利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

131 条记录 (耗时 0.037 秒)

    REGULATORY ELEMENTS FROM LABYRINTHULOMYCETES MICROORGANISMS
    8.
    发明公开
    REGULATORY ELEMENTS FROM LABYRINTHULOMYCETES MICROORGANISMS 审中-公开
    调控微量元素的研究

    公开(公告)号：EP3265567A1

    公开(公告)日：2018-01-10

    申请号：EP16759329.2

    申请日：2016-02-29

    申请人： Synthetic Genomics, Inc.

    发明人： CAIAZZA, Nicky, C. ,  WIN, Maung, Nyan ,  URANO, Jun

    IPC分类号： C12N15/63 ,  C12N15/80 ,  C12N15/113 ,  C12Q1/68

    摘要： The present disclosure generally relates to novel polynucleotide molecules for use in regulating gene expression in recombinant cells, such as labyrinthulomycetes cells. The disclosure further relates to nucleic acid constructs, such as vectors and expression cassettes, containing a regulatory element operably linked to a heterologous nucleotide sequence. The disclosure further relates to methods for stably transforming a host cell, such as a labyrinthulomycetes cell with transgenes. Stably transformed recombinant cells, progeny, biomaterials derived therefrom, and methods for preparing and using the same are also provided.

    COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF
    9.
    发明公开
    COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF 审中-公开

    公开(公告)号：EP3119899A4

    公开(公告)日：2017-11-29

    申请号：EP15764217

    申请日：2015-03-20

    申请人： SYNTHETIC GENOMICS INC

    发明人： KAMBOURAKIS SPIROS ,  GRIFFIN BENJAMIN M ,  MARTIN KEVIN V

    IPC分类号： C12P7/58 ,  C12N9/04 ,  C12P7/42 ,  C12P7/44 ,  C12P17/04 ,  C12P17/06

    CPC分类号： C12P7/58 ,  C12P7/44 ,  C12P17/06

    摘要： The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention.