m, and n have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also disclosed are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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公开(公告)号：EP0925287A1
公开(公告)日：1999-06-30
申请号：EP97939442.0
申请日：1997-08-22
发明人： DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabisi , CHENG, Menyan
IPC分类号： C07D243 , A61K31 , A61P1 , A61P9 , A61P11 , A61P15 , A61P17 , A61P19 , A61P27 , A61P29 , A61P31 , A61P35 , A61P37 , A61P39 , A61P43 , C07D223 , C07D241 , C07D265 , C07D279 , C07D281 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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公开(公告)号：EP0925287B1
公开(公告)日：2003-01-15
申请号：EP97939442.6
申请日：1997-08-22
发明人： DE, Biswanath , NATCHUS, Michael, George , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , MATTHEWS, Randall, Stryker , TAIWO, Yetunde, Olabisi , CHENG, Menyan
IPC分类号： C07D243/08 , C07D267/10 , C07D281/04 , C07D281/18 , A61K31/53 , A61K31/54
CPC分类号： C07D265/30 , C07D223/06 , C07D241/04 , C07D241/08 , C07D279/12 , C07D281/00 , C07D281/06 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/12 , Y02P20/582
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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7.发明公开HETEROCYCLIC SIDE CHAIN CONTAINING, N-SUBSTITUTED METALLOPROTEASE INHIBITORS 审中-公开杂环侧链ENHALTENDE，N-取代的金属蛋白酶
公开(公告)号：EP1265864A1
公开(公告)日：2002-12-18
申请号：EP01918867.1
申请日：2001-03-02
发明人： PIKUL, Stanislaw , OHLER, Norman, Eugene , ALMSTEAD, Neil, Gregory , LAUGHLIN, Steven, Karl , NATCHUS, Michael, George , DE, Biswanath
IPC分类号： C07D211/34 , C07D211/96 , C07D211/66 , C07D309/14 , C07D309/08 , C07D309/06 , C07D407/12 , C07D401/12 , A61K31/445 , A61K31/535 , A61K31/35
CPC分类号： C07D401/12 , C07D211/34 , C07D211/66 , C07D211/96 , C07D309/06 , C07D309/08 , C07D309/14 , C07D407/12
摘要： Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I): where R?1, R2, R3¿, n, A, E, X, G, G', M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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公开(公告)号：EP0927168B1
公开(公告)日：2002-11-06
申请号：EP97937317.2
申请日：1997-08-22
发明人： PIKUL, Stanislaw , MCDOW-DUNHAM, Kelly, Lynn , ALMSTEAD, Neil, Gregory , DE, Biswanath , NATCHUS, Michael, George , TAIWO, Yetunde, Olabisi
IPC分类号： C07D239/04 , C07D239/06 , C07D279/06 , C07D277/06 , A61K31/495
CPC分类号： C07D239/10 , C07D233/02 , C07D233/38 , C07D239/04 , C07D243/04 , C07D265/06 , C07D265/14 , C07D277/06 , C07D279/06 , C07D409/14 , C07D413/14 , C07D487/04 , C07D495/10
摘要： The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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公开(公告)号：EP0927161B1
公开(公告)日：2002-10-16
申请号：EP97938412.0
申请日：1997-08-22
发明人： NATCHUS, Michael, George , DE, Biswanath , PIKUL, Stanislaw , ALMSTEAD, Neil, Gregory , BOOKLAND, Roger, Gunnard , TAIWO, Yetunde, Olabisi , CHENG, Menyan
IPC分类号： C07D207/48 , A61K31/40 , C07D417/04 , C07D403/04 , C07D401/04 , C07D403/12 , C07D401/12 , C07D409/14 , C07D413/14 , C07D405/12
CPC分类号： C07D207/42
摘要： The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to formula (I). Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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公开(公告)号：EP1224171A1
公开(公告)日：2002-07-24
申请号：EP00970820.7
申请日：2000-10-12
发明人： PIKUL, Stanislaw , OHLER, Norman, Eugene , SOLINSKY, Kelly, Michelle , ALMSTEAD, Neil, Gregory , DE, Biswanath , NATCHUS, Michael, George
IPC分类号： C07D213/70 , C07D239/38 , C07D277/36 , C07D233/84 , C07D263/46 , C07D249/12 , C07D213/32 , C07D263/32 , C07D213/76 , C07D333/18 , A61K31/18 , A61K31/505
CPC分类号： C07D239/22 , C07C311/19 , C07C311/29 , C07C323/59 , C07D233/80 , C07D233/86 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/06 , C07D471/04 , C07D513/04
摘要： Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I), wherein R?1, R2, R3, R4, R5, R6¿, G and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula (I), and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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