-
公开(公告)号：EP3576742A1
公开(公告)日：2019-12-11
申请号：EP18704189.2
申请日：2018-02-01
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
发明人： LEWIS, Timothy, A. , WU, Xiaoyun , GREULICH, Heidi , MEYERSON, Matthew , ELLERMANN, Manuel , LIENAU, Philip , EIS, Knut , WENGNER, Antje, Margret , KOPITZ, Charlotte, Christine , LANGE, Martin
IPC分类号： A61K31/501 , C07D413/10 , A61P35/00
-
2.发明公开
公开(公告)号：EP3411037A1
公开(公告)日：2018-12-12
申请号：EP17704195.1
申请日：2017-02-03
申请人： Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana Farber Cancer Institute, Inc.
发明人： WENGNER, Antje, Margret , EIS, Knut , LIENAU, Philip , SACK, Ulrike , LANGE, Martin , GREULICH, Heidi , MEYERSON, Matthew , DE WAAL, Luc , SCHENONE, Monica , BURGIN, Alex , LEWIS, Timothy, A. , WU, Xiaoyun
IPC分类号： A61K31/50 , A61K31/5375 , A61K45/00 , G01N33/68 , A61P35/00
CPC分类号： A61K31/50 , A61K31/5375 , A61P35/00 , G01N33/68 , G01N2333/4703 , G01N2333/916 , G01N2800/52
摘要： The present invention features improved Compounds, especially (I) methods of identifying patients having Cancer using biomarkers (e.g., PDE3A, SLFN12 and/or CREB3Ll) that correlate with drug sensitivity and consequently treating a stratified patient population with an agent of the invention (e.g., Compounds 1-6 disclosed herein).
-
公开(公告)号：EP4301371A1
公开(公告)日：2024-01-10
申请号：EP22710550.9
申请日：2022-03-02
发明人： LANGE, Martin , KAULFUSS, Stefan , KOPITZ, Charlotte Christine , GREULICH, Heidi , WU, Xiaoyun , MEYERSON, Matthew
IPC分类号： A61K31/5395 , A61P35/00
-
公开(公告)号：EP3917915A1
公开(公告)日：2021-12-08
申请号：EP20703003.2
申请日：2020-01-30
发明人： GRADL, Stefan, Nikolaus , ELLERMANN, Manuel , LIENAU, Philip , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , SÜLZLE, Detlev , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D253/06 , C07D403/10 , C07D403/12 , C07C229/08 , A61P35/00 , A61K31/53
-
公开(公告)号：EP4260909A3
公开(公告)日：2024-03-20
申请号：EP23189515.2
申请日：2015-11-25
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , NUBBEMEYER, Reinhard , BÖMER, Ulf , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , STEGMANN, Christian , SUTTER, Andreas , RAUSCH, Alexandra , FRIEDRICH, Christian , HAUFF, Peter
IPC分类号： A61P35/00 , A61P19/02 , A61P9/00 , A61P17/00 , A61P29/00 , C07D401/12 , C07D405/14 , A61K31/4439
摘要： Die vorliegende Anmeldung betrifft neue substituierte Indazole, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Behandlung und/oder Prophylaxe von Endometriose sowie Endometriose-assoziierter Schmerzen und anderer Endometriose-assoziierter Symptome wie Dysmenorrhoe, Dyspareunie, Dysurie und Dyschezie, von Lymphomen, Rheumatoider Arthritis, Spondyloarthritiden (insbesondere Spondyloarthritis psoriatica und Morbus Bechterew), Lupus erythematodes, Multipler Sklerosis, Makuladegeneration, COPD, Gicht, Fettlebererkrankungen, Insulinresistenz, Tumorerkrankungen und Psoriasis.
-
公开(公告)号：EP3288558A1
公开(公告)日：2018-03-07
申请号：EP16723280.0
申请日：2016-04-29
发明人： BOTHE, Ulrich , WENGNER, Antje Margret , SIEBENEICHER, Holger , SCHMIDT, Nicole , NUBBEMEYER, Reinhard , BÖMER, Ulf , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , STEGMANN, Christian , SUTTER, Andreas , NEUHAUS, Roland
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , C07D401/12 , A61P35/02 , A61P35/00
CPC分类号： A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P35/00 , A61K2300/00
摘要： The present application relates to novel combinations of at least two components, component A and component B: ⋅component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; ⋅component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, ⋅one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
-
7.发明公开NEUE INDAZOLCARBOXAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE DIE DIESE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权新INDAZOLCARBOXAMIDE，用于生产药物制剂含它们，它们在药品生产
公开(公告)号：EP3083586A1
公开(公告)日：2016-10-26
申请号：EP14824414.8
申请日：2014-12-16
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , ROTGERI, Andrea , BÖMER, Ulf , RING, Sven , IRLBACHER, Horst , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , SCHÄFER, Martina
IPC分类号： C07D401/12 , C07D401/14 , C07D417/12 , C07D409/12 , A61K31/4439 , A61K31/444 , A61P37/00 , A61P29/00
CPC分类号： C07D495/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/10 , C07D491/107
摘要： The invention relates to a novel 6-substituted indazoles with carboxamide side chains, method for the production thereof, to the use thereof alone or in combinations for treating and/or the prophylaxis of diseases and to the use thereof for producing medicaments for treating and/or the prophylaxis of diseases, in particular for treating and/or the prophylaxis of endometriosis, preventing lymphomas, macular degeneration, COPD and psoriasis.
-
公开(公告)号：EP3224254B1
公开(公告)日：2020-04-15
申请号：EP15800828.4
申请日：2015-11-25
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , NUBBEMEYER, Reinhard , BÖMER, Ulf , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , STEGMANN, Christian , SUTTER, Andreas , RAUSCH, Alexandra , HAUFF, Peter , FRIEDRICH, Christian
IPC分类号： C07D401/12 , A61K31/4439 , A61P9/00 , A61P17/00 , A61P29/00 , A61P35/00
-
公开(公告)号：EP3515911A1
公开(公告)日：2019-07-31
申请号：EP17764848.2
申请日：2017-09-15
发明人： LANGE, Martin
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P35/00
-
10.发明授权NEUE INDAZOLCARBOXAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE DIE DIESE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 有权新INDAZOLCARBOXAMIDE，用于生产药物制剂含它们，它们在药品生产
公开(公告)号：EP3083586B1
公开(公告)日：2018-04-18
申请号：EP14824414.8
申请日：2014-12-16
发明人： BOTHE, Ulrich , SIEBENEICHER, Holger , SCHMIDT, Nicole , ROTGERI, Andrea , BÖMER, Ulf , RING, Sven , IRLBACHER, Horst , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , SCHÄFER, Martina
IPC分类号： C07D401/12 , C07D401/14 , C07D417/12 , C07D409/12 , A61K31/4439 , A61K31/444 , A61P37/00 , A61P29/00
CPC分类号： C07D495/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D487/10 , C07D491/107
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.034 秒)
