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公开(公告)号：EP2822930B1
公开(公告)日：2016-01-20
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28 , A61K31/506 , C07C255/47 , C07C313/06 , C07D405/06 , C07C229/50 , C07C331/14
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
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公开(公告)号：EP2539322A1
公开(公告)日：2013-01-02
申请号：EP11706719.9
申请日：2011-02-23
发明人： DILLARD. Lawrence W. , YUAN, Jing , LEFTHERIS. Katerina , VENKATRAMAN, Shankar , WU, Guosheng , JIA, Lanqi , XU, Zhenrong , CACATIAN, Salvacion , MORALES-RAMOS, Angel , SINGH, Suresh , ZHENG, Yajun
IPC分类号： C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D513/04 , A61K31/40 , A61P25/28 , A61P27/06
CPC分类号： C07D513/04 , C07D209/54 , C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D498/04
摘要： The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
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3.发明公开PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开精选ALS CD73-INHIBITOREN ZUR BEHANDLUNG VON KREBS
公开(公告)号：EP3134411A1
公开(公告)日：2017-03-01
申请号：EP15722317.3
申请日：2015-04-23
发明人： CACATIAN, Salvacion , CLAREMON, David A. , JIA, Lanqi , MORALES-RAMOS, Angel , SINGH, Suresh B. , VENKATRAMAN, Shankar , XU, Zhenrong , ZHENG, Yajun
IPC分类号： C07D473/40 , C07D473/34 , C07D473/36 , C07D405/04 , C07H19/06 , C07H19/16 , A61K31/506 , A61K31/675 , A61K31/7052 , A61P33/00
CPC分类号： C07H19/16 , A61K31/517 , A61K31/675 , A61K31/7056 , A61K31/7072 , A61K31/7076 , A61K45/06 , C07D239/72 , C07D405/04 , C07D473/34 , C07D473/36 , C07D473/40 , C07F9/65128 , C07F9/65616 , C07H19/052 , C07H19/06
摘要： Provided are novel compounds, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are inhibitors of CD73 and are useful in the treatment of cancer.
摘要翻译： 提供了新的化合物，其药学上可接受的盐及其药物组合物，其是CD73的抑制剂并且可用于治疗癌症。
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公开(公告)号：EP2822930A1
公开(公告)日：2015-01-14
申请号：EP13710937.7
申请日：2013-03-04
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , RAST, Georg , REEVES, Jonathan , SINGH, Suresh, B. , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D403/06 , C07D407/06 , C07C49/323 , A61K31/4184 , A61P25/28
CPC分类号： A61K31/506 , A61K31/4184 , C07C49/697 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/47 , C07C313/06 , C07C331/14 , C07D235/02 , C07D403/06 , C07D405/06 , C07D407/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环酰基胍及其作为β-分泌酶（BACE1）活性抑制剂的用途，含有该化合物的药物组合物，以及使用该化合物作为治疗剂治疗神经变性疾病，以认知衰退为特征的疾病的方法 ，认知障碍，痴呆和特征在于产生β-淀粉样蛋白聚集体的疾病。
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公开(公告)号：EP2406240A2
公开(公告)日：2012-01-18
申请号：EP10708684.5
申请日：2010-03-12
发明人： CACATIAN, Salvacion , CLAREMON, David, A. , DILLARD, Lawrence, W. , FUCHS, Klaus , HEINE, Niklas , JIA, Lanqi , LEFTHERIS, Katerina , MCKEEVER, Brian , MORALES-RAMOS, Angel , SINGH, Suresh , VENKATRAMAN, Shankar , WU, Guosheng , WU, Zhongren , XU, Zhenrong , YUAN, Jing , ZHENG, Yajun
IPC分类号： C07D277/60 , C07D271/12 , C07D235/02 , C07D239/70 , C07D491/10 , C07D487/10 , C07D403/06 , C07D405/12 , C07D498/10 , A61K31/4245 , A61K31/4184 , A61K31/4188 , A61K31/517 , A61K31/519 , A61K31/428
CPC分类号： C07D271/12 , C07D233/46 , C07D235/02 , C07D239/70 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
摘要： The present invention is directed to a compound represented by the following structural formula or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions and method of use of the compounds are also described.
