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公开(公告)号：EP3576742A1
公开(公告)日：2019-12-11
申请号：EP18704189.2
申请日：2018-02-01
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
发明人： LEWIS, Timothy, A. , WU, Xiaoyun , GREULICH, Heidi , MEYERSON, Matthew , ELLERMANN, Manuel , LIENAU, Philip , EIS, Knut , WENGNER, Antje, Margret , KOPITZ, Charlotte, Christine , LANGE, Martin
IPC分类号： A61K31/501 , C07D413/10 , A61P35/00
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公开(公告)号：EP3917915A1
公开(公告)日：2021-12-08
申请号：EP20703003.2
申请日：2020-01-30
发明人： GRADL, Stefan, Nikolaus , ELLERMANN, Manuel , LIENAU, Philip , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , SÜLZLE, Detlev , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D253/06 , C07D403/10 , C07D403/12 , C07C229/08 , A61P35/00 , A61K31/53
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公开(公告)号：EP3215505B1
公开(公告)日：2019-07-24
申请号：EP15788013.9
申请日：2015-10-30
发明人： ELLERMANN, Manuel , VALOT, Gaelle , CANCHO GRANDE, Yolanda , HAßFELD, Jorma , KINZEL, Tom , KÖBBERLING, Johannes , BEYER, Kristin , RÖHRIG, Susanne , SPERZEL, Michael , STAMPFUß, Jan , MEYER, Imke , KÖLLNBERGER, Maria , BURKHARDT, Nils , SCHLEMMER, Karl-Heinz , STEGMANN, Christian , SCHUHMACHER, Joachim , WERNER, Matthias , HEIERMANN, Jörg , HENGEVELD, Willem Jan
IPC分类号： C07D487/04 , A61K31/519 , A61P7/04
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公开(公告)号：EP3049390A1
公开(公告)日：2016-08-03
申请号：EP14771910.8
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert, Alan , SCHMIDT, Martina, Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D209/42 , A61P7/02 , A61K31/16 , C07D231/56 , C07D235/08 , C07D235/26 , C07D249/08 , C07D249/10 , C07D257/04 , C07D263/58 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , C07D209/42 , C07D231/56 , C07D235/08 , C07D235/26 , C07D249/04 , C07D249/08 , C07D249/10 , C07D257/04 , C07D263/58 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D487/04
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 除了使用所述衍生物生产用于治疗和/或预防疾病，特别是心血管疾病和/或围手术期严重失血的药物之外，本发明涉及取代的苯丙氨酸衍生物和其制备方法。
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公开(公告)号：EP3049403A1
公开(公告)日：2016-08-03
申请号：EP14776625.7
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRAßBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , A61K31/16 , A61P7/04
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
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6.发明公开SUBSTITUIERTE PHENYLALANIN-DERIVATE ALS FAKTOR XIA MODULATOREN 审中-公开SUBSTITUIERTE苯丙氨酸衍生物ALS FAKTOR XIA MODULATOREN
公开(公告)号：EP3049394A1
公开(公告)日：2016-08-03
申请号：EP14771913.2
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D257/04 , C07D413/12 , C07D403/12 , C07D235/26 , C07D401/12 , C07D271/07 , A61K31/41 , A61K31/5377 , A61K31/4184 , A61K31/454 , A61K31/4245 , A61P7/00 , A61P9/00
CPC分类号： C07D413/12 , C07D231/56 , C07D235/10 , C07D235/26 , C07D249/10 , C07D249/12 , C07D257/04 , C07D271/07 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 除了使用所述衍生物制备用于治疗和/或预防疾病，特别是心血管疾病和/或围手术期严重失血的药物之外，本发明涉及取代的苯丙氨酸衍生物和其制备方法。
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公开(公告)号：EP3066100B1
公开(公告)日：2019-04-17
申请号：EP14793523.3
申请日：2014-11-03
发明人： HASSFELD, Jorma , KINZEL, Tom , KÖBBERLING, Johannes , CANCHO GRANDE, Yolanda , BEYER, Kristin , RÖHRIG, Susanne , KÖLLNBERGER, Maria , SPERZEL, Michael , BURKHARDT, Nils , SCHLEMMER, Karl-Heinz , STEGMANN, Christian , SCHUHMACHER, Joachim , WERNER, Matthias , ELLERMANN, Manuel
IPC分类号： C07D487/04 , C07D487/12 , A61K31/519 , A61P7/04
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公开(公告)号：EP3215505A1
公开(公告)日：2017-09-13
申请号：EP15788013.9
申请日：2015-10-30
发明人： ELLERMANN, Manuel , VALOT, Gaelle , CANCHO GRANDE, Yolanda , HAßFELD, Jorma , KINZEL, Tom , KÖBBERLING, Johannes , BEYER, Kristin , RÖHRIG, Susanne , SPERZEL, Michael , STAMPFUß, Jan , MEYER, Imke , KÖLLNBERGER, Maria , BURKHARDT, Nils , SCHLEMMER, Karl-Heinz , STEGMANN, Christian , SCHUHMACHER, Joachim , WERNER, Matthias , HEIERMANN, Jörg , HENGEVELD, Willem Jan
IPC分类号： C07D487/04 , A61K31/519 , A61P7/04
CPC分类号： C07D487/04 , A61K31/519 , C07D211/06 , C07D231/00 , C07D247/02 , C07D271/06 , C07D271/10 , C07D403/14 , C07D471/04
摘要： The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
摘要翻译： 本申请涉及新的取代的哌啶基吡唑并嘧啶酮，其制备方法，所述化合物单独或组合用于治疗和/或预防疾病，特别是用于治疗和/或预防急性和复发性出血 在具有或不具有遗传性或获得性止血障碍的患者中，其中出血与选自由重度月经出血，产后出血，失血性休克，出血性膀胱炎，胃肠道出血，外伤，手术，移植组成的组的疾病或医学干预有关 ，中风，肝脏疾病，遗传性血管性水肿，流鼻血，以及关节积血后的滑膜炎和软骨损伤。
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公开(公告)号：EP3049410A1
公开(公告)日：2016-08-03
申请号：EP14772148.4
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D413/12 , C07D257/04 , C07D401/12 , A61K31/41 , A61K31/454 , A61K31/496 , A61P7/00 , A61P9/00
CPC分类号： C07D257/04 , C07D249/08 , C07D401/12 , C07D405/12 , C07D413/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
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公开(公告)号：EP3049408A1
公开(公告)日：2016-08-03
申请号：EP14772147.6
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D403/12 , C07D231/56 , C07D401/12 , C07D235/26 , C07D405/12 , C07D249/10 , C07D257/04 , A61P7/02
CPC分类号： C07D405/12 , C07D231/56 , C07D235/26 , C07D249/08 , C07D249/10 , C07D257/04 , C07D401/12 , C07D403/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 本发明涉及取代的苯丙氨酸衍生物及其制备方法，以及其用于生产用于治疗和/或预防特别是心血管疾病和/或严重围手术期失血的疾病的药物的用途。
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