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公开(公告)号：EP3693006A1
公开(公告)日：2020-08-12
申请号：EP18864669.9
申请日：2018-10-04
申请人： Toko Yakuhin Kogyo Co., Ltd. , Tokyo Metropolitan Institute of Medical Science , Japan as Represented by Director-General of National Institute of Infectious Diseases , Kagoshima University , National University Corporation Ehime University
发明人： KAMISHITA, Taizou , MIYAZAKI, Takashi , KOHARA, Michinori , SANADA, Takahiro , HIASA, Yoichi , YOSHIDA, Osamu , KOHARA, Kyoko , HASEGAWA, Hideki
摘要： The present invention relates to a hepatitis B vaccine composition for spray-administration to nasal mucosa for preventing and treating hepatitis B, which comprises hepatitis B antigen and carboxy vinyl polymer.
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2.发明公开
公开(公告)号：EP4130021A1
公开(公告)日：2023-02-08
申请号：EP21774659.3
申请日：2021-03-22
申请人： Toko Yakuhin Kogyo Co., Ltd. , Japan as Represented by Director-General of National Institute of Infectious Diseases
IPC分类号： C07K1/00 , A61K38/02 , A61K38/06 , A61K39/395 , A61P31/16 , C07K1/14 , C07K16/00 , C07K16/28 , C07K16/46 , C12N15/12 , C12N15/62
摘要： Provided is a method for producing trimeric and tetrameric IgA antibodies, the method including mixing dimeric IgA antibodies and monomeric IgA antibodies.
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公开(公告)号：EP4454661A1
公开(公告)日：2024-10-30
申请号：EP22911237.0
申请日：2022-12-20
申请人： Toko Yakuhin Kogyo Co., Ltd. , Japan as Represented by Director-General of National Institute of Infectious Diseases
IPC分类号： A61K39/39 , A61K39/145 , A61K39/215 , A61K47/02 , A61K47/04 , A61K47/18 , A61P31/14 , A61P31/16
摘要： The present disclosure provides a vaccine adjuvant agent comprising a polymer in which a constitutional unit is derived from acrylic acid, wherein the polymer has a carboxyl group content of 60.0 to 62.5 % by mass.
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4.发明公开
公开(公告)号：EP2413961A1
公开(公告)日：2012-02-08
申请号：EP10714104.6
申请日：2010-03-31
申请人： Japan As Represented By Director-General Of National Institute Of Infectious Diseases , THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY , Toko Yakuhin Kogyo Kabushiki Kaisha
IPC分类号： A61K39/145 , A61K39/39 , C07K14/11
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/525 , A61K2039/5254 , A61K2039/543 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/6093 , C12N2760/16134
摘要： The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.
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公开(公告)号：EP2939692A1
公开(公告)日：2015-11-04
申请号：EP13867863.6
申请日：2013-10-23
申请人： Japan as Represented by Director-General of National Institute of Infectious Diseases , Toko Yakuhin Kogyo Kabushiki Kaisha
IPC分类号： A61K39/145 , A61K9/06 , A61K9/72 , A61K47/32 , A61P31/16
CPC分类号： A61K39/145 , A61K9/0043 , A61K9/06 , A61K39/12 , A61K47/32 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , C12N7/00 , C12N2760/16121 , C12N2760/16134 , C12N2760/16234
摘要： The invention relates to an influenza vaccine composition for spray-administration to nasal mucosa, which comprises an inactivated whole influenza virion and a gel base material comprising carboxy vinyl polymer, which is characterized by not comprising an adjuvant.
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公开(公告)号：EP2939692B1
公开(公告)日：2019-04-24
申请号：EP13867863.6
申请日：2013-10-23
申请人： Japan as Represented by Director-General of National Institute of Infectious Diseases , Toko Yakuhin Kogyo Kabushiki Kaisha
IPC分类号： A61K39/145 , A61K9/06 , A61K9/72 , A61K47/32 , A61P31/16
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公开(公告)号：EP3804752A1
公开(公告)日：2021-04-14
申请号：EP19816086.3
申请日：2019-06-04
申请人： Toko Yakuhin Kogyo Co., Ltd. , National University Corporation Ehime University , Centro De Ingeniería Genética Y Biotecnología
发明人： KAMISHITA, Taizou , MIYAZAKI, Takashi , HIASA, Yoichi , SHEIKH MOHAMMAD, Fazle Akbar , YOSHIDA, Osamu , AGUILAR RUBIDO, Julio Cesar , GUILLEN NIETO, Gerardo Enrique , PENTON ARIAS, Eduardo
摘要： The present invention relates to a rhinovaccination system for preventing and treating hepatitis B, comprising a hepatitis B vaccine composition for administration to nasal mucosa in combination with a medical nozzle device.
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公开(公告)号：EP3804729A1
公开(公告)日：2021-04-14
申请号：EP19814700.1
申请日：2019-06-07
IPC分类号： A61K31/58 , A61K9/08 , A61K9/12 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/32 , A61K47/34 , A61P11/02 , A61P29/00 , A61P37/08
摘要： The present invention relates to a pharmaceutical composition comprising fluticasone furoate and carboxy vinyl polymer.
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9.发明公开
公开(公告)号：EP4442281A1
公开(公告)日：2024-10-09
申请号：EP22901414.7
申请日：2022-12-01
IPC分类号： A61K47/32
CPC分类号： Y02A50/30 , A61K47/10 , A61K47/32 , A61K48/00 , A61P31/06 , A61K39/29 , A61P31/04 , A61K39/09 , A61P31/12 , A61K39/098 , A61K39/12 , A61K35/76 , A61K39/235 , A61K39/215 , A61K47/02 , A61P31/18 , A61P31/16 , A61P31/14 , A61K9/08 , A61K39/02 , A61K39/25 , A61P31/22 , A61K39/20 , A61K39/00 , A61K39/245 , A61K39/102 , A61K39/145 , A61K47/18
摘要： The present invention relates to a formulation base prepared by adding polyethylene glycol to crosslinked polyacrylic acid, and a formulation for spraying nasal vaccine comprising an antigen, which have optimized spray pattern targeting simultaneously both of nasal mucosa and nasopharynx.
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公开(公告)号：EP4382153A1
公开(公告)日：2024-06-12
申请号：EP22853016.8
申请日：2022-08-01
IPC分类号： A61M11/00
CPC分类号： A61M11/00
摘要： A nasal spray/injection nozzle according to one embodiment of the present invention comprises a pair of sub-nozzles. Each of the sub-nozzles has an ejection hole formed at the leading end. The sub-nozzles are coupled to each other through a joining section. The separation distance between the axis of one of the sub-nozzles and the axis of the other sub-nozzle increases from the joining section toward the respective leading ends.
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