公开(公告)号：EP1755443A4

公开(公告)日：2011-07-06

申请号：EP05738702

申请日：2005-04-14

申请人： THERASENSE INC

发明人： REGGIARDO CHRISTOPHER V

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046 ,  A61B2562/182

公开(公告)号：EP1552146A2

公开(公告)日：2005-07-13

申请号：EP03770727.0

申请日：2003-10-09

申请人： Therasense, Inc.

发明人： RUSH, Benjamin ,  REGGIARDO, Christopher, V.

IPC分类号： F04B23/08

CPC分类号： F04B43/043 ,  A61M5/14216 ,  A61M5/14244 ,  A61M2205/0266 ,  A61M2205/0288 ,  A61M2205/3317 ,  A61M2205/702 ,  F03G7/065 ,  F04B13/00 ,  F04B17/03 ,  F04B19/22 ,  F04B43/08 ,  F04B49/065 ,  F04B51/00 ,  F04B2205/09 ,  F05C2251/08 ,  G01F11/021

摘要： A system for the metering and delivery of small discrete volumes of liquid, comprised of a minimal number of inexpensive components. Fluid (103) is moved rrom a resrvoir (102) through a displacement chamber (104) by movement of a plunger (112). The plunger (112) is moved from a first limit (105) to a second limit (106) by an acuator comprised of a shape memory alloy (114) ans biasing spring (115). Electrical current is supplied to the shape memory alloy (114) by a control circuit (116) that cycles the movement of the plunger (112).

公开(公告)号：EP1119637B8

公开(公告)日：2004-07-28

申请号：EP99951856.6

申请日：1999-10-08

申请人： Therasense, Inc.

发明人： FELDMAN, Benjamin, J. ,  HELLER, Adam ,  HELLER, Ephraim ,  MAO, Fei ,  VIVOLO, Joseph, A. ,  FUNDERBURK, Jeffery, V. ,  COLMAN, Fredric, C. ,  KRISHNAN, Rajesh

IPC分类号： C12Q1/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散氧化还原介体的传感器。 传感器包括样品室以保持与工作电极电解接触的样品，并且在至少一些情况下，传感器还包含不可滤出或可扩散的第二电子转移剂。 传感器和/或使用的方法响应于分析物产生传感器信号，该分析物可以与由介体引起的背景信号区分开。 本发明可用于使用诸如库仑法，电流分析法和电位滴定法之类的技术来测定诸如血液或血清的生物流体中的生物分子例如葡萄糖或乳酸盐的浓度。 通常提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：EP1230249B1

公开(公告)日：2004-06-02

申请号：EP00978635.1

申请日：2000-11-14

申请人： Therasense, Inc.

发明人： MAO, Fei ,  HELLER, Adam

IPC分类号： C07F15/00 ,  C12Q1/00 ,  G01N27/49

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/1477 ,  C07F9/005 ,  C07F15/0026 ,  C07F15/0053 ,  C07F15/025 ,  C07F15/065 ,  C08F8/42 ,  C08F8/44 ,  C09B57/10 ,  C12Q1/004

摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons form, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.

公开(公告)号：EP1875220A4

公开(公告)日：2010-04-07

申请号：EP06750346

申请日：2006-04-13

申请人： THERASENSE INC

发明人： RUSH BENJAMIN M

IPC分类号： G01N27/403 ,  A61M5/142 ,  F04B1/00 ,  F04B17/00 ,  F04B17/04 ,  F04B43/04 ,  F04B49/06 ,  F04B51/00 ,  G01F1/708 ,  G01F25/00 ,  G01N27/416

CPC分类号： G01F1/7088 ,  A61M5/14216 ,  A61M5/14244 ,  A61M5/16886 ,  A61M2005/1726 ,  A61M2205/0288 ,  A61M2205/3317 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/702 ,  F04B43/043 ,  F04B49/065 ,  F04B51/00 ,  F04B2205/09 ,  F05C2251/08 ,  G01F1/64 ,  G01F1/708 ,  G01F25/0007

公开(公告)号：EP1507785A4

公开(公告)日：2007-12-19

申请号：EP02807613

申请日：2002-05-10

申请人： THERASENSE INC

发明人： MAO FEI ,  HELLER ADAM

IPC分类号： C07F15/00 ,  G01N27/327

CPC分类号： C07F15/0026

摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme-based electrochemical sensors. The transition metal complexes include substituted or unsubstituted (pyridyl)imidazole ligands. Transition metal complexes attached to polymeric backbones are also described.

