公开(公告)号：EP3604323A1

公开(公告)日：2020-02-05

申请号：EP18775750.5

申请日：2018-03-29

申请人： Hamari Chemicals, Ltd.

发明人： SUMINO, Fumitoshi ,  DEGUCHI, Ayaka ,  ONO, Rui ,  HIROYAMA, Yuta ,  KANNO, Teruhiko ,  MORIWAKI, Hiroki

IPC分类号： C07K1/04 ,  B01F7/16 ,  B01F7/32 ,  C07K1/34

摘要： An object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a large amount of a peptide. Another object of the present invention is to provide a novel solid phase peptide synthesis method for synthesizing a high-purity long-chain peptide. Still another object of the present invention is to provide a novel solid phase peptide synthesis method causing fewer side reactions. The present invention relates to a method for producing a peptide, and the method comprises solid-phase synthesis of a peptide under stirring with a centrifugal stirrer having no impeller.

公开(公告)号：EP3006449B1

公开(公告)日：2018-01-31

申请号：EP14801345.1

申请日：2014-03-27

申请人： Hamari Chemicals, Ltd.

发明人： MORIWAKI, Hiroki ,  KAWASHIMA, Aki ,  TAKEDA, Ryosuke ,  KAWAMURA, Akie ,  SOLOSHONOK Vadim A.

IPC分类号： C07F15/04 ,  C07C227/32 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C231/18 ,  C07C237/06 ,  C07C319/20 ,  C07C323/58 ,  C07D213/55 ,  C07D223/14 ,  C07B53/00

CPC分类号： C07C227/32 ,  C07B53/00 ,  C07B2200/07 ,  C07C231/18 ,  C07C319/20 ,  C07C2601/02 ,  C07D213/55 ,  C07D223/14 ,  C07F15/045 ,  C07C229/22 ,  C07C229/24 ,  C07C229/30 ,  C07C229/36 ,  C07C229/48 ,  C07C237/08 ,  C07C323/58

摘要： Objects of the present invention are to provide an industrially applicable method for producing an optically active ±-amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ±,±-disubstituted ±-amino acid, and to provide an intermediate useful for the above production methods of an optically active ±-amino acid and an optically active ±,±-disubstituted ±-amino acid. The present invention provides a production method of an optically active ±-amino acid or a salt thereof, the production method comprising introducing a substituent into the ± carbon in the ±-amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure ±-amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.

公开(公告)号：EP2733138A4

公开(公告)日：2014-12-03

申请号：EP12815048

申请日：2012-07-13

申请人： HAMARI CHEMICALS LTD

发明人： MAEDA SADAYUKI ,  SATO TATSUNORI ,  KAWANO YASUHIKO ,  MIYAWAKI TOSHIO

IPC分类号： C07D215/06 ,  B01J31/22 ,  C07B53/00 ,  C07B61/00 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07F15/00 ,  C07F17/02

CPC分类号： C07F5/00 ,  B01J31/181 ,  B01J31/2295 ,  B01J2231/643 ,  B01J2531/0275 ,  B01J2531/827 ,  C07B53/00 ,  C07D215/04 ,  C07D215/06 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/22 ,  C07D215/227 ,  C07F17/02

公开(公告)号：EP0495106B1

公开(公告)日：1995-12-06

申请号：EP90914433.9

申请日：1990-09-28

申请人： ZERIA PHARMACEUTICAL CO., LTD. ,  HAMARI CHEMICALS, LTD.

发明人： YAMAGUCHI, Masayoshi

IPC分类号： A61K31/315 ,  A61K31/415 ,  A61K38/00

CPC分类号： A61K33/30 ,  A61K31/415

摘要： An osteogenesis promoter containing zinc salt or a complex of L-carnosine as an active ingredient, which has an excellent activity of promoting osteogenesis and remarkably reduced toxicity and adverse effects and can be orally administered.

