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    IMPROVED BLOOD CONTACT SURFACES USING EXTRACELLULAR MATRIX SYNTHESIZED IN VITRO
    2.
    发明公开
    IMPROVED BLOOD CONTACT SURFACES USING EXTRACELLULAR MATRIX SYNTHESIZED IN VITRO 失效
    血液接触面使用​​合成的体外细胞外基质

    公开(公告)号：EP0757563A1

    公开(公告)日：1997-02-12

    申请号：EP95917749.0

    申请日：1995-04-28

    申请人： W.L. GORE & ASSOCIATES, INC.

    发明人： BRUCHMAN, William, C. ,  BEGOVAC, Paul, C.

    IPC分类号： A61L27 ,  A61F2 ,  A61L33

    CPC分类号： A61L27/507 ,  A61F2/06 ,  Y10S623/916

    摘要： This invention is directed to improved blood contact devices such as vascular prostheses rendered substantially nonthrombogenic through addition of a preserved layer of extracellular subendothelial matrix. The preserved subendothelial matrix layer, which serves as the blood interface of the device, is analogous to the subendothelial matrix layer beneath the endothelium of native vascular surfaces. The device consists of a permanent synthetic base material, preferably porous expanded polytetrafluoroethylene, on which this biologic layer of subendothelial matrix is grown in situ. The biologic layer is produced using in vitro tissue culture methods whereby living cells synthesize and deposit extracellular matrix components, after which the cells are killed and/or removed and the subendothelial matrix layer preserved before implantation. A key aspect of this invention is that no living Cells are present in the final configuration, so that the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.

    IMPROVED BLOOD CONTACT SURFACES USING ENDOTHELIUM ON A SUBENDOTHELIAL EXTRACELLULAR MATRIX
    3.
    发明公开
    IMPROVED BLOOD CONTACT SURFACES USING ENDOTHELIUM ON A SUBENDOTHELIAL EXTRACELLULAR MATRIX 失效
    血液接触表面USING内皮上的SUBENDOTELIALEN细胞外基质

    公开(公告)号：EP0757562A1

    公开(公告)日：1997-02-12

    申请号：EP95917203.0

    申请日：1995-04-28

    申请人： W.L. GORE & ASSOCIATES, INC.

    发明人： BRUCHMAN, William, C. ,  BEGOVAC, Paul, C.

    IPC分类号： A61L27 ,  A61F2 ,  A61L33

    CPC分类号： A61L27/507 ,  A61F2/06 ,  A61L27/16 ,  C08L27/18

    摘要： This invention relates to improved blood contact devices such as vascular prostheses rendered antithrombotic through the use of recipient endothelial cells grown on an appropriate subendothelial matrix. The subendothelial matrix layer, which serves as the substratum for growing endothelial cells, may be obtained from either natural donor vessels or from in vitro tissue culture sources. This subendothelial matrix is used in situ on the donor vessel, or is grown or applied to a synthetic component, preferably porous expanded polytetrafluoroethylene. Once this subendothelial matrix is prepared, recipient endothelial cells are seeded onto this matrix substratum, which then serves as the immediate blood contact surface. The endothelial cells may be applied as an intra-operative procedure, or grown on the subendothelial matrix substratum in vitro until the cells establish a confluent monolayer. A key aspect of this invention is that living, recipient endothelial cells are grown on the appropriate subendothelial matrix substratum, thereby providing a substantially nonthrombotic blood contact surface. Furthermore, the likelihood of recipient immunological response is minimized. This invention results in vascular prostheses that are particularly useful for arterial bypass requiring a diameter of 6 mm or less.

    ELASTOMERIC LEAFLET FOR PROSTHETIC HEART VALVES
    8.
    发明公开
    ELASTOMERIC LEAFLET FOR PROSTHETIC HEART VALVES 审中-公开

    公开(公告)号：EP3679955A1

    公开(公告)日：2020-07-15

    申请号：EP20159436.3

    申请日：2014-02-18

    申请人： W.L. Gore & Associates Inc.

    发明人： BRUCHMAN, William, C. ,  WHITE, Charles, F.

    IPC分类号： A61L27/16

    摘要： A leaflet for a prosthetic valve formed of at least one layer that includes a composite material containing at least one expanded fluoropolymer membrane and an elastomer. The composite material exhibits an increase in stiffness when elongated to at least about 30% strain. The fluoropolymer may be polytetrafluoroethylene. The elasticity within the leaflets permits, among other things, the leaflets to bend with a reduced occurrence of wrinkles as the valve opens and closes. The elastic properties of the leaflet also, among other things, improve bending properties and reduce closure stresses, thereby extending the life of the leaflet.