Improved process for the catalytic synthesis of diaryl ethers
    7.
    发明公开
    Improved process for the catalytic synthesis of diaryl ethers 有权
    Verbeetes Verfahren zur katalytischen Herstellung von Diarylethern

    公开(公告)号:EP2065357A1

    公开(公告)日:2009-06-03

    申请号:EP08169219.6

    申请日:2008-11-17

    申请人: Saltigo GmbH

    IPC分类号: C07C41/16 C07C43/18

    摘要: Described is a process for preparing diaryl ethers of the formula (I)

             Ar-O-Ar'     (I)

    In which Ar is an aryl or substituted aryl group and Ar' is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group,
    by reacting an aryl of formula (II) or a aryloxy salt of formula (III)

             Ar-OH     (II)

             Ar-OR     (III)

    In which Ar has the same meaning as in formula (I) and R is an alkali metal,
    with an aryl or heteroaryl bromide of formula (IV)

             Ar'-Br     (IV)

    In which Ar' has the same meaning as in formula (I),
    characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

    摘要翻译: 描述了制备式(I)的二芳基醚的方法。ƒ€ƒ€ƒ€ƒ€ƒ€ƒAr-O-Ar'€ƒ€ƒ€ƒ€ƒ(I)In 其中Ar是芳基或取代的芳基,Ar'是芳基,取代的芳基,杂芳基或取代的杂芳基,通式(II)的芳基或式(III)的芳氧基盐反应€ƒ€ƒ€ ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ(II)€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ (III)其中Ar与式(I)中的含义相同,R为碱金属,与式(Ⅳ)的芳基或杂芳基溴化合物反应,ƒ€ƒ€ƒ€ƒ€ƒ (Ⅳ)其中Ar'与式(I)中的含义相同,其特征在于反应在铜的存在下进行 (I)盐和1-取代咪唑作为催化剂体系。