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公开(公告)号:EP1929298A4
公开(公告)日:2008-11-05
申请号:EP06759596
申请日:2006-05-11
申请人: UNIV MARYLAND
发明人: FASANO ALESSIO
IPC分类号: G01N33/543 , G01N33/00 , G01N33/53 , G01N33/541
CPC分类号: G01N33/566 , G01N33/564 , G01N2800/062
摘要: The present invention provides materials and methods to assess the efficacy of a treatment. In some embodiments, the present invention provides a method of assessing the efficacy of a treatment for celiac disease by measuring the serum zonulin level of a subject having received the treatment.
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公开(公告)号:EP1007553A4
公开(公告)日:2004-09-22
申请号:EP98904957
申请日:1998-02-18
申请人: UNIV MARYLAND
发明人: FASANO ALESSIO
IPC分类号: G01N33/50 , C07K14/28 , C07K14/705 , G01N33/15 , G01N33/566 , G01N33/22
CPC分类号: C07K14/28 , C07K14/705 , Y10S435/909 , Y10S530/825
摘要: Receptors for the zonula occludens toxin of Vibrio cholera, as well as methods involving the use of the same to screen for an agonist or antagonist of the toxin.
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公开(公告)号:EP1102596A4
公开(公告)日:2002-08-14
申请号:EP99940809
申请日:1999-07-28
申请人: UNIV MARYLAND
发明人: FASANO ALESSIO
IPC分类号: C12N15/09 , A61K38/00 , A61K38/08 , A61K38/16 , A61K38/17 , A61K39/395 , A61P1/00 , A61P1/04 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07K7/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/47 , C12N15/15
CPC分类号: C07K7/06 , A61K38/00 , C07K7/08 , C07K14/4705 , C07K14/4716
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4.SUBSTANTIALLY PURE ZONULIN, A PHYSIOLOGICAL MODULATOR OF MAMMALIAN TIGHT JUNCTIONS 失效
标题翻译: 基本纯净的桑IN苷作为奇迹中“紧密连接”的生理调节剂公开(公告)号:EP0982988A4
公开(公告)日:2000-04-05
申请号:EP98919778
申请日:1998-04-28
申请人: UNIV MARYLAND
发明人: FASANO ALESSIO
IPC分类号: C12N15/09 , A61K31/05 , A61K31/135 , A61K31/137 , A61K31/167 , A61K31/221 , A61K31/427 , A61K31/43 , A61K31/431 , A61K31/4468 , A61K31/472 , A61K31/475 , A61K31/485 , A61K31/5377 , A61K31/545 , A61K31/5517 , A61K31/568 , A61K31/704 , A61K31/7076 , A61K38/00 , A61K38/16 , A61K38/21 , A61K38/28 , A61K45/00 , A61K47/42 , A61K47/48 , C07K14/47 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号: C07K14/4716 , A61K38/28 , A61K47/62 , C07K14/4705 , Y10S530/839 , Y10S530/844
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公开(公告)号:EP1648917A4
公开(公告)日:2008-11-12
申请号:EP04778327
申请日:2004-07-15
申请人: UNIV MARYLAND
发明人: FASANO ALESSIO , VOGEL STEFANIE N
IPC分类号: C07K5/00 , A61K38/08 , A61K38/10 , B65H23/188 , C07K20060101 , C07K14/28
CPC分类号: C07K14/28 , A61K38/00 , C07K7/06 , G01N33/564
摘要: Agonist polypeptide of a receptor protein has been identified. The agonist can be used to facilitate drug and antigen absorption. Suitable routes of administration include oral, nasal, transdermal, and intravenous. Pharmaceutical formulations may comprise a therapeutic agent or an immunogenic agent in combination with the agonist polypeptide.
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公开(公告)号:EP1841451A4
公开(公告)日:2008-11-05
申请号:EP06718341
申请日:2006-01-13
发明人: DE MAGISTRIS MARIA , FASANO ALESSIO
IPC分类号: A61K39/39 , A61K39/116
CPC分类号: A61K39/39 , A61K39/00 , A61K2039/541 , A61K2039/543 , A61K2039/55544
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公开(公告)号:EP0734451A4
公开(公告)日:1997-11-26
申请号:EP95903130
申请日:1994-12-01
申请人: UNIV MARYLAND
IPC分类号: C12N15/09 , A61K38/00 , A61K39/112 , A61K39/395 , C07H21/04 , C07K14/25 , C07K16/12 , C12N1/21 , C12P21/02 , C12P21/04 , C12R1/01 , A01N63/00 , C07H17/00 , C07H19/00 , C07H21/00 , C07K1/00 , C07K2/00 , C07K4/00 , C07K14/00 , C07K16/00
CPC分类号: C07K16/1203 , A61K38/00 , C07K14/25 , C12R1/01 , Y10S530/825
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8.METHOD OF USING ZOT OR ZONULIN TO INHIBIT LYMPHOCYTE PROLIFERATION IN AN ANTIGEN-SPECIFIC MANNER 有权
标题翻译: 程序支持或ZOT连蛋白素抑制淋巴细胞增殖活性的抗原特异性的方式使用公开(公告)号:EP1113813A4
公开(公告)日:2002-05-29
申请号:EP99969032
申请日:1999-09-09
申请人: UNIV MARYLAND
IPC分类号: A61K39/106 , A61K38/16 , A61K38/17 , A61P37/06 , A61K39/00
CPC分类号: A61K38/164 , A61K38/1709
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公开(公告)号:EP1028715A4
公开(公告)日:2001-10-10
申请号:EP98902381
申请日:1998-01-09
申请人: UNIV MARYLAND , CHIRON SPA
IPC分类号: C12N15/09 , A61K9/00 , A61K9/72 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/42 , C07K14/245 , C07K14/28 , A61K38/28 , C07K14/05 , C07K14/195 , C07K14/62
CPC分类号: C07K14/28 , A61K9/0043 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61K47/42 , C07K14/245 , C07K2319/00
摘要: A nasal dosage composition for nasal delivery comprising (A) a therapeutic agent; and (B) zonula occludens toxin, as well as a method for the use of the same.
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10.ORAL DOSAGE COMPOSITION FOR INTESTINAL DELIVERY AND METHOD OF USE OF THE SAME 失效
标题翻译: FOR USE肠口服给药剂量和方法公开(公告)号:EP0828481A4
公开(公告)日:1999-06-09
申请号:EP96914626
申请日:1996-05-16
申请人: UNIV MARYLAND
发明人: FASANO ALESSIO
IPC分类号: A61K9/00 , A61K31/135 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/28 , A61K39/395 , A61K47/42 , A61P3/10 , C07K14/28 , C07K14/705 , A61K9/20
CPC分类号: C07K14/705 , A61K38/00 , A61K47/42 , C07K14/28 , C07K2319/00 , Y10S514/837 , Y10S514/866
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