公开(公告)号：EP3307314A1

公开(公告)日：2018-04-18

申请号：EP16730773.5

申请日：2016-06-10

申请人： GlaxoSmithKline Biologicals S.A.

发明人： AMMENDOLA, Virginia ,  COLLOCA, Stefano ,  CORTESE, Riccardo ,  GRAZIOLI, Fabiana ,  NICOSIA, Alfredo ,  VITELLI, Alessandra

IPC分类号： A61K39/235 ,  C07K14/075 ,  C12N15/861 ,  A61K39/12 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K39/21 ,  A61K2039/5256 ,  C07K14/075 ,  C07K14/75 ,  C12N7/00 ,  C12N15/86 ,  C12N15/861 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10371 ,  C12N2740/16234 ,  C12N2760/18534

摘要： There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：EP3292142A1

公开(公告)日：2018-03-14

申请号：EP16722384.1

申请日：2016-05-04

申请人： VCN Biosciences SL

发明人： ALEMANY, Ramon ,  GIL, Raul ,  BAZÁN, Miriam

IPC分类号： C07K14/705 ,  C12N7/00 ,  A61K39/00 ,  A61K39/235

CPC分类号： A61K35/761 ,  A61K2039/57 ,  A61K2039/572 ,  A61P35/00 ,  C07K14/005 ,  C07K14/075 ,  C12N2710/10322 ,  C12N2710/10332

摘要： The present invention relates to oncolytic adenoviruses with functional deletions of immunodominant T-cell epitopes of adenovirus proteins, as well as to methods of using the oncolytic adenoviruses for the treatment of diseases, such as cancer. The oncolytic adenoviruses may also contain one or more heterologous nucleic acid sequences each encoding a tumor antigen or epitope. The oncolytic adenoviruses may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.

公开(公告)号：EP3364996A1

公开(公告)日：2018-08-29

申请号：EP16858324.3

申请日：2016-10-21

申请人： University Of Massachusetts Lowell

发明人： GAO, Guangping ,  AI, Jianzhong ,  LI, Hong ,  WEI, Qiang

IPC分类号： A61K38/17 ,  A61K48/00 ,  A61P35/00 ,  C07K14/005 ,  C07K14/075 ,  C07K14/47 ,  C12N15/63 ,  C12N5/10 ,  C12N15/861

CPC分类号： A61K48/0058 ,  A61K9/0019 ,  A61K9/0034 ,  A61K38/1709 ,  A61K48/00 ,  A61P35/00 ,  C07K14/005 ,  C07K14/075 ,  C07K14/47 ,  C12N5/10 ,  C12N15/86 ,  C12N2750/10041 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2840/007

摘要： The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).

公开(公告)号：EP3305798A1

公开(公告)日：2018-04-11

申请号：EP17191702.4

申请日：2011-12-09

申请人： The Trustees of The University of Pennsylvania

发明人： JUNE, Carl H. ,  LEVINE, Bruce L. ,  PORTER, David L. ,  KALOS, Michael D. ,  MILONE, Michael C.

IPC分类号： C07H21/04 ,  A61K39/00

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K38/177 ,  A61K38/1774 ,  A61K39/0011 ,  A61K39/39558 ,  A61K45/06 ,  A61K48/005 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/5256 ,  A61K2039/585 ,  C07K14/075 ,  C07K14/525 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/74 ,  C12N7/00 ,  C12N15/85 ,  C12N15/861 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2510/00 ,  C12N2740/15034 ,  C12N2740/15043 ,  C12N2740/15071 ,  A61K2300/00

摘要： The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

公开(公告)号：EP3280451A1

公开(公告)日：2018-02-14

申请号：EP16717228.7

申请日：2016-04-07

申请人： The United States Of America as Represented by the Secretary, Department of Health an Human Service

发明人： VENDITTI, Charles, P. ,  PAVAN, William, J. ,  CHANDLER, Randy

IPC分类号： A61K48/00 ,  A61P25/28 ,  C12N15/864

CPC分类号： A61K35/761 ,  A61K48/005 ,  A61P3/00 ,  A61P25/28 ,  C07K14/075 ,  C12N7/04 ,  C12N15/86 ,  C12N15/8616 ,  C12N2710/10022 ,  C12N2710/10034 ,  C12N2710/10045 ,  C12N2750/14143

摘要： Provided herein are compositions and methods for the viral gene therapy (e.g., AAV-directed gene therapy) of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.

公开(公告)号：EP2814513B1

公开(公告)日：2017-12-20

申请号：EP13749674.1

申请日：2013-02-13

申请人： The Regents of the University of California

发明人： HAMMOND, H., Kirk ,  GAO, Mei, Hua

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K38/16 ,  A61K9/08 ,  A61K9/06 ,  A61P17/00 ,  A61P9/00

CPC分类号： C12N15/861 ,  A61K31/436 ,  A61K31/65 ,  A61K38/2221 ,  A61K38/2228 ,  A61K38/2242 ,  A61K38/25 ,  A61K38/30 ,  A61K38/52 ,  A61K47/6901 ,  A61K48/00 ,  A61K48/005 ,  C07K14/075 ,  C07K14/57509 ,  C07K14/65 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2750/14143 ,  C12N2830/003

摘要： In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence; or an expression vehicle, a vector, a recombinant virus, or equivalent, having contained therein a paracrine-encoding nucleic acid or gene, and the expression vehicle, vector, recombinant virus, or equivalent can express the paracrine-encoding nucleic acid or gene in a cell or in vivo; and administering or delivering the paracrine polypeptide -encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence, or the expression vehicle, vector, recombinant virus, or equivalent, to an individual or a patient in need thereof, thereby treating, ameliorating or protecting (preventing) the individual or patient against the disease, infection or condition responsive to an increased paracrine polypeptide level.

