公开(公告)号：EP1091924B1

公开(公告)日：2010-06-16

申请号：EP99916424.7

申请日：1999-04-06

申请人： THE UAB RESEARCH FOUNDATION

发明人： BROUILLETTE, Wayne, J. ,  MUCCIO, Donald, D.

IPC分类号： C07C63/04 ,  C07C63/33 ,  C07C63/36 ,  C07C229/44 ,  A61K31/195

CPC分类号： C07C235/38 ,  C07B2200/09 ,  C07C51/09 ,  C07C61/35 ,  C07C61/39 ,  C07C62/34 ,  C07C233/55 ,  C07C403/18 ,  C07C403/20 ,  C07C2601/16 ,  C07C2602/10 ,  C07C57/46

公开(公告)号：EP1432784A1

公开(公告)日：2004-06-30

申请号：EP02798177.8

申请日：2002-09-10

申请人： THE PROCTER & GAMBLE COMPANY

发明人： DYKSTRA, Robert, Richard ,  GRAY, Lon, Montgomery

IPC分类号： C11D3/50 ,  A61K7/32 ,  C07C229/44

CPC分类号： C11D3/001 ,  A61K8/37 ,  A61K2800/57 ,  A61Q13/00 ,  C07C69/732 ,  C07C69/734 ,  C11D3/50 ,  C11D3/507

摘要： The present invention relates to photo-labile pro-fragrances, as well as a fragrance raw material delivery system comprising: i) from about 0.001% to about 100% by weight, of a photo-labile pro-fragrance compound having the formula (I) wherein OR is a unit derived from a fragrance raw material alcohol, HOR; R1 is one or more electron donating groups; each R2 is independently hydrogen, C¿1?-C12 alkyl, and mixtures thereof; X is selected from the group consisting of -OH, -NH2, -NHR?3¿, and mixtures thereof; R3 is hydrogen, C¿1?-C12 linear or branched alkyl, C6-C10 aryl, and mixtures thereof; and ii) optionally from about 0.001% to about 50% by weight, of one or more fragrance raw materials.

公开(公告)号：EP0883598B1

公开(公告)日：2003-08-20

申请号：EP97903318.0

申请日：1997-02-19

申请人： Henkel Kommanditgesellschaft auf Aktien

发明人： ROSE, David ,  HÖFFKES, Horst ,  MEINIGKE, Bernd

IPC分类号： C07C215/80 ,  C07C217/84 ,  C07C229/44 ,  A61K7/13

CPC分类号： A61Q5/10 ,  A61K8/415 ,  C07C215/80 ,  C07C217/84 ,  C07C229/44 ,  D06P1/32 ,  D06P3/08

摘要： Described are aminophenol derivatives of general formula (I) in which one of the two groups R and R is hydrogen and the other is hydrogen, chlorine or fluorine; one of the two groups R and R is hydrogen, a C1-4-alkoxy group, a C1-4-alkyl group, a C1-4-hydroxyalkyl group, preferably with a terminal hydroxy group or halogen and the other is one of the groups: -O-CH2-CH=CH2, -CH=CH-COOX in which X is hydrogen or a physiologically tolerable inorganic or organic cation and, in the case when the group concerned is R , the group (a) and, in the case when the group concerned is R , (b), in which -A- in each case is one of the groups -(CH2)x- in which x = 1 to 4, -O-(CH2)y-O- in which y = 1 to 4, -O-(CnH2n-z(OH)z)-O- in which n = 1 to 10 and z = 1 or, when n is greater than or equal to 3, z = 2, -O-(C2H4-O)u- in which u = 1 to 4 and -O-(C3H6-O)v- in which v is 1 to 4. Such derivatives are particularly suitable for use as developers in oxidative dyes for dyeing keratin fibres. Brilliant hues with a high degree of fastness are obtained with the usual coupling agents, particularly when dyeing hair.

公开(公告)号：EP0489836B1

公开(公告)日：1994-12-21

申请号：EP90913585.7

申请日：1990-08-27

申请人： DUKE UNIVERSITY

发明人： PORTER, Ned, A. ,  BRUHNKE, John, D.

