公开(公告)号：EP1940543A2

公开(公告)日：2008-07-09

申请号：EP06825335.0

申请日：2006-09-29

申请人： Siemens Medical Solutions USA, Inc.

发明人： ELIZAROV, Arkadij M. ,  KOLB, Hartmuth ,  HEATH, James ,  VAN DAM, R. Michael

IPC分类号： B01J19/00

CPC分类号： B01F11/0042 ,  B01F11/0071 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00916 ,  B01J2219/00927 ,  B01J2219/00986

摘要： The invention concerns automated, inegrated microfluidic devices comprising a chemical reaction chip for performing reactions, such as the preparation of radiopharmaceutical compounds. The chip comprises an integrated microscale column and is configured for liquid flow from the column to at least one flow channel. The fluid flow is controlled by at least two on-chip valves. These double valves are configured consecutively and within proximity of 300 micrometer from each other. The reaction chamber is substantially 'coinshaped', e.g. a reaction cylinder, preferably having a height diameter to height ratio greater than 3. Curved inlet and outlet channels ensure en effective elution.

公开(公告)号：EP3271065A1

公开(公告)日：2018-01-24

申请号：EP16710190.6

申请日：2016-03-16

申请人： GE Healthcare Limited

发明人： DUMONT, Philippe

IPC分类号： B01J19/00 ,  A61K51/04

CPC分类号： B01J19/0093 ,  B01J19/004 ,  B01J2219/00799 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00894 ,  B01J2219/00918 ,  B01J2219/00927 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/00986 ,  C07B59/00 ,  C07B2200/05

摘要： The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator.

公开(公告)号：EP2701836A1

公开(公告)日：2014-03-05

申请号：EP12728827.2

申请日：2012-04-27

申请人： R Bio Transfer S.R.L.

发明人： AZZI, Carlo ,  CASTELLANO, Claudia ,  AVERSANO, Francesca

IPC分类号： B01J19/00 ,  A61K51/08

CPC分类号： B01J19/00 ,  B01J19/004 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00376 ,  B01J2219/00495 ,  B01J2219/00599 ,  B01J2219/00698 ,  B01J2219/00725 ,  B01J2219/00788 ,  B01J2219/00806 ,  B01J2219/0081 ,  B01J2219/00817 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00927

摘要： The present invention concerns an automatic device for the synthesis of peptide-based radioactive drugs, for diagnostic and/or therapeutic use, comprising: - a structure frame (100); - a possible closing case (200) for said structure frame (100); - a first disposable main module (1 ); - a second disposable module (19), slidingly associated with said first main module (1); - a third disposable test-tube holder module (26), reversibly fixable to said structure frame (100) with fixing means that allow the translation thereof with respect to the same. Said first (1), second (19) and third (26) module are arranged for irreversibly coupling so as to form one single disposable collector (300) inside which the whole synthesis process of the concerned radioactive drug is performed, where at the end of the process, said collector (300) may be removed from the device as one single contaminated mono block. The device is controlled by a remote control and drive workstation (39) that comprises a personal computer (PC) through which the operator may interact with the whole synthesis process, as well as devices (PE) for storing and managing the data concerning the synthesis of the specific radioactive drug obtained for each single treated patient.

公开(公告)号：EP1204469A4

公开(公告)日：2003-04-16

申请号：EP00930803

申请日：2000-05-17

申请人： MARCHITTO KEVIN S ,  FLOCK STEPHEN T

发明人： MARCHITTO KEVIN S ,  FLOCK STEPHEN T

IPC分类号： B01J19/00 ,  B01J19/12 ,  B01L3/00 ,  C40B60/14 ,  G21K1/00 ,  H05H3/04 ,  B01J19/08 ,  C02F1/04 ,  C02F1/30 ,  C02F1/32

CPC分类号： G21K1/006 ,  B01J19/0046 ,  B01J19/0093 ,  B01J19/121 ,  B01J19/126 ,  B01J19/127 ,  B01J19/129 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00781 ,  B01J2219/00891 ,  B01J2219/00925 ,  B01J2219/00927 ,  B01J2219/00934 ,  B01J2219/00941 ,  B01J2219/00943 ,  B01J2219/00948 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/089 ,  B01L2400/0454 ,  C40B60/14 ,  H05H3/04

摘要： The present invention provides electromagnetic energy driven separation methods, including methods for separating molecules in a mixture, for increasing diffusion rate of a substance in a medium, and for moving fluids on a substrate. Such methods work with extremely small volumes of target and may be used for medical diagnosis and treatment. The method of the figure involves providing a laser pulse to create pressure waves in a matrix, the pressure waves creating a force on particles in the matrix such that the diffusion rate of particles in the matrix is increased relative to its surrounding environment.

公开(公告)号：EP1204469A1

公开(公告)日：2002-05-15

申请号：EP00930803.2

申请日：2000-05-17

申请人： Marchitto, Kevin S. ,  Flock, Stephen T.

发明人： Marchitto, Kevin S. ,  Flock, Stephen T.

