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47 条记录 (耗时 0.021 秒)

    Smooth muscle mitogen and DNA coding therefor
    2.
    发明公开
    Smooth muscle mitogen and DNA coding therefor 失效
    丝丝霉素fuc die fat die glatte Muskulatur und dessen kodierende DNS。

    公开(公告)号：EP0555785A1

    公开(公告)日：1993-08-18

    申请号：EP93101871.7

    申请日：1993-02-06

    申请人： Takeda Chemical Industries, Ltd. ,  CHILDREN'S MEDICAL CENTER CORPORATION

    发明人： Folkmann, Moses Judah ,  Shing, Yuen ,  Igarashi, Koichi

    IPC分类号： C12N15/18 ,  C07K15/06

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： A recombinant non-glycosylated mammalian growth factor (BTC-GF) stimulates proliferation of human smooth muscle cells. Especially, the amino acid sequence of the protein deduced from the nucleotide sequence coding for human BTC-GF is as that comprising the amino acids No. 1 to No. 147 of Figure 10 or the amino acids No. 1 to 80 of Figure 10, and the amino acid sequence of the protein deduced from the nucleotide sequence coding for mouse BTC-GF is as that comprising the amino acids No. 1 to No. 146 of Figure 9.

    摘要翻译： 重组非糖基化哺乳动物生长因子（BTC-GF）刺激人平滑肌细胞的增殖。 特别地，从编码人BTC-GF的核苷酸序列推测的蛋白质的氨基酸序列是包含图10的氨基酸No.1至No.147或图10的氨基酸No.1至80， 并且从编码小鼠BTC-GF的核苷酸序列推测的蛋白质的氨基酸序列是包含图9的第1至第146号氨基酸的氨基酸序列。

    hst-2 Mutein, DNA coding for the same and preparation thereof
    3.
    发明公开
    hst-2 Mutein, DNA coding for the same and preparation thereof 失效
    HST-2 Mutein，dafürkodierende DNS和Herstellung。

    公开(公告)号：EP0613946A2

    公开(公告)日：1994-09-07

    申请号：EP94102093.5

    申请日：1994-02-11

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD. ,  PRESIDENT OF NATIONAL CANCER CENTER

    发明人： Yoshimura, Koji ,  Ishimaru, Kaori ,  Igarashi, Koichi ,  Tereda, Masaaki

    IPC分类号： C12N15/16 ,  C07K13/00 ,  A61K37/24 ,  C12N1/21

    CPC分类号： C07K14/50 ,  A61K38/00

    摘要： The present invention provides a polypeptide represented by the following amino acid sequence:
    wherein n is 0 or 1 and X represents
    or a fragment thereof (n = 0: SEQ ID NO:1, n = 1: SEQ ID NO:2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant.
    The invention also provides a method for promoting an increase in the number of platelets in a mammal using a polypeptide having a heparin binding secretory transforming factor 2 (hst-2) activity.
    The polypeptide can be produced in large amounts, and has hst-2 activity, so that it can be advantageously used as drugs for promoting treatment of burns, wounds, etc., and therapeutic agents for gastrointestinal ulcers. Further, it can be utilized as platelet-increasing agents.

    摘要翻译： 本发明提供由以下氨基酸序列表示的多肽：其中n为0或1，X代表其片段（n = 0：SEQ ID NO：1，n = 1：SEQ ID NO： NO：2），编码该多肽的重组DNA，含有该重组DNA的载体，携带该载体的转化体的制备以及与转化体的多肽的产生。 本发明还提供使用具有肝素结合分泌转化因子2（hst-2）活性的多肽促进哺乳动物血小板数量增加的方法。 该多肽可以大量生产，并具有hst-2活性，因此可有利地用作促进烧伤，伤口等治疗药物和胃肠溃疡治疗剂的药物。 此外，它可以用作血小板递增剂。

    Monoclonal antibody against an acidic FGF protein, its production and use
    4.
    发明公开
    Monoclonal antibody against an acidic FGF protein, its production and use 失效
    MonokeparerAntikörpergegen sauren FGF，seine Herstellung und Verwendung。

    公开(公告)号：EP0420081A1

    公开(公告)日：1991-04-03

    申请号：EP90118234.5

    申请日：1990-09-22

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Ichimori, Yuzo ,  Kondo, Koichi ,  Igarashi, Koichi ,  Senoo, Masaharu

    IPC分类号： C12P21/08 ,  C12N5/18 ,  G01N33/577 ,  G01N33/68 ,  C07K3/20

    CPC分类号： C07K14/501 ,  C07K16/22

    摘要： The present invention provides a hybrid cell line producing monoclonal antibody to an acidic fibroblast growth factor (aFGF) protein. The hybridoma is established by fusing spleen cells from immunized mice with myeloma cells. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for aFGF protein.
    Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.

