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11 条记录 (耗时 0.022 秒)

    BIOSENSING METHOD USING COATED MAGNETIC MICROPARTICLES AND BIOSENSING DEVICE TO BE USED IN THE METHOD
    7.
    发明公开
    BIOSENSING METHOD USING COATED MAGNETIC MICROPARTICLES AND BIOSENSING DEVICE TO BE USED IN THE METHOD 有权
    生物传感方法使用涂磁微颗粒中的过程;适用生物传感器件

    公开(公告)号：EP2246702A1

    公开(公告)日：2010-11-03

    申请号：EP08857449.6

    申请日：2008-12-01

    申请人： Tokyo Institute of Technology

    发明人： HANDA, Hiroshi ,  ABE, Masanori ,  HATAKEYAMA, Mamoru ,  SAKAMOTO, Satoshi ,  NISHIO, Kosuke ,  MOCHIZUKI, Yusuke

    IPC分类号： G01N33/543 ,  G01N5/02 ,  G01N21/27 ,  G01N33/553

    CPC分类号： G01N33/54333 ,  G01N21/553

    摘要： An object of the present invention is to provide a novel biosensing method as the novel application development of the magnetic particles in the biosensing. In an affinity reaction of biosensing, ligands are immobilized to magnetic fine particles and the magnetic fine particles are forced to reaction fields of the affinity reaction by magnetic guiding so as to bring the affinity reaction, which is the velocity controlling factor in the sensing, to high rates. According to the present invention, coated magnetic fine particles with having both of the high dispersion performance and high magnetic responsibility as the above described magnetic fine particles and the affinity reaction occurs quickly and in high density such that the present invention makes it possible to obtain relatively large signals within significantly short time duration when compared to the conventional art.

    摘要翻译： 本发明的一个目的是提供一种新颖的生物传感方法作为生物感测磁性粒子的新颖的应用开发。 在生物传感中的亲和反应中，配体固定到磁性微粒和磁性微粒被强制由磁性引导所述亲和反应的反应场，以便使所述亲和反应中，所有这一切是速度感测控制因素，以 高利率。 。根据本发明，包被的磁性微粒与具有两个高分散性能和高磁响应性与上述磁性细颗粒和亲和反应的发生快速和高密度检测所做的本发明使得有可能获得相对 值得注意的是短的持续时间内大信号。当相比于常规技术。

    PHYSICAL AMOUNT DETECTION DEVICE
    9.
    发明公开
    PHYSICAL AMOUNT DETECTION DEVICE 审中-公开
    DETEKTIONSEINRICHTUNG PHYSISCHER MENGEN

    公开(公告)号：EP2211194A1

    公开(公告)日：2010-07-28

    申请号：EP08845650.4

    申请日：2008-10-29

    申请人： Tokyo Institute of Technology

    发明人： UEDA, Tomoaki ,  ABE, Masanori ,  NAKAGAWA, Takashi ,  TADA, Masaru ,  MIZUMOTO, Tetsuya ,  HANDA, Hiroshi ,  SANDHU, Adarsh ,  ARAKI, Kiyomichi

    IPC分类号： G01R33/07

    CPC分类号： G01R33/07

    摘要： Provided is a highly sensitive sensor system that can improve the S/N ratio by use of an electronic circuit without complicating the sensor body or degrading temporal resolution. A broad spectrum sensor element outputs an electric signal corresponding to a detected physical quantity, the sensor driven by multiplying a carrier signal by m-sequence code. The spread spectrum signal, after phase adjustment, is used to demodulate the sensor output signal, which corresponds to the broad spread spectrum of the physical quantity. The electrical noise generated in the sensor is a broad spread spectrum and is suppressed by low-pass filtering so as to improve the S/N ratio.

    摘要翻译： 提供了一种高灵敏度的传感器系统，其可以通过使用电子电路来提高S / N比，而不会使传感器体复杂化或降低时间分辨率。 宽频谱传感器元件输出对应于检测到的物理量的电信号，该传感器通过乘以载波信号由m序列码驱动。 相位调整后的扩频信号用于解调对应于物理量的广泛扩频的传感器输出信号。 在传感器中产生的电噪声是广泛的扩频，并通过低通滤波来抑制，以提高S / N比。

    PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES
    10.
    发明公开
    PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES 有权
    VERFAHREN ZUR HERSTELLUNG VONOBERFLÄCHENBESCHICHTETENANORGANISCHEN TEILCHEN

    公开(公告)号：EP2184262A1

    公开(公告)日：2010-05-12

    申请号：EP08791605.2

    申请日：2008-07-25

    申请人： Tokyo Institute of Technology

    发明人： HANDA, Hiroshi ,  HATAKEYAMA, Mamoru ,  ABE, Masanori ,  SAKAMOTO, Satoshi ,  MASAIKE, Yuka ,  NISHIO, Kosuke ,  KITA, Yoshinori ,  KISHI, Hiroshi

    IPC分类号： C01G49/00 ,  A61K49/00 ,  B22F1/02 ,  H01F1/20 ,  H01F1/34 ,  H01F1/36

    CPC分类号： H01F1/0045 ,  A61K41/0052 ,  A61K49/183 ,  A61K49/1833 ,  A61K49/1836 ,  A61K49/1851 ,  A61K49/1854 ,  B22F1/0022 ,  B22F1/0062 ,  B82Y25/00 ,  B82Y30/00 ,  C01G49/00 ,  C01P2006/42 ,  C09C1/24 ,  C09C3/08 ,  C09C3/10 ,  C09C3/12 ,  G01N33/53 ,  G01N33/54393 ,  H01F1/0054

    摘要： Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.

    摘要翻译： 已经通过在有机溶剂中合成来制备具有均匀粒径和精确控制的粒径的纳米尺寸的无机颗粒，但这些纳米尺寸的无机颗粒由于吸附长链脂肪而被阻碍分散在极性溶剂中 酸在颗粒的表面上。 此外，通过代替长链脂肪酸涂层，难以形成分散在极性溶剂中的纳米级无机颗粒。 根据本发明，分散在极性溶剂中的各种表面涂覆的无机颗粒可以通过向包含分散在其中的含脂肪酸涂覆的无机颗粒的非极性溶剂添加例如硫代酸的临时涂层物质，由脂肪酸包覆的无机颗粒制备，以代替 通过临时涂布物质的脂肪酸涂层，将涂覆有临时涂层物质的无机颗粒分散在极性溶剂中，然后将分散在极性溶剂（例如柠檬酸）中的涂覆物质加入到所得分散体中以代替临时涂层 通过可分散在极性溶剂中的涂层物质覆盖无机颗粒的物质外套。