IPC分类号： B01J19/08 ,  C02F1/04 ,  C02F1/30 ,  C02F1/32

CPC分类号： G21K1/006 ,  B01J19/0046 ,  B01J19/0093 ,  B01J19/121 ,  B01J19/126 ,  B01J19/127 ,  B01J19/129 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00781 ,  B01J2219/00891 ,  B01J2219/00925 ,  B01J2219/00927 ,  B01J2219/00934 ,  B01J2219/00941 ,  B01J2219/00943 ,  B01J2219/00948 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/089 ,  B01L2400/0454 ,  C40B60/14 ,  H05H3/04

摘要： The present invention provides electromagnetic energy driven separation methods, including methods for separating molecules in a mixture, for increasing diffusion rate of a substance in a medium, and for moving fluids on a substrate. Such methods work with extremely small volumes of target and may be used for medical diagnosis and treatment. The method of the figure involves providing a laser pulse to create pressure waves in a matrix, the pressure waves creating a force on particles in the matrix such that the diffusion rate of particles in the matrix is increased relative to its surrounding environment.

公开(公告)号：EP2934741A1

公开(公告)日：2015-10-28

申请号：EP13815495.0

申请日：2013-12-20

申请人： GE Healthcare UK Limited

发明人： SRIVASTAVA, Alok, M ,  SAMPER, Victor ,  RIESE, Stefan

IPC分类号： B01J19/00 ,  G01T1/00

CPC分类号： G01T7/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00927 ,  B01J2219/00954 ,  B01J2219/00968 ,  G01T1/10

摘要： The present invention uses the concept that radiation-sensitive material (4) embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. The invention provides a device comprising at least one piece of a radiation-sensitive material (4), and a method to measure the radiation dose associated with radiolabelled compound produced by said device.

公开(公告)号：EP2593218A2

公开(公告)日：2013-05-22

申请号：EP11801964.5

申请日：2011-07-05

申请人： ABX Advanced Biochemical Compounds GmbH

发明人： MÜLLER, Marco

IPC分类号： B01J19/00 ,  B01L3/00 ,  C07B59/00 ,  C07H5/02

CPC分类号： C07B59/005 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/0081 ,  B01J2219/00813 ,  B01J2219/00817 ,  B01J2219/00891 ,  B01J2219/00898 ,  B01J2219/00916 ,  B01J2219/00927 ,  C07B59/00 ,  C07B2200/05 ,  C07H5/02 ,  Y02P20/55

摘要： The invention relates to a device for synthesizing radiotracers, comprising: a reaction vessel for reacting a precursor compound containing protective groups with a radioactive isotope so as to obtain a first reaction product; a first cartridge for separating protective groups from the first reaction product so as to obtain a second reaction product; and a second cartridge for purifying the second reaction product. The reaction vessel, the first cartridge, and the second cartridge are interconnected via pipes. According to the invention, the first cartridge contains 801 to 1200 mg of a solid carrier, and/or the reaction vessel is made of a temperature-resistant plastic that has a thermal resistance of at least 120°C.

公开(公告)号：EP2456551A1

公开(公告)日：2012-05-30

申请号：EP10736848.2

申请日：2010-07-21

申请人： InSolutions B.V.

发明人： BACKX, Antonius Cornelis Petrus Maria

IPC分类号： B01J19/08 ,  B01J37/34 ,  B01J19/00

CPC分类号： B01J19/08 ,  B01J19/0093 ,  B01J2219/00835 ,  B01J2219/00853 ,  B01J2219/00927 ,  B01J2219/0892 ,  B01J2219/0896

摘要： The invention provides a process for the production of a compound comprising (a) providing a reactor with a reactor volume containing a catalyst on a support, (b) providing one or more starting products in the reactor volume while maintaining the reactor volume under non-reactive (inhibited) conditions for the one or more starting products, (c) subsequently providing an energy pulse to the reactor volume the pulse having an energy sufficient to start a catalytic reaction of the one or more starting products to provide a reaction product comprising the compound, and (d) subsequently removing the reaction product from the reactor volume.

公开(公告)号：EP3271064A1

公开(公告)日：2018-01-24

申请号：EP16710185.6

申请日：2016-03-16

申请人： GE Healthcare Limited

发明人： DUMONT, Philippe

IPC分类号： B01J19/00 ,  A61K51/04

CPC分类号： B01J19/004 ,  B01J19/0093 ,  B01J2219/00058 ,  B01J2219/00799 ,  B01J2219/00833 ,  B01J2219/00867 ,  B01J2219/00894 ,  B01J2219/00918 ,  B01J2219/00927 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/00986 ,  C07B59/00 ,  C07B2200/05

摘要： The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.

公开(公告)号：EP3268124A1

公开(公告)日：2018-01-17

申请号：EP16709088.5

申请日：2016-03-10

申请人： GE Healthcare Limited

发明人： FRANCI, Xavier ,  DUMONT, Philippe ,  LIGNON, Steve ,  LANGE, Audrey, Marie ,  VERBRUGGE, Nicolas

IPC分类号： B01J19/00 ,  A61K51/04

CPC分类号： B01J19/004 ,  A61K51/0491 ,  B01J19/0093 ,  B01J19/18 ,  B01J2219/00799 ,  B01J2219/00833 ,  B01J2219/00862 ,  B01J2219/00867 ,  B01J2219/00894 ,  B01J2219/00916 ,  B01J2219/00918 ,  B01J2219/00927 ,  B01J2219/00952 ,  C07B2200/05 ,  C07H5/02

摘要： The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.