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    PROCESS FOR PREPARING NEBIVOLOL
    3.
    发明授权
    PROCESS FOR PREPARING NEBIVOLOL 有权
    制备NEBIVOLOL的方法

    公开(公告)号：EP2102196B1

    公开(公告)日：2012-08-01

    申请号：EP07846784.2

    申请日：2007-11-23

    申请人： ZaCh System S.p.A.

    发明人： ULLUCCI, Elio ,  MARAGNI, Paolo ,  FOLETTO, Johnny ,  COTARCA, Livius

    IPC分类号： C07D407/04 ,  C07D311/58 ,  C07D311/22 ,  C07D407/12

    CPC分类号： C07D311/22 ,  C07D311/58 ,  C07D407/04

    摘要： The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.

    摘要翻译： 本发明涉及制备奈必洛尔的方法，并且更具体地涉及用于合成对映体富集的式（II）的6-氟苯并二氢吡喃醇或环氧化物衍生物的改进方法，其中R和X如说明书中所定义; 作为制备奈必洛尔的有用中间体。

    NEW PROCESS FOR THE SYNTHESIS OF ENEAMIDE DERIVATIVES
    6.
    发明授权
    NEW PROCESS FOR THE SYNTHESIS OF ENEAMIDE DERIVATIVES 有权
    新方法合成ENAMIDDERIVATEN的

    公开(公告)号：EP1716097B1

    公开(公告)日：2010-10-13

    申请号：EP04806523.9

    申请日：2004-12-22

    申请人： Zach System

    发明人： BURGOS, Alain ,  BERTRAND, Blandine ,  ROUSSIASSE, Sonia ,  PLUVIE, Jean-François ,  BLANCHET, Sylvie ,  MARTIN, Juliette ,  PERRIN, Florence ,  BOURDEAU, Françoise

    IPC分类号： C07C231/10 ,  C07C233/00

    CPC分类号： C07C231/10 ,  C07C233/06 ,  C07C2602/08 ,  C07C2602/10

    摘要： A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, -CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or -COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isanerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II) wherein R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO)mXwherein R4, m and X are as defined above

    Process for the preparation of levetiracetam
    8.
    发明公开
    Process for the preparation of levetiracetam 审中-公开
    Verfahren zur Herstellung von Levetiracetam

    公开(公告)号：EP2147911A1

    公开(公告)日：2010-01-27

    申请号：EP08425497.8

    申请日：2008-07-24

    申请人： ZaCh System S.p.A.

    发明人： Colli, Corrado ,  Forcato, Massimiliano ,  Cotarca, Livius

    IPC分类号： C07D207/273

    CPC分类号： C07D207/27

    摘要： A process for the manufacturing of levetiracetam, wherein said process comprises the steps of: (1) reacting the (-)-(S)-alpha-ethyl-2-oxo-1-pyrrolidine acetic acid with a substoichiometric amount of an activating agent in an alcoholic solvent, and (2) subjecting the resulting reaction solution of step (1) to an ammonolysis process with gaseous ammonia.

    摘要翻译： 制备左乙拉西坦的方法，其中所述方法包括以下步骤：（1）使（ - ） - （S）-α-乙基-2-氧代-1-吡咯烷乙酸与亚化学计量的活化剂 在醇溶剂中，和（2）使所得到的步骤（1）的反应溶液用氨气进行氨解反应。

    PROCESS FOR PREPARING DORZOLAMIDE
    10.
    发明授权
    PROCESS FOR PREPARING DORZOLAMIDE 有权
    制备多拉唑胺的方法

    公开(公告)号：EP2010544B1

    公开(公告)日：2009-08-05

    申请号：EP07728156.6

    申请日：2007-04-16

    申请人： ZaCh System S.p.A.

    发明人： MARAGNI, Paolo ,  MICHIELETTO, Ivan ,  COTARCA, Livius

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S) - (+) -10-camphorsulfonic acid so obtaining the (4S, 6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate) , and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.

    摘要翻译： （1S） - （+）-10-樟脑磺酸反应，通过选择性沉淀和回收其樟脑磺酸盐（多佐胺樟脑磺酸盐），得到（4S，6S）对映体， 并中和多佐胺樟脑磺酸盐以获得多佐胺。