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公开(公告)号：EP3468966A1
公开(公告)日：2019-04-17
申请号：EP17739383.2
申请日：2017-06-08
发明人： CACATIAN, Salvacion , CLAREMON, David, A. , DILLARD, Lawrence, Wayne , DONG, Chengguo , FAN, Yi , JIA, Lanqi , LOTESTA, Stephen, D. , MARCUS, Andrew , MORALES-RAMOS, Angel , SINGH, Suresh, B. , VENKATRAMAN, Shankar , YUAN, Jing , ZHENG, Yajun , ZHUANG, Linghang , PARENT, Stephan, D. , HOUSTON, Travis, L.
IPC分类号： C07D405/14 , C07D403/04 , C07D403/14 , C07D471/10 , C07D487/10 , C07D491/10 , A61K31/407 , A61P35/00 , A61P3/10
摘要： The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.
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公开(公告)号：EP2406240B1
公开(公告)日：2015-12-23
申请号：EP10708684.5
申请日：2010-03-12
发明人： CACATIAN, Salvacion , CLAREMON, David, A. , DILLARD, Lawrence, W. , FUCHS, Klaus , HEINE, Niklas , JIA, Lanqi , LEFTHERIS, Katerina , MCKEEVER, Brian , MORALES-RAMOS, Angel , SINGH, Suresh , VENKATRAMAN, Shankar , WU, Guosheng , WU, Zhongren , XU, Zhenrong , YUAN, Jing , ZHENG, Yajun
IPC分类号： C07D233/46 , C07D235/02
CPC分类号： C07D271/12 , C07D233/46 , C07D235/02 , C07D239/70 , C07D277/60 , C07D279/08 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/10 , C07D487/10 , C07D491/10 , C07D493/20 , C07D495/10 , C07D498/10 , C07D513/10
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公开(公告)号：EP2888236A1
公开(公告)日：2015-07-01
申请号：EP13760166.2
申请日：2013-08-26
发明人： BUKHTIYAROV, Yuri , CACATIAN, Salvacion , DILLARD, Lawrence, Wayne , DORNER-CIOSSEK, Cornelia , FUCHS, Klaus , GROSS, Ulrike , HEINE, Niklas , JIA, Lanqi , LALA, Deepak, S. , MORALES-RAMOS, Angel , SINGH, Suresh, B. , SAUER, Achim , VENKATRAMAN, Shankar , XU, Zhenrong , YUAN, Jing , ZHAO, Yi , ZHENG, Yajun
IPC分类号： C07D235/02 , C07D401/06 , C07D403/04 , A61K31/4184 , A61P25/28
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K31/506 , C07C49/747 , C07C49/755 , C07C229/50 , C07C255/59 , C07C313/06 , C07C331/26 , C07C2603/94 , C07C2603/97 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/06
摘要： The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β- secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
摘要翻译： 本发明涉及螺环酰基胍和它们作为β-分泌酶（BACE1）活性抑制剂的用途，含有该化合物的药物组合物，以及使用它们作为治疗剂治疗神经变性疾病，以认知衰退为特征的疾病的方法 ，认知障碍，痴呆和特征在于产生β-淀粉样蛋白聚集体的疾病。
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公开(公告)号：EP2539322B1
公开(公告)日：2014-01-01
申请号：EP11706719.9
申请日：2011-02-23
发明人： DILLARD, Lawrence W. , YUAN, Jing , LEFTHERIS, Katerina , VENKATRAMAN, Shankar , WU, Guosheng , JIA, Lanqi , XU, Zhenrong , CACATIAN, Salvacion , MORALES-RAMOS, Angel , SINGH, Suresh , ZHENG, Yajun
IPC分类号： C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/04 , C07D513/04 , A61K31/40 , A61P25/28 , A61P27/06
CPC分类号： C07D513/04 , C07D209/54 , C07D209/96 , C07D401/04 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/107 , C07D498/04
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