IPC分类号： C12N13/00 ,  C12N9/68 ,  C12N9/70 ,  C12N9/74 ,  C12N9/76 ,  C07C205/43 ,  C07C205/56 ,  C07C229/44 ,  C07C257/18

CPC分类号： C12N9/6429 ,  C07C205/43 ,  C07C205/56 ,  C07C229/44 ,  C07C257/18 ,  C12N9/00 ,  C12N9/50 ,  C12N13/00 ,  C12Y304/21005

摘要： Light activated acyl-enzymes of formula (III) are disclosed. In the compounds of formula (III) ENZ is an enzyme, X is O or S, Y is -NR3R4, -OR5, or -SR5, and Z is a nucleophile; m is 0 to 3 and n is 1 or 2; Y is substituted on the ring at either or both of the 4 and 6 position. R1 and R2 are each independently H, C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl. R3 and R4 are each independently H, C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl, except that R3 and R4 are not simultaneously both H. R5 is C1 to C4 alkyl, C3 to C4 unconjugated alkenyl, or C3 to C4 unconjugated alkynyl. Methods of using the acyl-enzymes and intermediates for making the acyl-enzymes are disclosed. A preferred intermediate is 2-propenoic acid, 3-(2-hydroxy-4-diethylaminophenyl)-2-methyl-, 4-(aminoiminomethyl)phenyl ester, (E)-, monohydrochloride salt, which is preferably reacted with thrombin to form an acyl-thrombin.

公开(公告)号：EP0323631B1

公开(公告)日：1993-08-11

申请号：EP88121773.1

申请日：1988-12-28

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Yamamoto, Takanori ,  Furuta, Akihiro ,  Konishi, Shinji ,  Hioki, Takeshi ,  Hanawa, Ryotaro ,  Tomioka, Jun

IPC分类号： C07C255/36 ,  C07F19/00 ,  C07C237/16 ,  C07C229/44 ,  G03F7/00

CPC分类号： C07C229/44 ,  C07C255/34 ,  C07C255/42 ,  C07C309/14 ,  C07C311/05 ,  C07C317/48 ,  C07F7/1856 ,  G03F7/0226 ,  G03F7/091 ,  Y10S430/127

公开(公告)号：EP0307103A3

公开(公告)日：1991-04-17

申请号：EP88307746.3

申请日：1988-08-22

申请人： ZENECA LIMITED

发明人： Anthony, Vivienne Margaret ,  Heaney, Stephen Paul ,  Beautement, Kevin ,  Clough, John Martin ,  Crowley, Patrick Jelf ,  Godfrey, Christopher Richard Ayles ,  de Fraine, Paul John ,  Buckley, Alan John ,  Hutchings, Michael Gordon ,  Ferguson, Ian

IPC分类号： C07C69/736 ,  C07C323/62 ,  C07C315/00 ,  C07C229/44 ,  C07C69/72 ,  C07C381/00 ,  C07C309/63 ,  C07C67/327 ,  A01N37/38 ,  A01N41/10

CPC分类号： C07D213/64 ,  A01N37/38 ,  A01N37/40 ,  A01N41/04 ,  A01N41/06 ,  A01N41/10 ,  A01N43/10 ,  A01N43/20 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/653 ,  A01N43/66 ,  A01N43/74 ,  A01N43/90 ,  A01N47/20 ,  A01N57/24 ,  C07C45/59 ,  C07C205/35 ,  C07C205/37 ,  C07C205/38 ,  C07C205/52 ,  C07C217/92 ,  C07C233/25 ,  C07C233/75 ,  C07C235/56 ,  C07C245/08 ,  C07C251/24 ,  C07C251/48 ,  C07C255/54 ,  C07C271/28 ,  C07C311/29 ,  C07C317/22 ,  C07C323/20 ,  C07C327/16 ,  C07D207/34 ,  C07D213/643 ,  C07D213/65 ,  C07D213/68 ,  C07D213/74 ,  C07D213/85 ,  C07D213/89 ,  C07D215/227 ,  C07D215/36 ,  C07D231/12 ,  C07D233/56 ,  C07D237/14 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D241/18 ,  C07D241/44 ,  C07D249/08 ,  C07D251/26 ,  C07D263/58 ,  C07D277/24 ,  C07D277/68 ,  C07D333/56 ,  C07D495/04 ,  C07F9/5456 ,  C07C47/575

