公开(公告)号：EP1575524A4

公开(公告)日：2008-11-05

申请号：EP03713393

申请日：2003-02-07

申请人： UNIV SOUTH FLORIDA ,  UNIV CHILE

发明人： CAVIEDES PABLO ,  CAVIEDES RAUL ,  FREEMAN THOMAS B ,  SANBERG PAUL R ,  CAMERON DON F

IPC分类号： C12Q1/02 ,  A61K35/12 ,  A61K35/26 ,  A61K45/00 ,  A61P1/16 ,  A61P3/10 ,  A61P5/06 ,  A61P9/10 ,  A61P17/02 ,  A61P19/02 ,  A61P21/02 ,  A61P25/00 ,  A61P25/04 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/475 ,  C12N5/00 ,  C12N5/06 ,  A01N1/00 ,  A01N1/02 ,  A01N37/18 ,  A61K38/00 ,  A61K39/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  G01N33/53

CPC分类号： A61K35/26 ,  C12N5/0018 ,  C12N2500/84 ,  C12N2502/078 ,  C12N2502/30 ,  C12N2503/02

摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferation cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferation cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

公开(公告)号：EP0814819A4

公开(公告)日：2001-05-02

申请号：EP96908759

申请日：1996-03-12

申请人： UNIV SOUTH FLORIDA

发明人： SANBERG PAUL R ,  CAMERON DON F ,  BORLONGAN CESARIO V ,  HELLER RICHARD

IPC分类号： A61K35/12 ,  A61K35/30 ,  A61K35/48 ,  C12N5/071 ,  A61K35/00 ,  A01N63/00 ,  C12N5/06

CPC分类号： C12N5/0683 ,  A61K35/12 ,  A61K35/30 ,  A61K35/48 ,  A61K2035/122 ,  C12N5/0618 ,  C12N2502/246

摘要： A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.

公开(公告)号：EP1006801A4

公开(公告)日：2001-05-02

申请号：EP96908758

申请日：1996-03-12

申请人： UNIV SOUTH FLORIDA

发明人： SANBERG PAUL R ,  CAMERON DON F ,  BORLONGAN CESARIO V

IPC分类号： C12N5/06 ,  A01N63/00 ,  A61K35/00 ,  A61K35/48 ,  A61P25/00 ,  C12N5/00

CPC分类号： A61K35/48

摘要： A method of generating in situ trophic factor production by transplanting Sertoli cells into a tissue in need of trophic factors of a mammal, the cells creating trophic factors in situ.