公开(公告)号：EP0322198B1

公开(公告)日：1994-05-18

申请号：EP88312075.0

申请日：1988-12-20

申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

发明人： Karasawa, Michito ,  Otani, Takuzo ,  Uchimoto, Mari ,  Aizawa, Katsuo ,  Kawabe, Hirofumi

IPC分类号： C07D487/22 ,  A61K31/40 ,  A61K49/00

CPC分类号： C07D487/22 ,  A61K41/0071

公开(公告)号：EP0293244A3

公开(公告)日：1990-05-30

申请号：EP88304859.7

申请日：1988-05-27

申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

发明人： Maeda, Sadayuki ,  Nakamura, Usao ,  Sakanaka, Makoto

IPC分类号： C07K5/06

CPC分类号： C07K5/06086 ,  A61K38/00 ,  C07K5/06191

摘要： N ε -Trifluoroacetyl-L-lysyl-L-proline·D-10-camphorsulfonic acid salt is produced in very high purity by reacting Ne-­trifluoroacetyl-L-lysyl-L-proline with D-10-camphorsulfonic acid in a suitable solvent. The salt is extremely stable at ambient temperature as compared with other salts of N ε -trifluoroacetyl-L-lysyl-L-proline including the known dicyclohexylamine salt.

摘要翻译： 通过使Ne-三氟乙酰基-L-赖氨酰-L-脯氨酸与D-10-樟脑磺酸在合适的溶剂中反应，以非常高的纯度产生Nε-三氟乙酰基-L-赖氨酰基-L-脯氨酸·D-10-樟脑磺酸盐。 与包括已知二环己基胺盐的Nε-三氟乙酰基-L-赖氨酰-L-脯氨酸的其他盐相比，盐在环境温度下非常稳定。

公开(公告)号：EP0192317B1

公开(公告)日：1990-02-28

申请号：EP86300076.6

申请日：1986-01-07

申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

发明人： Takaya, Masahiro

IPC分类号： C07D233/64 ,  A61K31/415

CPC分类号： C07D233/64

公开(公告)号：EP0322198A3

公开(公告)日：1989-12-20

申请号：EP88312075.0

申请日：1988-12-20

申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

发明人： Karasawa, Michito ,  Otani, Takuzo ,  Uchimoto, Mari ,  Aizawa, Katsuo ,  Kawabe, Hirofumi

IPC分类号： C07D487/22 ,  A61K31/40 ,  A61K49/00

CPC分类号： C07D487/22 ,  A61K41/0071

摘要： Novel pheophoribide derivative of the general formula:
(wherein Z is O or NH; n is an integer of 1 to 6; Y is NR′R˝ or
(wherein R′, R˝ and R‴ are the same or different and each represents a C₁ to C₄ lower alkyl group; and X⁻ is a halogen or organic acid ion); R₁ is an ethenyl group, C₁ to C₄ lower alkyl group or
(wherein m is an integer of 0 to 6, R₆ is H or a C₁ to C₄ lower alkyl group); R₂ is CH₃, CHO or CH₂OH; either of R₃ and R₄ is H, with the other being OH, or both of them combine to represent =O; R₅ is H or CO₂CH₃) are useful in photodynamic diagnosis and therapy of cancer tissues.

公开(公告)号：EP0192317A1

公开(公告)日：1986-08-27

申请号：EP86300076.6

申请日：1986-01-07

申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

发明人： Takaya, Masahiro

IPC分类号： C07D233/64 ,  A61K31/415

CPC分类号： C07D233/64

摘要： Homocarnosine or acylhomocarnosine aluminum and zinc salts of the formula:
wherein R represents a hydrogen atom or an acyl group; M represents a zinc atom or an aluminum atom; a denotes 1, 2 or 3; and b denotes 0,1 or 2, provided that when a denotes 1, b denotes 0 and M represents zinc, a hydrogen atom is omitted from the homocarnosine or acylhomocarnosine residue, have antiulcer and wound healing-promoting activities and very low toxicity.

摘要翻译： 同型半胱氨酸或酰基焦马来诺铝和下式的锌盐：其中R表示氢原子或酰基; M表示锌原子或铝原子; a表示1,2或3; 并且b表示0,1或2，条件是当a表示1时，b表示0且M表示锌，从高卡诺胶或酰基卡马诺糖残基中省略氢原子，具有抗溃疡和伤口愈合促进活性，毒性非常低。

公开(公告)号：EP0121444A3

公开(公告)日：1986-08-13

申请号：EP84302316

申请日：1984-04-04

申请人： HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD.

发明人： Nakamura, Usao ,  Takao, Makoto ,  Ueno, Etsuko ,  Kawaguchi, Kichitaro

IPC分类号： C12P13/00 ,  C12R01/01

CPC分类号： C12P13/007

摘要： L-carntine is produced by bringing apocarnitine into contact with hydrase produced by a strain of Enterobacter in an aqueous medium having a pH of 4-10 at a temperature of 20-60°C, thereby apocarnintine is converted to L-carnitine.