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1.发明公开STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开STYRENYLDERIVATVERBINDUNGEN疾病和痛苦眼科的治疗
公开(公告)号：EP2076124A2
公开(公告)日：2009-07-08
申请号：EP08746483.0
申请日：2008-04-21
申请人： Acucela, Inc.
发明人： SCOTT, Ian, Leslie , KUKSA, Vladimir, Aleksandrovich , GALL, Anna , ORME, Mark, W. , GAGE, Jennifer , LITTLE, Thomas, L., Jr. , JIANG, Qin , ROSSITER, Lana, Michele , MCGEE, Kevin, F., Jr. , KUBOTA, Ryo
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：EP0000871B1
公开(公告)日：1981-02-11
申请号：EP78100508.7
申请日：1978-07-26
IPC分类号： C07C148/04 , C07C149/42
CPC分类号： C07C319/24 , C07C323/33
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3.发明公开STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS 审中-公开STYRENYLDERIVATVERBINDUNGENFÜRDIE BEHANDLUNG VON OPHTHALMOLOGISCHEN KRANKHEITEN UND LEIDEN
公开(公告)号：EP2076124A4
公开(公告)日：2011-08-03
申请号：EP08746483
申请日：2008-04-21
申请人： ACUCELA INC
发明人： SCOTT IAN LESLIE , KUKSA VLADIMIR ALEKSANDROVICH , GALL ANNA , ORME MARK W , GAGE JENNIFER , LITTLE THOMAS L JR , JIANG QIN , ROSSITER LANA MICHELE , MCGEE KEVIN F JR , KUBOTA RYO
IPC分类号： A01N33/02 , A61K31/135
CPC分类号： A61K31/5375 , A61K31/137 , A61K31/145 , A61K31/167 , A61K31/40 , A61K31/4453 , A61K31/495 , C07C211/27 , C07C211/28 , C07C211/29 , C07C215/08 , C07C215/30 , C07C215/42 , C07C215/46 , C07C217/10 , C07C217/16 , C07C217/18 , C07C217/48 , C07C217/54 , C07C217/62 , C07C217/72 , C07C225/06 , C07C225/18 , C07C233/05 , C07C237/04 , C07C317/28 , C07C323/25 , C07C323/32 , C07C323/33 , C07C2602/14 , C07C2602/16 , C07D207/06 , C07D211/14 , C07D295/03
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公开(公告)号：EP0000871A1
公开(公告)日：1979-03-07
申请号：EP78100508.7
申请日：1978-07-26
IPC分类号： C07C148/04 , C07C149/42
CPC分类号： C07C319/24 , C07C323/33
摘要： Method of preparing 2,2'-dithiodianiline by the steps of (A) obtaining an agitated mixture of a water solution of a salt of o-aminothiophenol and an unstable dispersion therein of a liquid hydrocarbon, (B) oxidizing said salt by the slow addition of a water soluble peroxide, (C) discontinuing the agitation to allow the formation of a sharply defined lower aqueous phase and upper hydrocarbon phase, (D) drawing off said lower aqueous phase and (E) distilling the hydrocarbon phase therefrom and recovering said 2,2'-dithiodianiline as a distilland
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公开(公告)号：EP3134080A1
公开(公告)日：2017-03-01
申请号：EP15721087.3
申请日：2015-04-23
发明人： HAUGHT, John, Christian , REILLY, Michael , HOKE, Steven, Hamilton , LEI, Qingxin , LIN, Yakang , SREEKRISHNA, Koti, Tatachar , TRABOULSI, Ashraf
IPC分类号： A61K31/167 , A61K8/42 , C07C35/12 , A61P43/00
CPC分类号： A61K31/165 , A23G4/06 , A23V2002/00 , A61K8/27 , A61K8/34 , A61K8/42 , A61K8/46 , A61K9/0014 , A61K9/0043 , A61K9/0078 , A61K9/06 , A61K9/28 , A61K31/09 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/4402 , A61K31/485 , A61K2800/244 , A61Q5/02 , A61Q5/12 , A61Q9/02 , A61Q11/00 , A61Q19/00 , C07C233/73 , C07C233/75 , C07C237/10 , C07C255/44 , C07C323/33
摘要： Personal care compositions, such as oral medication compositions containing a flavor system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.
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公开(公告)号：EP0036120B1
公开(公告)日：1983-02-09
申请号：EP81101477.8
申请日：1981-03-02
申请人： BAYER AG
IPC分类号： C07C149/42 , C07C148/00
CPC分类号： C07C319/24 , C07C323/33
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7.发明授权Alkoxyphenylpropylamines for the treatment of age-related macular degeneration 有权烷氧基Phenypropylaminen年龄相关性黄斑变性的治疗
公开(公告)号：EP2091955B1
公开(公告)日：2016-12-07
申请号：EP08832784.6
申请日：2008-10-03
申请人： Acucela, Inc.
发明人： SCOTT, Ian L. , KUKSA, Vladimir A. , ORME, Mark W. , LITTLE, Thomas , GALL, Anna , HONG, Feng
IPC分类号： C07C217/72 , A61K31/137 , A61P27/02
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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8.发明公开
公开(公告)号：EP2091955A4
公开(公告)日：2013-01-02
申请号：EP08832784
申请日：2008-10-03
申请人： ACUCELA INC
发明人： SCOTT IAN L , KUKSA VLADIMIR A , ORME MARK W , LITTLE THOMAS , GALL ANNA , HONG FENG
IPC分类号： C07C217/20 , A61K31/137 , A61K31/138 , A61K31/145 , A61K31/155 , A61P27/02 , C07C217/60 , C07C217/72 , C07C225/16 , C07C229/38 , C07C235/08 , C07C317/28 , C07D277/24 , C07D309/06
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和障碍，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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9.发明公开ALKOXY COMPOUNDS FOR DISEASE TREATMENT 有权烷氧基苯丙氨基酸zur Behandlung vonaltersabhängigenMakula-Degeneration
公开(公告)号：EP2091955A1
公开(公告)日：2009-08-26
申请号：EP08832784.6
申请日：2008-10-03
申请人： Acucela, Inc.
发明人： SCOTT, Ian L. , KUKSA, Vladimir A. , ORME, Mark W. , LITTLE, Thomas , GALL, Anna , HONG, Feng
IPC分类号： C07F5/00
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
摘要翻译： 本发明一般涉及用于治疗神经变性疾病和病症，特别是眼科疾病和病症的组合物和方法。 本文提供烷氧基衍生物化合物和包含这些化合物的药物组合物。 主题组合物可用于治疗和预防眼科疾病和障碍，包括年龄相关性黄斑变性（AMD）和斯塔尔加氏病。
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公开(公告)号：EP0036120A1
公开(公告)日：1981-09-23
申请号：EP81101477.8
申请日：1981-03-02
申请人： BAYER AG
IPC分类号： C07C149/42 , C07C148/00
CPC分类号： C07C319/24 , C07C323/33
摘要： Die Erfindung betrifft ein Verfahren zur Herstellung von Bis-(amino-phenyl)-disulfiden durch Umsetzung von Amino-thiophenolen mit Schwefel oder einer schwefelabgebenden Substanz. Hierbei wird in wäßriger Dispersion bei einer Temperatur von 10 bis 120°C und einem pH-Wert von 3 bis 9 gearbeitet.
摘要翻译： 本发明涉及一种用于通过使与硫或硫给体氨基苯硫酚的制备双（氨基苯基）二硫化物的方法。 这里，在水分散体在10至120℃的温度和pH为3至9的工作
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