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公开(公告)号：EP3094347A4
公开(公告)日：2018-04-04
申请号：EP15737898
申请日：2015-01-13
发明人： LI KING , MINTZ AKIVA , XIONG XIAOBING , JUNG YOUNGKYOO , SUN YAO
IPC分类号： A61K39/00 , A61K35/28 , A61K35/30 , A61K35/545 , A61K38/18 , A61K38/19 , A61K41/00 , A61K45/06 , A61K48/00 , A61P35/00 , C07H21/04
CPC分类号： A61K48/0083 , A61K9/0019 , A61K35/28 , A61K35/30 , A61K35/545 , A61K38/1841 , A61K38/1866 , A61K38/19 , A61K38/191 , A61K41/0047 , A61K45/06 , A61K48/005 , A61K48/0058 , A61K48/0066 , A61M37/0092 , A61P35/00 , C07K14/49 , C07K14/495 , C07K14/52 , C07K14/525 , C12N15/86 , C12N2830/002
摘要： A method of increasing blood-brain barrier permeability of selected brain tissue in a subject in need thereof is carried out by: (a) parenterally administering to the subject stem cells that migrate to the brain tissue, the stem cells containing a recombinant nucleic acid, the recombinant nucleic acid comprising a nucleic acid encoding a barrier-opening protein or peptide operably associated with a heat-inducible promoter; and then (b) selectively heating the selected brain tissue sufficient to induce the expression of the barrier-opening protein or peptide in an amount effective to increase the permeability of the blood-brain barrier in the selected brain tissue. Nucleic acids, vectors, stem cells and compositions useful for carrying out such methods are also described.
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2.发明公开AMNIOTIC MEMBRANE AND ITS USE IN WOUND HEALING AND TISSUE ENGINEERING CONSTRUCTS 审中-公开羊膜及它们在伤口愈合和组织生长构建体
公开(公告)号：EP2897625A4
公开(公告)日：2016-08-17
申请号：EP13834448
申请日：2013-09-10
发明人： SKARDAL ALEKSANDER , ATALA ANTHONY , MURPHY SEAN V
IPC分类号： A61L27/36 , A61K31/74 , A61K35/50 , A61L15/40 , A61L26/00 , A61L27/34 , A61L27/48 , A61L27/52 , C12N5/00
CPC分类号： A61K35/50 , A61K47/36 , A61K47/42 , A61L15/40 , A61L26/0057 , A61L26/0076 , A61L27/34 , A61L27/3604 , A61L27/3683 , A61L27/48 , A61L27/52 , A61L2430/40 , C12N5/0068 , C12N2533/92 , C08L89/00
摘要： The present invention provides compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane of the placenta. In certain embodiments, the composition comprises amniotic membrane powder or solubilized amniotic membrane (SAM). In some aspects, the composition is cell-free and rich in cytokines, extracellular matrix proteins, and other components that improve tissue regeneration. In one aspect, the composition is a hydrogel scaffold that comprises amniotic membrane. The present invention reduces contraction and improves blood vessel development in regenerating tissue.
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公开(公告)号：EP2718864A4
公开(公告)日：2016-06-29
申请号：EP12796912
申请日：2012-06-08
发明人： JOYCE KAREN E , LAURIENTI PAUL J , HAYASAKA SATORU
摘要： An agent-based modeling system for predicting and/or analyzing brain behavior is provided. The system includes a computer processor configured to define nodes and edges that interconnect the nodes. The edges are defined by physiological interactions and/or anatomical connections. The computer processor further defines rules and/or model parameters that define a functional behavior of the nodes and edges. The computer processor assigns the nodes to respective brain regions, and the rules and/or model parameters are defined by observed physiological interaction of the nodes that are functionally and/or structurally connected by said edges of brain regions to thereby provide an agent-based brain model (ABBM) for predicting and/or analyzing brain behavior.
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4.发明公开AUTOMATED RENAL EVALUATION SYSTEMS AND METHODS USING MRI IMAGE DATA 审中-公开AUTOMATED肾评估系统和方法使用MRI图像数据
公开(公告)号：EP2765908A4
公开(公告)日：2015-10-07
申请号：EP12839542
申请日：2012-10-10
IPC分类号： A61B5/026 , A61B5/01 , A61B5/055 , A61B5/145 , A61B5/20 , G01R33/50 , G01R33/56 , G01R33/563 , G06T7/00
CPC分类号： A61B5/004 , A61B5/015 , A61B5/0263 , A61B5/055 , A61B5/14542 , A61B5/201 , A61B5/4848 , A61B5/4872 , A61M5/14 , G01R33/50 , G01R33/5601 , G01R33/5608 , G01R33/5635 , G01R33/56366
摘要： Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents.