公开(公告)号：EP4389760A1

公开(公告)日：2024-06-26

申请号：EP22858844.8

申请日：2022-08-21

申请人： Joint Stock Company "Biocad"

发明人： STRELKOVA, Anna Nikolaevna ,  SHUGAEVA, Tatiana Evgenievna ,  GERSHOVICH, Pavel Mikhailovich ,  IAKOVLEV, Pavel Andreevich ,  MOROZOV, Dmitry Valentinovich

IPC分类号： C07K14/075 ,  C07K14/005 ,  C12N15/861 ,  C12N7/01 ,  C12N15/09 ,  A61K48/00

CPC分类号： A61K48/00 ,  C07K14/075 ,  C07K14/005 ,  C12N7/00 ,  C12N15/09 ,  C12N15/861

摘要： The present application relates to the fields of gene therapy and molecular biology. More specifically, the present invention relates to an isolated modified capsid protein VP1 from adeno-associated virus serotype 9 (AAV9) comprising one or more amino acid substitutions compared to the wild-type AAV9 capsid protein VP1, which substitutions increase the efficiency of production (assembly) of the vector based on recombinant adeno-associated virus serotype 9 (rAAV9), to a capsid and a vector based on the above VP1, as well as to uses thereof.

公开(公告)号：EP3386527A1

公开(公告)日：2018-10-17

申请号：EP16873645.2

申请日：2016-12-05

申请人： The Regents of the University of California

发明人： MILLER, Yury ,  YAKSH, Tony L.

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61P25/02 ,  C07K14/47 ,  C07K14/515 ,  C07K16/18

CPC分类号： A61K48/0058 ,  A61K38/52 ,  A61P25/06 ,  A61P25/28 ,  A61P29/00 ,  C07K14/00 ,  C07K14/075 ,  C07K14/775 ,  C12N9/90 ,  C12N15/62 ,  C12N2750/14143 ,  C12Y501/99006

摘要： In alternative embodiments, provided are methods for increasing levels of and/or upregulating the expression of ApoA-I Binding Protein (APOA1BP, AIBP, or AI-BP) to treat, ameliorate, prevent, reverse, decrease the severity or duration of: a neuropathic pain, including an inflammation-induced neuropathic pain, a nerve or CNS inflammation, a, a post nerve injury pain, a post-surgical pain, a chemotherapeutic-induced peripheral neuropathy (CIPN) (e.g., cisplatin-induced allodynia) a neurodegeneration or neurodegenerative disease or condition, a migraine, and/or a hyperalgesia. In alternative embodiments, provided are methods comprising administering formulations and pharmaceutical compositions comprising an APOA1BP polypeptide or protein that is a human or a mammalian APOA1BP, or an AIBP1 or an AIBP2, or a recombinant, peptidomimetic or a synthetic APOA1BP, or a bioisostere of an ApoA-I Binding Protein to treat, ameliorate prevent, reverse, decrease the severity of a neuropathic pain, a TLR4-mediated allodynia and/or a hyperalgesia.

公开(公告)号：EP2649086B1

公开(公告)日：2017-07-19

申请号：EP11846757.0

申请日：2011-12-09

申请人： The Trustees of The University of Pennsylvania

发明人： JUNE, Carl, H. ,  LEVINE, Bruce, L. ,  PORTER, David, L. ,  KALOS, Michael, D. ,  MILONE, Michael C.

IPC分类号： A61K39/00 ,  A61K35/17

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K38/177 ,  A61K38/1774 ,  A61K39/0011 ,  A61K39/39558 ,  A61K45/06 ,  A61K48/005 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/5256 ,  A61K2039/585 ,  C07K14/075 ,  C07K14/525 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/80 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/74 ,  C12N7/00 ,  C12N15/85 ,  C12N15/861 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2510/00 ,  C12N2740/15034 ,  C12N2740/15043 ,  C12N2740/15071 ,  A61K2300/00

摘要： The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

摘要翻译： 本发明提供了用于治疗人类癌症的组合物和方法。 本发明涉及施用遗传修饰的T细胞以表达CAR，其中CAR包含抗原结合结构域，跨膜结构域，共刺激信号传导区和CD3ζ信号传导结构域。

公开(公告)号：EP2940128A1

公开(公告)日：2015-11-04

申请号：EP14382162.7

申请日：2014-04-30

申请人： Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) ,  Institut Català d'Oncologia (ICO)

发明人： Alemany Bonastre, Ramón ,  Rojas Expósito, Luis Alfonso

IPC分类号： C12N7/00 ,  C07K14/075

CPC分类号： C07K14/315 ,  A61K35/761 ,  A61K48/00 ,  C07K14/005 ,  C07K14/075 ,  C07K2319/00 ,  C07K2319/10 ,  C07K2319/31 ,  C07K2319/70 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2710/10371

摘要： The invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of the adenoviral hexon protein, pharmaceutical compositions containing it and its medical use. Particularly, the invention relates to an oncolytic adenovirus comprising a sequence encoding an albumin-binding moiety inserted in a hypervariable region (HVR) of the hexon protein coding sequence and its use in the prevention and/or treatment of cancer.

摘要翻译： 本发明涉及包含在腺病毒六邻体蛋白外表面上的白蛋白结合部分，含有它的药物组合物及其医疗用途的重组腺病毒。 特别地，本发明涉及包含编码插入六邻体蛋白编码序列的高变区（HVR）中的白蛋白结合部分的序列及其在预防和/或治疗癌症中的用途的溶瘤腺病毒。