公开(公告)号：EP2860188B1

公开(公告)日：2020-10-21

申请号：EP13804161.1

申请日：2013-06-06

申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

发明人： YUAN, Quan ,  ZHANG, Tianying ,  LUO, Wenxin ,  CHEN, Yixin ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/02 ,  C07K16/28 ,  A61K39/29

公开(公告)号：EP2982691A1

公开(公告)日：2016-02-10

申请号：EP14778269.2

申请日：2014-04-02

申请人： Xiamen University

发明人： CHEN, Yixin ,  ZHENG, Qingbing ,  LI, Rui ,  SHEN, Chenguang ,  KE, Shaojun ,  LUO, Wenxin ,  CHEN, Honglin ,  XIA, Ningshao

IPC分类号： C07K16/10 ,  C12N15/13 ,  C12N15/63 ,  C12N5/20 ,  A61K39/42 ,  A61P31/16

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2469/10

摘要： The invention relates to antibodies recognizing epitopes on HA1 domain of hemagglutinin (HA) protein of influenza virus, cell lines for producing the antibodies, and uses thereof. The antibodies according to the invention can specifically bind to HA1 domain of different HA subtypes and specifically bind to HA1 domain of hemagglutinin (HA) protein of H1 subtype (including seasonal H1N1 and 2009 pandemic H1N1) and H5 subtype of influenza viruses. Therefore, the invention also relates to vaccines or pharmaceutical compositions for preventing and/or treating infection of H1 subtype and H5 subtype influenza virus and/or a disease caused by the infection (e.g. influenza), comprising the antibodies according to the invention.

摘要翻译： 本发明涉及的抗体认识到关于流感病毒，细胞系的血凝素（HA）蛋白的HA1结构域的表位用于产生抗体，以及它们的用途。 gemäß到本发明的抗体可以特异性结合于不同HA亚型的HA1结构域和特异性结合H1亚型（包括季节性H1N1和大流行性H1N1 2009）和流感病毒H5亚型的血凝素（HA）蛋白的HA1结构域。 因此，本发明因此涉及疫苗或用于预防和/或治疗H1亚型H5和亚型A型流感病毒和/或由感染（E. G.流感）引起的疾病的感染的药物组合物，包含gemäß到本发明的抗体。

公开(公告)号：EP3699186A1

公开(公告)日：2020-08-26

申请号：EP18869363.4

申请日：2018-10-10

申请人： Xiamen University

发明人： CHEN, Yixin ,  SHEN, Chenguang ,  CHEN, Junyu ,  ZHANG, Mengya ,  ZHANG, Limin ,  XIA, Ningshao

IPC分类号： C07K14/11 ,  C12N15/44 ,  C12N15/09 ,  C12N7/00 ,  A61K39/145 ,  A61P31/16

摘要： The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.

公开(公告)号：EP2982691B1

公开(公告)日：2020-05-06

申请号：EP14778269.2

申请日：2014-04-02

申请人： Xiamen University

发明人： CHEN, Yixin ,  ZHENG, Qingbing ,  LI, Rui ,  SHEN, Chenguang ,  KE, Shaojun ,  LUO, Wenxin ,  CHEN, Honglin ,  XIA, Ningshao

IPC分类号： C07K16/10 ,  C12N15/13 ,  C12N15/63 ,  C12N5/20 ,  A61K39/42 ,  A61P31/16

公开(公告)号：EP3308798A2

公开(公告)日：2018-04-18

申请号：EP17203789.7

申请日：2013-06-06

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： YUAN, Quan ,  ZHANG, Tianying ,  LUO, Wenxin ,  CHEN, Yixin ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： A61K39/12

摘要： The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositons for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.

摘要翻译： 本发明涉及用于治疗乙型肝炎病毒感染的表位肽（或其突变体），包含此类表位肽（或其突变体）和载体蛋白的重组蛋白，以及此类表位肽（或其突变体）和重组蛋白的用途。 本发明还涉及抗此类表位肽的抗体，产生所述抗体的细胞系及其用途。 此外，本发明涉及用于治疗或缓解与乙型肝炎病毒感染相关的一种或多种症状的疫苗或药物组合物，其分别包含根据本发明的重组蛋白或抗体。

公开(公告)号：EP4190802A1

公开(公告)日：2023-06-07

申请号：EP21842399.4

申请日：2021-07-13

申请人： Yang Sheng Tang Company, Ltd. ,  Xiamen University

发明人： YUAN, Quan ,  WANG, Shaojuan ,  NIAN, Sheng ,  WEI, Min ,  ZHANG, Yali ,  WANG, Kai ,  CHEN, Yixin ,  ZHANG, Tianying ,  GE, Shengxiang ,  XIA, Ningshao

IPC分类号： C07K14/02 ,  C07K19/00 ,  A61K38/16 ,  A61K47/42 ,  A61K47/64

摘要： Provided is a cell-penetrating peptide, which can deliver a variety of biological macromolecules, such as proteins, antibodies, nucleic acids and so on into cells across a membrane. In addition, further provided are a fusion protein, conjugate and complex containing the cell-penetrating peptide, and a use of the cell-penetrating peptide.

公开(公告)号：EP3308798B1

公开(公告)日：2020-09-09

申请号：EP17203789.7

申请日：2013-06-06

申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

发明人： YUAN, Quan ,  ZHANG, Tianying ,  LUO, Wenxin ,  CHEN, Yixin ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： A61K39/12

公开(公告)号：EP3305811B1

公开(公告)日：2020-04-01

申请号：EP16802575.7

申请日：2016-06-02

申请人： Xiamen University

发明人： CHEN, Yixin ,  SHEN, Chenguang ,  CHEN, Junyu ,  WANG, Guosong ,  ZHANG, Mengya ,  XIA, Ningshao

IPC分类号： C07K16/10 ,  C12N15/13 ,  C12N15/63 ,  C12N5/20 ,  G01N33/577 ,  G01N33/569 ,  A61K39/42 ,  A61P31/16 ,  C12N7/00

公开(公告)号：EP3308798A3

公开(公告)日：2018-05-30

申请号：EP17203789.7

申请日：2013-06-06

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： YUAN, Quan ,  ZHANG, Tianying ,  LUO, Wenxin ,  CHEN, Yixin ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： A61K39/12

摘要： The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositons for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.

公开(公告)号：EP3305811A1

公开(公告)日：2018-04-11

申请号：EP16802575.7

申请日：2016-06-02

申请人： Xiamen University

发明人： CHEN, Yixin ,  SHEN, Chenguang ,  CHEN, Junyu ,  WANG, Guosong ,  ZHANG, Mengya ,  XIA, Ningshao

IPC分类号： C07K16/10 ,  C12N15/13 ,  C12N15/63 ,  C12N5/20 ,  G01N33/577 ,  G01N33/569 ,  A61K39/42 ,  A61P31/16

摘要： Provided are a broad-spectrum monoclonal anti-Flu B antibody, cell strains generating the antibody, and a composition comprising the antibody; also provided are uses of the antibody for diagnosing, preventing and/or treating an infection of the Flu B and/or diseases caused by the infection.

摘要翻译： 提供广谱单克隆抗Flu B抗体，产生该抗体的细胞株和包含该抗体的组合物; 还提供了抗体用于诊断，预防和/或治疗流感B感染和/或感染引起的疾病的用途。