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公开(公告)号：EP2822930B1
公开(公告)日：2016-01-20
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28 , A61K31/506 , C07C255/47 , C07C313/06 , C07D405/06 , C07C229/50 , C07C331/14
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
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公开(公告)号：EP2406240B1
公开(公告)日：2015-12-23
申请号：EP10708684.5
申请日：2010-03-12
发明人： CACATIAN, Salvacion , CLAREMON, David, A. , DILLARD, Lawrence, W. , FUCHS, Klaus , HEINE, Niklas , JIA, Lanqi , LEFTHERIS, Katerina , MCKEEVER, Brian , MORALES-RAMOS, Angel , SINGH, Suresh , VENKATRAMAN, Shankar , WU, Guosheng , WU, Zhongren , XU, Zhenrong , YUAN, Jing , ZHENG, Yajun
IPC分类号： C07D233/46 , C07D235/02
CPC分类号： C07D271/12 , C07D233/46 , C07D235/02 , C07D239/70 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
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公开(公告)号：EP2888236A1
公开(公告)日：2015-07-01
申请号：EP13760166.2
申请日：2013-08-26
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , GROSS, Ulrike , HEINE, Niklas , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , SINGH, Suresh, B. , SAUER, Achim , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D401/06 , C07D403/04 , A61K31/4184 , A61P25/28
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K31/506 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/59 , C07C313/06 , C07C331/26 , C07C2603/94 , C07C2603/97 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β- secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环酰基胍和它们作为β-分泌酶（BACE1）活性抑制剂的用途，含有该化合物的药物组合物，以及使用它们作为治疗剂治疗神经变性疾病，以认知衰退为特征的疾病的方法 ，认知障碍，痴呆和特征在于产生β-淀粉样蛋白聚集体的疾病。
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公开(公告)号：EP2822930A1
公开(公告)日：2015-01-14
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环酰基胍及其作为β-分泌酶（BACE1）活性抑制剂的用途，含有该化合物的药物组合物，以及使用该化合物作为治疗剂治疗神经变性疾病，以认知衰退为特征的疾病的方法 ，认知障碍，痴呆和特征在于产生β-淀粉样蛋白聚集体的疾病。
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公开(公告)号：EP2406240A2
公开(公告)日：2012-01-18
申请号：EP10708684.5
申请日：2010-03-12
发明人： CACATIAN, Salvacion , CLAREMON, David, A. , DILLARD, Lawrence, W. , FUCHS, Klaus , HEINE, Niklas , JIA, Lanqi , LEFTHERIS, Katerina , MCKEEVER, Brian , MORALES-RAMOS, Angel , SINGH, Suresh , VENKATRAMAN, Shankar , WU, Guosheng , WU, Zhongren , XU, Zhenrong , YUAN, Jing , ZHENG, Yajun
IPC分类号： C07D277/60 , C07D271/12 , C07D235/02 , C07D239/70 , C07D491/10 , C07D487/10 , C07D403/06 , C07D405/12 , C07D498/10 , A61K31/4245 , A61K31/4184 , A61K31/4188 , A61K31/517 , A61K31/519 , A61K31/428
CPC分类号： C07D271/12 , C07D233/46 , C07D235/02 , C07D239/70 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
摘要： The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.
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公开(公告)号：EP2825542A1
公开(公告)日：2015-01-21
申请号：EP13712103.4
申请日：2013-03-14
发明人： DONG, Chengguo , FAN, Yi , LEFTHERIS, Katerina , LOTESTA, Stephen , SINGH, Suresh, B. , TICE, Colin , ZHAO, Wei , ZHENG, Yajun , ZHUANG, Linghang
IPC分类号： C07D487/04 , A61K31/5025 , A61P3/06
CPC分类号： A61K31/506 , A61K31/4985 , C07D487/04 , C07F7/1804
摘要： Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
摘要翻译： 本文提供了作为肝X受体调节剂的新化合物及其药学上可接受的盐。 还提供了包含本发明化合物和载体的组合物。 另外，进一步描述了本文中化合物的用途以及用于治疗与肝X受体相关的疾病或病症的方法。
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公开(公告)号：EP3512850A1
公开(公告)日：2019-07-24
申请号：EP17772585.0
申请日：2017-09-15
发明人： CACATIAN, Salvacion , CLAREMON, David A. , DONG, Chengguo , FAN, Yi , JIA, Lanqi , LOTESTA, Stephen D. , SINGH, Suresh B. , VENKATRAMAN, Shankar , YUAN, Jing , ZHENG, Yajun , ZHUANG, Linghang
IPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , C07D487/04
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公开(公告)号：EP3207043B1
公开(公告)日：2018-12-12
申请号：EP15785013.2
申请日：2015-10-14
发明人： CLAREMON, David, A. , DILLARD, Lawrence, Wayne , DONG, Chengguo , FAN, Yi , JIA, Lanqi , LOTESTA, Stephen, D. , MARCUS, Andrew , SINGH, Suresh, B. , TICE, Colin, M. , YUAN, Jing , ZHAO, Wei , ZHENG, Yajun , ZHUANG, Linghang
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P29/00 , A61P37/02
CPC分类号： C07D471/04
摘要： pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.
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公开(公告)号：EP2900650A1
公开(公告)日：2015-08-05
申请号：EP13771747.6
申请日：2013-09-25
发明人： VENKATRAMAN, Shankar , YUAN, Jing , ZHENG, Yajun
IPC分类号： C07D401/04 , C07D235/02 , A61K31/4184 , A61K31/4439 , A61P25/28
CPC分类号： C07D401/12 , C07D235/02 , C07D401/04
摘要： The present invention relates to spirocyclic indane imidazole 4-amines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
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公开(公告)号：EP2539322A1
公开(公告)日：2013-01-02
申请号：EP11706719.9
申请日：2011-02-23
发明人： DILLARD. Lawrence W. , YUAN, Jing , LEFTHERIS. Katerina , VENKATRAMAN, Shankar , WU, Guosheng , JIA, Lanqi , XU, Zhenrong , CACATIAN, Salvacion , MORALES-RAMOS, Angel , SINGH, Suresh , ZHENG, Yajun
IPC分类号： C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D513/04 , A61K31/40 , A61P25/28 , A61P27/06
CPC分类号： C07D513/04 , C07D209/54 , C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D498/04
摘要： The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
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