专利检索 ap:("The Broad Institute, Inc." OR "President AND Fellows of Harvard College" OR "Massachusetts Institute of Technology") AND inv:"BASU, Anindita" 第 1 页

1.

发明公开
A DROPLET-BASED METHOD AND APPARATUS FOR COMPOSITE SINGLE-CELL NUCLEIC ACID ANALYSIS 审中-公开

公开(公告)号：EP4105337A1

公开(公告)日：2022-12-21

申请号：EP22175488.0

申请日：2015-09-09

申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute Of Technology

发明人： REGEV, Aviv , MACOSKO, Evan Zane , MCCARROLL, Steven Andrew , SHALEK, Alexander K , BASU, Anindita , FORD, Christopher B , PARK, Hongkun , WEITZ, David A

IPC分类号： C12Q1/68 , C12N15/10

摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

2.

发明公开
A DROPLET-BASED METHOD AND APPARATUS FOR COMPOSITE SINGLE-CELL NUCLEIC ACID ANALYSIS 审中-公开
标题翻译：基于液滴法的复合单细胞核酸分析方法及装置

公开(公告)号：EP3191605A1

公开(公告)日：2017-07-19

申请号：EP15767655.2

申请日：2015-09-09

申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology

发明人： REGEV, Aviv , MACOSKO, Evan, Zane , MCCARROLL, Steven, Andrew , SHALEK, Alexander, K. , BASU, Anindita , FORD, Christopher, B. , PARK, Hongkun , WEITZ, David, A.

IPC分类号： C12Q1/68 , C12N15/10

CPC分类号： C12Q1/6809 , C12N15/1096 , C12Q1/6834 , C12Q1/6869 , G06K19/06 , C12Q2521/107 , C12Q2525/15 , C12Q2525/155 , C12Q2525/161 , C12Q2525/173 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629 , C12Q2563/179

摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

摘要翻译： 本发明总体上涉及分子条形码和基于乳液的微流体的组合，以高通量方式分离，裂解，条形码并从各个细胞制备核酸。

3.

发明公开
HIGH-THROUGHPUT DYNAMIC REAGENT DELIVERY SYSTEM 审中-公开

公开(公告)号：EP3368221A1

公开(公告)日：2018-09-05

申请号：EP16861016.0

申请日：2016-10-28

申请人： The Broad Institute Inc. , Massachusetts Institute Of Technology , President and Fellows of Harvard College , Dana-Farber Cancer Institute, Inc.

发明人： FORD, Christopher B. , WEITZ, David, A. , BASU, Anindita , REGEV, Aviv , ROTEM, Asaf , STRUHL, Kevin

IPC分类号： B01L3/00 , C12Q1/00

CPC分类号： B01L3/502715 , B01L3/0241 , B01L3/502746 , B01L2200/027 , B01L2200/10 , B01L2300/08 , B01L2300/0864 , B01L2300/0867 , B01L2400/086 , C12M23/12 , C12M23/16 , G01N33/5011 , G01N33/502

摘要： The present invention generally relates to a controlled fluidic device to develop spatially complex environments to enhance the rate of evolution in cell populations. The method further provides an enhanced understanding in the emergence, for example, drug resistance during cancer chemotherapy.