公开(公告)号：EP1119637B8

公开(公告)日：2004-07-28

申请号：EP99951856.6

申请日：1999-10-08

申请人： Therasense, Inc.

发明人： FELDMAN, Benjamin, J. ,  HELLER, Adam ,  HELLER, Ephraim ,  MAO, Fei ,  VIVOLO, Joseph, A. ,  FUNDERBURK, Jeffery, V. ,  COLMAN, Fredric, C. ,  KRISHNAN, Rajesh

IPC分类号： C12Q1/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

摘要翻译： 描述了利用不可浸出或可扩散氧化还原介体的传感器。 传感器包括样品室以保持与工作电极电解接触的样品，并且在至少一些情况下，传感器还包含不可滤出或可扩散的第二电子转移剂。 传感器和/或使用的方法响应于分析物产生传感器信号，该分析物可以与由介体引起的背景信号区分开。 本发明可用于使用诸如库仑法，电流分析法和电位滴定法之类的技术来测定诸如血液或血清的生物流体中的生物分子例如葡萄糖或乳酸盐的浓度。 通常提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

公开(公告)号：EP1119637A1

公开(公告)日：2001-08-01

申请号：EP99951856.6

申请日：1999-10-08

申请人： Therasense, Inc.

发明人： FELDMAN, Benjamin, J. ,  HELLER, Adam ,  HELLER, Ephraim ,  MAO, Fei ,  VIVOLO, Joseph, A. ,  FUNDERBURK, Jeffery, V. ,  COLMAN, Fredric, C. ,  KRISHNAN, Rajesh

IPC分类号： C12Q1/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：EP1145000B1

公开(公告)日：2005-05-11

申请号：EP00973899.8

申请日：2000-10-27

申请人： Therasense, Inc.

发明人： LIAMOS, Charles, T. ,  FELDMAN, Benjamin, J. ,  FUNDERBURK, Jeffery, V. ,  KRISHNAN, Rajesh ,  PLANTE, Phillip, J. ,  VIVOLO, Joseph, A. ,  JIN, Robert, Y. ,  CLOUD, Michael, S. ,  COLMAN, Fredric, C.

IPC分类号： G01N33/487 ,  G01N33/543 ,  G01N27/42

CPC分类号： G01N27/3272 ,  Y10S439/909

摘要： A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.

公开(公告)号：EP1145000B8

公开(公告)日：2005-09-14

申请号：EP00973899.8

申请日：2000-10-27

申请人： Therasense, Inc.

发明人： LIAMOS, Charles, T. ,  FELDMAN, Benjamin, J. ,  FUNDERBURK, Jeffery, V. ,  KRISHNAN, Rajesh ,  PLANTE, Phillip, J. ,  VIVOLO, Joseph, A. ,  JIN, Robert, Y. ,  CLOUD, Michael, S. ,  COLMAN, Fredric, C.

IPC分类号： G01N33/487 ,  G01N33/543 ,  G01N27/42

CPC分类号： G01N27/3272 ,  Y10S439/909

摘要： A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.

摘要翻译： 小体积传感器以及制造方法，用于使用诸如库仑法，电流分析法和电位滴定法之类的技术来测定诸如血液或血清的生物流体中诸如葡萄糖或乳酸盐的分析物的浓度。 传感器包括工作电极和反电极，并且可以包括插入监测迹线以确定传感器在连接器中的正确定位。 在一个实施例中，传感器通过将一定量的电荷释放到样品中来确定分析物的浓度，确定释放电荷所需的时间，并且使用电荷量来确定用于电解一部分分析物的电流，并且 多少时间。

公开(公告)号：EP1119637B1

公开(公告)日：2004-03-24

申请号：EP99951856.6

申请日：1999-10-08

申请人： Therasense, Inc.

发明人： FELDMAN, Benjamin, J. ,  HELLER, Adam ,  HELLER, Ephraim ,  MAO, Fei ,  VIVOLO, Joseph, A. ,  FUNDERBURK, Jeffery, V. ,  COLMAN, Fredric, C. ,  KRISHNAN, Rajesh

IPC分类号： C12Q1/00

CPC分类号： G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  C12Q1/32 ,  G01N27/3271 ,  G01N27/3274 ,  Y10T29/49002 ,  Y10T29/49004 ,  Y10T29/49007 ,  Y10T29/49126 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49147 ,  Y10T29/49155 ,  Y10T29/49204 ,  Y10T29/49208 ,  Y10T29/4921 ,  Y10T29/49794 ,  Y10T156/1052

摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

公开(公告)号：EP1145000A1

公开(公告)日：2001-10-17

申请号：EP00973899.8

申请日：2000-10-27

申请人： Therasense, Inc.

发明人： LIAMOS, Charles, T. ,  FELDMAN, Benjamin, J. ,  FUNDERBURK, Jeffery, V. ,  KRISHNAN, Rajesh ,  PLANTE, Phillip, J. ,  VIVOLO, Joseph, A. ,  JIN, Robert, Y. ,  CLOUD, Michael, S. ,  COLMAN, Fredric, C.

IPC分类号： G01N33/487 ,  G01N33/543 ,  G01N27/42

CPC分类号： G01N27/3272 ,  Y10S439/909

摘要： A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.