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5.发明公开ONE-CARD PRESBYOPIA SYSTEMS AND RELATED METHODS 审中-公开EINSCHRITT-SYSTEME ZUR KORREKTUR VON ALTERSWEITSICHTIGKEIT UND ENTSPRECHENDE VERFAHREN
公开(公告)号：EP2629722A4
公开(公告)日：2015-06-17
申请号：EP11835057
申请日：2011-10-19
CPC分类号： A61F9/00802 , A61B34/10 , A61B34/25 , A61B2034/108 , A61F9/00808 , A61F2009/00872 , A61F2009/00878 , A61F2009/00895
摘要： Methods and systems for correcting presbyopia using a surgical excimer laser include activating the laser once and transmitting a pre-defined three dimensional ablation profile to treat presbyopia based on the single activating step.
摘要翻译： 使用外科准分子激光器校正老花眼的方法和系统包括激活激光一次，并且基于单个激活步骤传输预定义的三维消融轮廓以治疗老花眼。
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公开(公告)号：EP2542564A4
公开(公告)日：2014-05-07
申请号：EP11751497
申请日：2011-03-07
CPC分类号： C07K14/4741 , A61L15/32 , A61L15/44 , A61L15/60 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/406 , A61L2300/414 , C08L89/04
摘要： Provided herein are keratin compositions (e.g., keratin gels, scaffolds, particulates, and the like) including a compound of interest, useful for release and/or delivery of the compound of interest (e.g., in vivo or in vitro). In some embodiments, the composition is a composition formulated for controlled release of the compound of interest.
摘要翻译： 本文提供了包括目标化合物的角蛋白组合物（例如，角蛋白凝胶，支架，颗粒等），其用于释放和/或递送目的化合物（例如体内或体外）。 在一些实施方案中，组合物是配制用于感兴趣化合物的受控释放的组合物。
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7.发明公开METHODS FOR MAKING A TISSUE ENGINEERED MUSCLE REPAIR (TEMR) CONSTRUCT IN VITRO FOR IMPLANTATION IN VIVO 有权组织修复肌肉育成的体外生产方法来开发植入体内
公开(公告)号：EP2603580A4
公开(公告)日：2014-04-09
申请号：EP11817111
申请日：2011-08-12
发明人： CHRIST GEORGE J , CORONA BENJAMIN T
IPC分类号： C12N5/071
CPC分类号： A61L27/3895 , A61F2/08 , A61F2002/0894 , A61K35/12 , A61K35/34 , A61L27/3826 , A61L27/3873 , C12M35/02 , C12N5/0658 , C12N5/0697 , C12N2527/00 , C12N2533/54 , C12N2533/90
摘要： Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.
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公开(公告)号：EP2486154A4
公开(公告)日：2013-03-06
申请号：EP10822794
申请日：2010-10-08
发明人： TORTI FRANK M , TORTI SUZY V , MILLER LANCE
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57415 , G01N33/57449 , G01N33/57484 , G01N33/57492 , G01N33/57496 , G01N2500/10 , G01N2800/54 , G01N2800/60
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9.发明公开MEDICAL TOOLS FOR FACILITATING DEEP LAMELLAR ENDOTHELIAL KERATOPLASTY AND RELATED METHODS 有权的医疗工具，以方便深板层角膜内皮移植术及相关手续
公开(公告)号：EP1981437A4
公开(公告)日：2011-06-08
申请号：EP07709821
申请日：2007-01-25
发明人： WALTER KEITH ANDREW , WEBER KURT
IPC分类号： A61F2/14
CPC分类号： A61F2/148 , A61F2/0095 , A61F2/142 , A61F9/007
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公开(公告)号：EP2146728A4
公开(公告)日：2010-12-29
申请号：EP08754571
申请日：2008-05-20
发明人： ZHANG YUANYUAN , ATALA ANTHONY
CPC分类号： A61L27/3882 , A61K35/12 , A61L27/3804 , A61L2430/22 , C12N5/0685 , C12N2500/40 , C12N2501/01 , C12N2501/11 , C12N2501/39 , C12N2501/395
摘要： Provided herein are urine progenitor cells and methods for producing a culture of urine progenitor cells from a urine sample. The cells may be selected based upon the use of a selective cell medium, based upon morphology, and/or by selecting cell-specific markers. Also provided is an isolated urine progenitor cell that is c-kit positive and can differentiate into urothelium, smooth muscle, endothelium or interstitial cells. Methods of use of urine progenitor cells are provided, wherein cell are seeded onto a tissue scaffold are provided. Methods of treating a subject in need thereof are also provided, including providing a bladder tissue substrate that includes differentiated UPCs and transplanting the substrate into the patient. Finally, kits are provided that include a container suitable for the transport of a urine sample; media; one or more antibiotics; a package for holding said container, media, and antibiotics; and optionally, instructions for use.
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