公开(公告)号：EP3341471A2

公开(公告)日：2018-07-04

申请号：EP16839987.1

申请日：2016-08-23

申请人： White Dog Labs, Inc.

发明人： TRACY, Bryan P. ,  EYAL, Aharon M. ,  JONES, Shawn William ,  WIEDEL, Carrissa A.

IPC分类号： C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/52

CPC分类号： C12P7/28 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1029 ,  C12N9/1217 ,  C12P7/04 ,  C12Y101/01001 ,  C12Y102/0101 ,  C12Y102/01057 ,  C12Y102/07005 ,  C12Y203/01019 ,  C12Y207/02007

摘要： The present invention provides microorganisms capable of converting acetyl-coA into crotyl alcohol as well as fermentation methods for producing crotyl alcohol, either alone, or in combination with acetone and/or isopropanol. The microorganisms may be genetically engineered to express and/or disrupt one or more of the following enzymes: acetaldehyde dehydrogenase, alcohol dehydrogenase, bifunctional acetaldehyde/alcohol dehydrogenase, aldehyde oxidoreductase, phosphotransacetylase, acetate kinase, CoA-transferase A, CoA-transferase B, acetoacetate decarboxylase, secondary alcohol dehydrogenase, butyryl-CoA dehydrogenase (BCD), and/or trans-2-enoyl-CoA reductase (TER).

公开(公告)号：EP2773761A1

公开(公告)日：2014-09-10

申请号：EP12845783.5

申请日：2012-11-02

申请人： Easel Biotechnologies, LLC

发明人： CHO, Kwang Myung ,  HIGASHIDE, Wendy ,  LEE, Chrissie ,  RABIZADEH, Shahrooz

IPC分类号： C12N15/52 ,  C12N15/70 ,  C12P7/24

CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/24 ,  C12Y101/01157 ,  C12Y102/01057 ,  C12Y103/01086 ,  C12Y203/01009

摘要： Microorganisms and methods of producing n-butyraldehyde with enhanced yields are presented in which a microorganism is engineered to enhance the conversion of a carbon source into n-butyraldehyde. The n-butyraldehyde is recovered by way of a gas stripping process that occurs during the conversion process, providing significantly greater product yield than post-fermentation recovery of n-butyraldehyde alone.

公开(公告)号：EP3262179A4

公开(公告)日：2018-07-11

申请号：EP16756175

申请日：2016-02-23

申请人： BIOCHEMINSIGHTS INC

发明人： DODDS DAVID R ,  ARMIGER WILLIAM B ,  KOFFAS MATTHEOS

IPC分类号： C12P1/00 ,  C12M1/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12P7/16 ,  C25B3/04 ,  C25B9/08 ,  C25B15/02 ,  C25B15/08

CPC分类号： C12P7/16 ,  C12M45/07 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01027 ,  C12Y101/01157 ,  C12Y102/0101 ,  C12Y102/01046 ,  C12Y102/01057 ,  C12Y102/04001 ,  C12Y103/01006 ,  C12Y103/01038 ,  C12Y203/01008 ,  C12Y203/01009 ,  C12Y203/01054 ,  C12Y401/02043 ,  C12Y503/01027 ,  C25B3/04 ,  C25B9/08 ,  C25B15/02 ,  C25B15/08 ,  Y02E50/10

摘要： A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency.

公开(公告)号：EP3262179A1

公开(公告)日：2018-01-03

申请号：EP16756175.2

申请日：2016-02-23

申请人： Biocheminsights Inc.

发明人： DODDS, David R. ,  ARMIGER, William B. ,  KOFFAS, Mattheos

IPC分类号： C12P1/00 ,  C12P7/16

CPC分类号： C12P7/16 ,  C12M45/07 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01027 ,  C12Y101/01157 ,  C12Y102/0101 ,  C12Y102/01046 ,  C12Y102/01057 ,  C12Y102/04001 ,  C12Y103/01006 ,  C12Y103/01038 ,  C12Y203/01008 ,  C12Y203/01009 ,  C12Y203/01054 ,  C12Y401/02043 ,  C12Y503/01027 ,  C25B3/04 ,  C25B9/08 ,  C25B15/02 ,  C25B15/08 ,  Y02E50/10

摘要： A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency.

公开(公告)号：EP2773761A4

公开(公告)日：2015-06-17

申请号：EP12845783

申请日：2012-11-02

申请人： EASEL BIOTECHNOLOGIES LLC

发明人： CHO KWANG MYUNG ,  HIGASHIDE WENDY ,  LEE CHRISSIE ,  RABIZADEH SHAHROOZ

IPC分类号： C12N15/52 ,  C12N15/70 ,  C12P7/16 ,  C12P7/24

CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N15/52 ,  C12P7/24 ,  C12Y101/01157 ,  C12Y102/01057 ,  C12Y103/01086 ,  C12Y203/01009

摘要： Microorganisms and methods of producing n-butyraldehyde with enhanced yields are presented in which a microorganism is engineered to enhance the conversion of a carbon source into n-butyraldehyde. The n-butyraldehyde is recovered by way of a gas stripping process that occurs during the conversion process, providing significantly greater product yield than post-fermentation recovery of n-butyraldehyde alone.

摘要翻译： 提出了微生物和产率提高的正丁醛的方法，其中将微生物工程化以增强碳源向正丁醛的转化。 正丁醛通过在转化过程中发生的气体脱除方法回收，与单独的正丁醛的发酵后回收相比提供了显着更大的产物产率。