公开(公告)号：EP3368221A1

公开(公告)日：2018-09-05

申请号：EP16861016.0

申请日：2016-10-28

申请人： The Broad Institute Inc. ,  Massachusetts Institute Of Technology ,  President and Fellows of Harvard College ,  Dana-Farber Cancer Institute, Inc.

发明人： FORD, Christopher B. ,  WEITZ, David, A. ,  BASU, Anindita ,  REGEV, Aviv ,  ROTEM, Asaf ,  STRUHL, Kevin

IPC分类号： B01L3/00 ,  C12Q1/00

CPC分类号： B01L3/502715 ,  B01L3/0241 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/08 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/086 ,  C12M23/12 ,  C12M23/16 ,  G01N33/5011 ,  G01N33/502

摘要： The present invention generally relates to a controlled fluidic device to develop spatially complex environments to enhance the rate of evolution in cell populations. The method further provides an enhanced understanding in the emergence, for example, drug resistance during cancer chemotherapy.

公开(公告)号：EP3058367A2

公开(公告)日：2016-08-24

申请号：EP14877132.2

申请日：2014-10-16

申请人： President and Fellows of Harvard College

发明人： JAIN, Abhishek ,  WATERHOUSE, Anna ,  SUPER, Mike ,  INGBER, Donald E. ,  LESLIE, Daniel C.

IPC分类号： G01N33/49 ,  G01N33/86

CPC分类号： B01L3/50273 ,  B01L3/502746 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0478 ,  B01L2400/084 ,  G01N33/4905 ,  G01N33/86 ,  G06F19/24

摘要： In accord with one aspect, a microfluidic coagulation assessment device defining a plurality of microchannels is provided, wherein a blood sample is driven through the microchannels at a substantially constant flow rate and a controller is configured to, in combination with a timer and a pressure sensing device, determine a first pressure value (or flow value) at an initiation of flow, a first time (Tpg) at which a second pressure value is about twice the determined first pressure value, and a second time (Tpf) at which a third pressure value is about (1+e) times the determined first pressure value and establish a subject coagulation model predictive of channel occlusion therefrom. In another aspect, the blood sample is driven through the microchannels at a substantially constant pressure and a controller is configured to, in combination with a timer and a flow sensing device make the determination based on flow rate.

公开(公告)号：EP1709750A1

公开(公告)日：2006-10-11

申请号：EP05706054.3

申请日：2005-01-24

申请人： Peeters, John P.

发明人： Peeters, John P.

IPC分类号： H04B7/00 ,  C12Q1/00 ,  C12M3/00 ,  G08B1/08 ,  G08B21/00 ,  G08B23/00 ,  G08C15/00

CPC分类号： A61B5/02028 ,  A61B5/0002 ,  A61B5/0008 ,  A61B5/02 ,  A61B5/1112 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1491 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150793 ,  A61B5/150854 ,  A61B5/15087 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/157 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/6832 ,  A61B5/6833 ,  A61B90/98 ,  A61B2560/0242 ,  A61B2560/0285 ,  A61B2560/0412 ,  A61B2560/0462 ,  A61B2562/08 ,  A62B99/00 ,  B01L2300/08 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0825 ,  G01D21/00 ,  G01K13/00 ,  G01N33/02 ,  G01N33/146 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/58 ,  G01N35/00871 ,  G01N2035/00881 ,  G06K19/0717 ,  G06K19/0723 ,  G08B31/00 ,  H04M1/7253 ,  H04M2250/02 ,  H04W64/00 ,  H04W80/00 ,  H04W84/18 ,  H04W88/02 ,  H04W88/06 ,  Y02A30/50

摘要： An integrated passive wireless chip diagnostic immunoassay sensor system is described that can be interrogated remotely with a wireless devicesuch as a modified cell phone incorporating multi-protocol RFID reader capabilities (such as the emerging Gen-2 standard) or Bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as microfluidic sensor technologies. Applications of the present invention include on-the-spot medical and selfdiagnostics on smart skin patches, Point of Care (POC) analyses, food diagnostics, pathogen detection, disease-specific wireless biomarker detection, remote structural stresses detection and sensor networks for industrial or Homeland Security using low cost wireless devices such as modified cell phones.