    摘要翻译： 本发明提供了产生对酸性成纤维细胞生长因子（aFGF）蛋白质的单克隆抗体的杂交细胞系。 通过将来自免疫小鼠的脾细胞与骨髓瘤细胞融合来建立杂交瘤。 将杂交瘤作为克隆进行培养，并测试从各克隆获得的抗体对aFGF蛋白的特异性。 抗体可以从培养生长培养基或携带杂交瘤肿瘤的小鼠的腹水获得。 还公开了单克隆抗体的诊断和治疗用途。

    Human basic fibroblast growth factor
    5.
    发明公开
    Human basic fibroblast growth factor 失效
    Menschlicher基因成纤维细胞-Wachstumsfaktor。

    公开(公告)号：EP0237966A2

    公开(公告)日：1987-09-23

    申请号：EP87103601.8

    申请日：1987-03-12

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Kurokawa, Tsumotu ,  Sasada, Reiko ,  Iwane, Makoto ,  Igarashi, Koichi

    IPC分类号： C12P21/02 ,  C07K15/00 ,  C07K3/20

    CPC分类号： C07K14/503

    摘要： A human basic fibroblast growth factor (hbFGF), which is usable for a cure promoter for burns etc., therapeutic agent for thrombosis etc. or a reagent for promoting cell cultivation, can be produced in a large quantity by cultivating a transformant as transformed with a vector including a DNA coding the hbFGF.

    摘要翻译： 可以通过培养转化的转化体，大量生产可用于烧伤治愈促进剂等的人类碱性成纤维细胞生长因子（hbFGF），血栓形成治疗剂等或促进细胞培养的试剂。 包括编码hbFGF的DNA的载体。

    Novel transformant and use thereof
    7.
    发明公开
    Novel transformant and use thereof 失效
    变形与德文Verwendung。

    公开(公告)号：EP0172619A1

    公开(公告)日：1986-02-26

    申请号：EP85304383.4

    申请日：1985-06-19

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Sasada, Reiko ,  Onda, Haruo ,  Igarashi, Koichi

    IPC分类号： C12N15/00 ,  C12N5/00 ,  C12N7/00 ,  C12P21/02 ,  C07K3/00 ,  C07K13/00

    CPC分类号： C07K14/55

    摘要： This invention relates to animal cells transformed with a DNA having a region coding for a human IL-2 protein and, upstream therefrom, at least one promoter and to a method of producing such human IL-2 protein which comprises cultivating said transformants to thereby cause production and accumulation of said protein in the culture and recovering the same.

    摘要翻译： 本发明涉及用编码人IL-2蛋白的区域及其上游的至少一种启动子的DNA转化的动物细胞，以及生产这种人IL-2蛋白质的方法，包括培养所述转化体从而引起 所述蛋白质在培养物中的产生和积累并恢复。

    Rat protein kinare C and production thereof
    8.
    发明公开
    Rat protein kinare C and production thereof 失效
    Rattenproteinkinase C und Verfahren zur Herstellung

    公开(公告)号：EP0686695A1

    公开(公告)日：1995-12-13

    申请号：EP95112109.4

    申请日：1987-06-26

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Ono, Yoshitaka ,  Kurokawa, Tsutomu ,  Igarashi, Koichi ,  Nishizuka, Yasutomi

    IPC分类号： C12N15/00 ,  C12N9/12 ,  C12N1/00

    CPC分类号： C12N9/1205 ,  C12N9/12 ,  G01N33/573

    摘要： Rat protein kinase C, recombinant DNA containing DNA sequence coding for rat kinase C, a transformant transformed with a vector containing the above recombinant DNA, and the production method of rat kinase C cultivating the transformant are disclosed. Rat kinase C is useful as reagent for studying cellular signal transduction mechanism, as diagnostic and inspection agent for disease, for example tumor, resulting from the trouble of cellular signal transduction mechanism, and as screening agent for a preventive agent or medicine to the disease.

    摘要翻译： 公开了大鼠蛋白激酶C，含有编码大鼠激酶C的DNA序列的重组DNA，用含有上述重组DNA的载体转化的转化体，以及培养转化体的大鼠激酶C的制备方法。 大鼠激酶C可用作研究细胞信号转导机制的试剂，作为由细胞信号转导机制引起的疾病，例如肿瘤的诊断和检查剂，以及作为该疾病的预防剂或药物的筛选剂。