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公开(公告)号：EP2049476A1
公开(公告)日：2009-04-22
申请号：EP07787758.7
申请日：2007-07-20
申请人： ZaCh System S.p.A.
发明人： FORCATO, Massimiliano , MICHIELETTO, Ivan , MARAGNI, Paolo , MASSACCESI, Franco , COTARCA, Livius
IPC分类号： C07D207/27
CPC分类号： C07D207/27
摘要： The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diastereoisomeric mixture of an (±)-alpha-ethyl-2-oxo-l -pyrrolidine acetamide derivative.
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公开(公告)号：EP4402122A1
公开(公告)日：2024-07-24
申请号：EP22733028.9
申请日：2022-06-08
申请人： Zach System
IPC分类号： C07C231/24 , C07C237/06 , A61K31/165 , A61P25/16
CPC分类号： C07C231/24 , A61P25/16 , C07C237/06 , A61K31/165
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公开(公告)号：EP2475641A1
公开(公告)日：2012-07-18
申请号：EP10751938.1
申请日：2010-09-08
申请人： ZaCh System S.p.A.
发明人： CATOZZI, Nicola , COTARCA, Livius , FOLETTO, Johnny , FORCATO, Massimiliano , GIOVANETTI, Roberto , SORIATO, Giorgio , VERZINI, Massimo
IPC分类号： C07C209/74 , C07C211/30
CPC分类号： C07C211/30 , C07C209/74
摘要： A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I); i.e. Cinacalcet.HC1 and its intermediate of formula (IX).
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公开(公告)号：EP2766381A1
公开(公告)日：2014-08-20
申请号：EP12774995.0
申请日：2012-10-09
申请人： Zach System
发明人： DERRIEN, Yvon , POIRIER, Patricia , FORCATO, Massimiliano , PINTUS, Tony , COTARCA, Livius , MEUNIER, Sébastien , GRAINDORGE, Laurence
CPC分类号： C07J43/003 , C07J1/0059 , C07J31/003 , C07J31/006
摘要： The present invention relates to a process for the preparation of 17-substituted steroids and, more particularly, to an improved method of synthesizing abiraterone or derivatives thereof in high yield and purity by means of a key 3-formate intermediate.
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公开(公告)号：EP2398763A2
公开(公告)日：2011-12-28
申请号：EP10707243.1
申请日：2010-02-16
申请人： ZaCh System S.p.A.
发明人： CATOZZI, Nicola , COTARCA, Livius , FOLETTO, Johnny , FORCATO, Massimiliano , GIOVANETTI, Roberto , SORIATO, Giorgio , VERZINI, Massimo
IPC分类号： C07C209/68 , C07C209/70 , C07C211/62 , C07C221/00 , C07C303/24 , C07C305/18
CPC分类号： C07C209/70 , C07C211/28 , C07C211/30 , C07C221/00 , C07C303/28 , C07C305/12 , C07C225/16
摘要： A process for preparing N-[(1lR)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)- phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.
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公开(公告)号：EP2766381B1
公开(公告)日：2016-07-27
申请号：EP12774995.0
申请日：2012-10-09
申请人： Zach System
发明人： DERRIEN, Yvon , POIRIER, Patricia , FORCATO, Massimiliano , PINTUS, Tony , COTARCA, Livius , MEUNIER, Sébastien , GRAINDORGE, Laurence
CPC分类号： C07J43/003 , C07J1/0059 , C07J31/003 , C07J31/006
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公开(公告)号：EP2475641B1
公开(公告)日：2013-11-06
申请号：EP10751938.1
申请日：2010-09-08
申请人： ZaCh System S.p.A.
发明人： CATOZZI, Nicola , COTARCA, Livius , FOLETTO, Johnny , FORCATO, Massimiliano , GIOVANETTI, Roberto , SORIATO, Giorgio , VERZINI, Massimo
IPC分类号： C07C209/74 , C07C211/30
CPC分类号： C07C211/30 , C07C209/74
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公开(公告)号：EP2358659B1
公开(公告)日：2012-12-26
申请号：EP09753056.2
申请日：2009-10-16
申请人： ZaCh System S.p.A.
发明人： CATOZZI, Nicola , FOLETTO, Johnny , FORCATO, Massimiliano , GIOVANETTI, Roberto , SORIATO, Giorgio , VERZINI, Massimo
IPC分类号： C07C209/68 , C07C209/70 , C07C211/30 , C07C215/30 , C07C225/16
CPC分类号： C07C225/16 , C07B2200/07 , C07C209/68 , C07C211/30 , C07C215/30
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公开(公告)号：EP2358659A2
公开(公告)日：2011-08-24
申请号：EP09753056.2
申请日：2009-10-16
申请人： ZaCh System S.p.A.
发明人： CATOZZI, Nicola , FOLETTO, Johnny , FORCATO, Massimiliano , GIOVANETTI, Roberto , SORIATO, Giorgio , VERZINI, Massimo
IPC分类号： C07C209/68 , C07C209/70 , C07C211/30 , C07C215/30 , C07C225/16
CPC分类号： C07C225/16 , C07B2200/07 , C07C209/68 , C07C211/30 , C07C215/30
摘要： A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula (I) i.e. Cinacalcet and its intermediates of formulae (V), (Va) and (Vb).
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