公开(公告)号：EP3505489A1

公开(公告)日：2019-07-03

申请号：EP17843275.3

申请日：2017-07-21

申请人： Sony Corporation

发明人： KOJIMA, Kensuke ,  MASUHARA, Shin ,  WATANABE, Toshio

IPC分类号： B81B1/00 ,  C12M1/34

CPC分类号： B01L3/502761 ,  B01L3/502738 ,  B01L2200/0668 ,  B01L2300/08 ,  B01L2400/06 ,  B81B1/00 ,  B81B1/006 ,  B81B2201/054 ,  B81B2203/0338 ,  C12M47/04 ,  G01N15/1056

摘要： Provided is a single-particle capturing apparatus in which one particle can be captured in one recess portion (16) while preventing another particle from being accumulated on a captured particle.
A single-particle capturing apparatus including:
a flow channel (12) on a substrate (11),
a wave structure with a mountain portion (13) and a valley portion (14) on the flow channel (12), and
a recess portion (16) at a top portion (15) of the mountain portion (13), the recess portion (16) including a draw-in passage (17).

公开(公告)号：EP3083059A4

公开(公告)日：2017-11-08

申请号：EP14860937

申请日：2014-10-30

申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC

发明人： BRENNAN JOSEPH ,  KEGELMAN JAMES

IPC分类号： B01L3/00 ,  G01N35/00

CPC分类号： G01N35/00663 ,  B01L3/50853 ,  B01L3/523 ,  B01L3/527 ,  B01L3/5453 ,  B01L2200/023 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/041 ,  B01L2300/042 ,  B01L2300/08 ,  B01L2300/0809 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/00673 ,  G01N2035/0405 ,  G01N2035/0413 ,  G01N2035/0443 ,  G01N2035/0455 ,  G01N2035/1032

摘要： A multi-well fluid container that includes a container body is provided for use in an in vitro diagnostics automation system. The container body includes a first well having a first well size configured to hold a first fluid and an openable first well closure that covers a first well opening. The first well opening provides access to the first fluid in the first well when the openable first well closure is opened. The container body also includes a second well having a second well size configured to hold a second fluid and having an openable second well closure that covers a second well opening. The second well opening provides access to the second fluid in the second well when the openable second well closure is opened. The first well size of the first well is different than the second well size of the second well.

公开(公告)号：EP3222352A1

公开(公告)日：2017-09-27

申请号：EP17161957.0

申请日：2017-03-21

申请人： Stratec Biomedical AG

发明人： LUKHAUB, Waldemar ,  TRUMP, Martin ,  ZIMMERMANN, Sara

IPC分类号： B01L3/00

CPC分类号： B01L3/50825 ,  B01L3/523 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/045 ,  B01L2300/049 ,  B01L2300/08 ,  B01L2300/123 ,  G01N35/1002 ,  G01N35/1079

摘要： The invention relates to a device for sealing a reagent container storing and providing liquids, in particular in an analyzer system. The invention also relates to a reagent container using such device for sealing, a cartridge for holding such reagent container, and a method for removing a liquid from such reagent container. The instant invention provides a device for sealing a reagent container comprising an annular member configured to be inserted into the reagent container, wherein the annular member is configured to being movably coupled to the reagent container relative to its longitudinal center axis; an opening passing from a top end of the annular member to a bottom end of the annular member; and a sealing element arranged between the top end and the bottom end of the annular member for sealing the opening.

摘要翻译： 本发明涉及一种用于密封储存和提供液体的试剂容器的装置，特别是在分析器系统中。 本发明还涉及一种使用这种密封装置的试剂容器，用于保持该试剂容器的盒以及从该试剂容器中取出液体的方法。 本发明提供了一种用于密封试剂容器的装置，该试剂容器包括被构造成插入试剂容器中的环形构件，其中环形构件被构造成相对于其纵向中心轴线可移动地联接到试剂容器; 从环状构件的顶端通向环状构件的底端的开口; 以及布置在环形构件的顶端和底端之间用于密封开口的密封元件。

公开(公告)号：EP3033184A4

公开(公告)日：2017-03-29

申请号：EP14836593

申请日：2014-08-15

申请人： MASSACHUSETTS INST TECHNOLOGY

发明人： SHAREI ARMON R ,  ADALSTEINSSON VIKTOR A ,  CHO NAHYUN ,  LANGER ROBERT S ,  LOVE J CHRISTOPHER ,  JENSEN KLAVS F

IPC分类号： B07B1/00 ,  B01L3/00 ,  B82Y30/00 ,  C12Q1/04 ,  G01N1/30 ,  G01N15/10 ,  G01N15/14 ,  G01N33/574

CPC分类号： B01L3/502761 ,  B01L2200/0652 ,  B01L2300/08 ,  B01L2400/0487 ,  B82Y30/00 ,  C12Q1/04 ,  G01N1/30 ,  G01N15/1459 ,  G01N15/1484 ,  G01N33/574 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1081

摘要： Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.

公开(公告)号：EP3060342A1

公开(公告)日：2016-08-31

申请号：EP14789265.7

申请日：2014-10-24

申请人： Trilobite Innovation AS

发明人： EGELAND, Eirik, Bentzen

IPC分类号： B01L3/00

CPC分类号： B01L3/502753 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/08 ,  B01L2300/0861 ,  B01L2400/084

摘要： A fluid refining device and assembly comprises an inlet for fluid to be refined, a separation outlet and a concentration outlet for processed fluid in a refining layer, wherein the refining layer comprises a plurality of refining units arranged in a pattern, and wherein the cross section of the concentration outlet is less than the cross section of the inlet.

公开(公告)号：EP2998026A2

公开(公告)日：2016-03-23

申请号：EP15182577.5

申请日：2015-08-26

申请人： Academia Sinica

发明人： CHANG, Ying-Chih ,  LAI, Jr-Ming ,  WU, Jen-Chia

IPC分类号： B01L3/00

CPC分类号： B01L3/502753 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/08 ,  B01L2300/0809 ,  B01L2300/16 ,  B01L2400/086

摘要： The disclosure provides for compositions and methods for the collection of rare cells using an interspersed microstructure design.

摘要翻译： 本公开提供了使用散布的微结构设计收集稀有电池的组合物和方法。

公开(公告)号：EP3313574A1

公开(公告)日：2018-05-02

申请号：EP16733362.4

申请日：2016-06-21

申请人： GILSON SAS

发明人： DUDEK, Bruno ,  RAMSAMY, Sanjay

IPC分类号： B01L3/02

CPC分类号： B01L3/0237 ,  B01L3/0217 ,  B01L3/0286 ,  B01L2200/0605 ,  B01L2200/087 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2300/023 ,  B01L2300/025 ,  B01L2300/0627 ,  B01L2300/08 ,  B01L2300/123

摘要： The invention relates to a control button (12) for a manually actuated sampling pipette, the button comprising lower and upper parts (24a, 24b), one of which is equipped with a force sensor (31) and the other with an actuating member (30). In the vertical position of the button, in a state not subjected to a force, not only does the member (30) ensure that the upper part is retained axially on the lower part (24a), but these parts also define a circular axially retaining connection (42) therebetween, the circular connection exhibiting an axial clearance (47) configured such that, when a pressure is exerted on an off-centre action zone (102a) by the thumb of an operator, the axial clearance (47) is taken up in this zone (102a), while the connection (42) retains a reaction zone (102b), arranged diametrically opposite the action zone (102a), axially and locally relative to the lower part (24a).