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公开(公告)号：EP4105337A1
公开(公告)日：2022-12-21
申请号：EP22175488.0
申请日：2015-09-09
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute Of Technology
发明人： REGEV, Aviv , MACOSKO, Evan Zane , MCCARROLL, Steven Andrew , SHALEK, Alexander K , BASU, Anindita , FORD, Christopher B , PARK, Hongkun , WEITZ, David A
摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
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2.发明公开A DROPLET-BASED METHOD AND APPARATUS FOR COMPOSITE SINGLE-CELL NUCLEIC ACID ANALYSIS 审中-公开基于液滴法的复合单细胞核酸分析方法及装置
公开(公告)号：EP3191605A1
公开(公告)日：2017-07-19
申请号：EP15767655.2
申请日：2015-09-09
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： REGEV, Aviv , MACOSKO, Evan, Zane , MCCARROLL, Steven, Andrew , SHALEK, Alexander, K. , BASU, Anindita , FORD, Christopher, B. , PARK, Hongkun , WEITZ, David, A.
CPC分类号： C12Q1/6809 , C12N15/1096 , C12Q1/6834 , C12Q1/6869 , G06K19/06 , C12Q2521/107 , C12Q2525/15 , C12Q2525/155 , C12Q2525/161 , C12Q2525/173 , C12Q2563/149 , C12Q2563/159 , C12Q2565/629 , C12Q2563/179
摘要： The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
摘要翻译： 本发明总体上涉及分子条形码和基于乳液的微流体的组合，以高通量方式分离，裂解，条形码并从各个细胞制备核酸。
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3.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T细胞平衡基因表达，物质组合物及其使用方法
公开(公告)号：EP3262193A2
公开(公告)日：2018-01-03
申请号：EP16714607.5
申请日：2016-02-26
申请人： The Broad Institute Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc. , The Regents of the University of California
发明人： REGEV, Aviv , KUCHROO, Vijay, K. , GAUBLOMME, Jellert , LEE, Youjin , WANG, Chao , YOSEF, Nir , PARK, Hongkun , KAMINSKI, James
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , G01N33/5023
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：EP3110971B1
公开(公告)日：2019-05-08
申请号：EP15709048.1
申请日：2015-02-26
申请人： The Broad Institute Inc. , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir , PARK, Hongkun
IPC分类号： C12Q1/6883 , C07K16/28 , G01N33/68
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公开(公告)号：EP3368221A1
公开(公告)日：2018-09-05
申请号：EP16861016.0
申请日：2016-10-28
申请人： The Broad Institute Inc. , Massachusetts Institute Of Technology , President and Fellows of Harvard College , Dana-Farber Cancer Institute, Inc.
发明人： FORD, Christopher B. , WEITZ, David, A. , BASU, Anindita , REGEV, Aviv , ROTEM, Asaf , STRUHL, Kevin
CPC分类号： B01L3/502715 , B01L3/0241 , B01L3/502746 , B01L2200/027 , B01L2200/10 , B01L2300/08 , B01L2300/0864 , B01L2300/0867 , B01L2400/086 , C12M23/12 , C12M23/16 , G01N33/5011 , G01N33/502
摘要： The present invention generally relates to a controlled fluidic device to develop spatially complex environments to enhance the rate of evolution in cell populations. The method further provides an enhanced understanding in the emergence, for example, drug resistance during cancer chemotherapy.
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6.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T-ZELLEN-BALANCE-GENEXPRESSSION，MATERIALZUSAMMENSETZUNGEN UND VERFAHREN ZUR VERWENDUNG DAVON
公开(公告)号：EP3110971A2
公开(公告)日：2017-01-04
申请号：EP15709048.1
申请日：2015-02-26
申请人： The Broad Institute Inc. , The Brigham and Women's Hospital, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir , PARK, Hongkun
IPC分类号： C12Q1/68
CPC分类号： G01N33/6863 , C07K16/2866 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/75 , C07K2317/76 , C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
摘要翻译： 本发明一般涉及用于鉴定调节，控制或以其它方式影响T细胞平衡的调节网络的组合物和方法，例如Th17细胞分化，维持和/或功能，以及用于利用调节网络的组合物和方法， 控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡。 本发明还涉及鉴定和利用调节，控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡的靶基因和/或靶基因产物。
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7.发明公开DENDRITIC CELL RESPONSE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开反应树突状细胞，燃料组合物以及它们的用途方法基因表达
公开(公告)号：EP2971116A1
公开(公告)日：2016-01-20
申请号：EP14762551.1
申请日：2014-03-17
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , Massachusetts Institute of Technology
IPC分类号： C12Q1/68 , G01N33/53 , C12Q1/02 , A61K39/395
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/5047 , G01N33/6893 , G01N2800/24
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences dendritic cell (DC) response(s), for example, dendritic cell maturation, dendritic cell antiviral response(s) and/or dendritic cell inflammatory response(s), as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences dendritic cell response(s) in a variety of therapeutic and/or diagnostic indications.
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8.发明公开T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开T-电芯平衡基因表达，材料组成和及其使用方法
公开(公告)号：EP2961849A2
公开(公告)日：2016-01-06
申请号：EP14715725.9
申请日：2014-02-27
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , The Brigham and Women's Hospital, Inc. , Massachusetts Institute of Technology
发明人： REGEV, Aviv , KUCHROO, Vijay , PARK, Hongkun , YOSEF, Nir , SHALEK, Alexander, K. , GAUBLOMME, Jellert , JOLLER, Nicole C. , WU, Chuan , ANDERSON, Ana, Carrizosa
IPC分类号： C12Q1/68 , A61K39/39 , C12N5/0783
CPC分类号： C12N5/0636 , A61K31/12 , A61K31/198 , A61K31/37 , A61K31/4745 , A61K31/66 , A61K31/661 , A61K31/7076 , A61K31/7088 , A61K31/739 , A61K33/00 , A61K33/06 , A61K33/24 , A61K38/1767 , A61K38/1866 , A61K38/191 , A61K38/363 , A61K38/4866 , A61K48/00 , C07K16/28 , C07K2317/76 , C12N5/0637 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12N2501/15 , C12N2501/2301 , C12N2501/2306 , C12N2501/2323 , C12N2501/25 , C12N2501/90 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y304/21069 , G01N33/56972 , G01N2570/00 , G01N2800/56
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
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公开(公告)号：EP4200446A1
公开(公告)日：2023-06-28
申请号：EP21862447.6
申请日：2021-08-22
申请人： The Broad Institute, Inc. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , The General Hospital Corporation
发明人： REGEV, Aviv , HWANG, William , JAGADEESH, Karthik , GUO, Jimmy , JACKS, Tyler , HOFFMAN, Hannah
IPC分类号： C12Q1/6886
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10.发明公开
公开(公告)号：EP3638218A1
公开(公告)日：2020-04-22
申请号：EP18818420.4
申请日：2018-06-14
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