摘要翻译： 描述了新的铁，钴，钌，锇和钒的过渡金属络合物。 过渡金属配合物可用作基于酶的电化学传感器中的氧化还原介体。 过渡金属络合物包括取代或未取代的（吡啶基）咪唑配体。 还描述了连接到聚合物骨架的过渡金属络合物。

公开(公告)号：EP1718198A2

公开(公告)日：2006-11-08

申请号：EP05723142.5

申请日：2005-02-16

申请人： Therasense, Inc.

发明人： SLOAN, Mark, K.

IPC分类号： A61B5/00 ,  G06F19/00

CPC分类号： A61M5/1723 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/14532 ,  A61M2205/3592 ,  G06F19/3418 ,  H04B7/24 ,  H04L7/002 ,  H04L7/0079 ,  H04L7/0091

摘要： Method and system for providing data monitoring and management including RF communication link over which a transmitter and a receiver is configured to communicate, the transmitter configured to periodically transmit a data packet associated with a detected analyte level received from an analyte sensor, and the receiver configured to identify the transmitter as the correct transmitter for which it is configured to receive the data packets, and to continue to receive the data packets from the transmitter once the transmitter identification has been verified, is provided.

公开(公告)号：EP1355568A4

公开(公告)日：2006-08-16

申请号：EP01994499

申请日：2001-12-28

申请人： THERASENSE INC

发明人： HELLER ADAM ,  DRUCKER STEVEN M ,  JIN ROBERT Y ,  FUNDERBURK JEFFERY V

IPC分类号： G01N27/416 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1486 ,  A61N1/08 ,  A61B1/00

CPC分类号： A61B5/1495 ,  A61B5/0002 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/076 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6832 ,  A61B5/6833 ,  A61B5/6849 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/743 ,  A61B5/7445 ,  A61B2560/0252 ,  A61B2560/0412 ,  A61B2560/063 ,  A61N1/08 ,  H04B1/707 ,  H04L1/0071

摘要： A method of communicating a digital signal representing a level of an analyte in a bodily fluid, the method comprising: assembling a plurality of data words into a data message, at least one of the data words containing data derived from the digital signal representing a level of an analyte in a bodily fluid, each of the data words comprising a set of bits, wherein for at least two of the data words, the set of bits are organized into a set of data bits and a set of error correction bits; and transmitting the data message, such that the bits comprising one of the pluralities of data words assembled into the data message are not transmitted contiguously.

公开(公告)号：EP1578262A2

公开(公告)日：2005-09-28

申请号：EP03808614.6

申请日：2003-12-26

申请人： Therasense, Inc.

发明人： ROBERT, Jin, Y. ,  SLOAN, Mark, K.

IPC分类号： A61B5/00

CPC分类号： A61B5/01 ,  A61B5/0002 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00

摘要： A continuous glucose monitoring system including a sensor configured to detect one or more glucose levels, a transmitter operatively coupled to the sensor, the transmitter configured to receive the detected one or more glucose levels, the transmitter further configured to transmit signals corresponding to the detected one or more glucose levels, and a receiver operatively coupled to the transmitter configured to receive transmitted signals corresponding to the detected one or more glucose levels, and methods thereof, are disclosed. In one aspect, the transmitter may be configured to transmit a current data point and at least one previous data point, the current data point and the at least one previous data point corresponding to the detected one or more glucose levels.

公开(公告)号：EP1230249A1

公开(公告)日：2002-08-14

申请号：EP00978635.1

申请日：2000-11-14

申请人： Therasense, Inc.

发明人： MAO, Fei ,  HELLER, Adam

IPC分类号： C07F15/00 ,  C12Q1/00 ,  G01N27/49

CPC分类号： A61B5/1486 ,  A61B5/14532 ,  A61B5/1477 ,  C07F9/005 ,  C07F15/0026 ,  C07F15/0053 ,  C07F15/025 ,  C07F15/065 ,  C08F8/42 ,  C08F8/44 ,  C09B57/10 ,  C12Q1/004

摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons form, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.