摘要： Fungicidal compounds of the formula (I) :
and stereoisomers thereof, wherein K is oxygen or sulphur; Z is optionally substituted aryl or optionally substituted heteroaryl; X is 0, S(O) n , NR 4 , CR'R 2 , CHR S , CO, CR'(OR 2 ), C=CR 1 R 2 , CHR 1 CHR 2 , CR' =C R 2 , CHR 1 CR 2 =CH, C-C, OCHR', CHR'O, OCHR'O, S(O) n CHR', S(O) n CHR'O, CHR'S(0) n , CHR 1 OSO 2 , NR 4 CHR 1 , CHR 1 NR 4 , C0 2 , 0 2 C, S0 2 0, OSO 2 , CO.CO, COCHR', COCHR'O, CHR'CO, CHOH.CHR 1 , CHR'.CHOH,
CONR 4 , OCONR 4 , NR 4 CO, CSNR 4 , OCS.NR4, SCO.NR 4 , NR 4 CO 2 , NR 4 CS, NR 4 CSO, NR4COS, NR4CONR4, S(O) n NR 4 , NR 4 S(O) n , CS 2 , S 2 C, CO.S, SCO, N=N, N=CR 1 , CR 1 =N, CHR 1 CHR 2 CH(OH), CHR'OCO, CHR'SCO, CHR 1 NR 4 CO, CHR'NR 4 COR 4 , CHR'CHR 2 CO, O.N=CR', CHR 1 O.N=CR 2 , CO.OCR'R 2 , CHR'CHR 2 CHR 3 , OCHR 1 CHR 2 , (CH 2 ) m O, CHR 1 OCHR 2 , CHR'CHR 2 0, OCHR'CHR 2 0, S(O)- n CHR 1 CHR 1 , CHR 1 S(O) n CHR 2 , CHR'CHR 2 S(O) n . CR 1 =NNR 4 . NR 4 N=CR 1 , CHR 1 CONR 2 , CHR 1 OCO.NR 2 , CH=CHCH 2 O, COCHR 1 CHR 2 O or (R 5 ) 2 P + CHR 2 Q-; A, B and E, which may be the same or different, are H, hydroxy, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl, phenoxy, nitro or cyano; R', R 2 and R 3 , which may be the same or different, are H, C 1-4 alkyl or phenyl; R 4 is H, C 1-4 alkyl or COR'; R 5 is optionally substituted phenyl; Q- is a halide anion; n is 0, 1 or 2 and m is a 3, 4 or 5; except that when Z is unsubstituted phenyl and X and K are oxygen, A, B and E are not all hydrogen.

公开(公告)号：EP0263229A1

公开(公告)日：1988-04-13

申请号：EP87101109.4

申请日：1987-01-27

申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.

发明人： Hashimoto, Kinji ,  Goto, Kiyoto ,  Kanai, Ken-ichi ,  Tsuda, Yoshiaki

IPC分类号： C07C215/74 ,  C07C229/42 ,  C07C229/54 ,  C07C229/44 ,  C07D295/18 ,  C07C217/78 ,  C07C225/22 ,  C07C233/77 ,  C07C233/34 ,  C07C311/01 ,  C07C237/16

CPC分类号： C07D295/185 ,  C07C255/00 ,  C07C311/16 ,  C07C311/38 ,  C07C317/34 ,  C07C323/63 ,  C07D295/192

摘要： Disclosed are phenol derivatives of the formula
wherein R' is a substituted phenyl group, R 2 and R 3 are C 1 -C 6 alkyl group and of the formula
wherein R 8 , R 9 and R 1c are C 1 -C 6 alkyl and the like and A is H, C 1 -C 6 alkylsulfonyl and the like substituents. These compounds and some related compounds have anti-inflammatory activity and lipoxygenase inhibitory activity.

摘要翻译： 公开了式CHEM的苯酚衍生物，其中R 1是取代的苯基，R 2和R 3是C 1 -C 6烷基和式CHEM的化合物，其中R 8，R R 9和R 10是C 1 -C 6烷基等，A是H，C 1 -C 6烷基磺酰基等取代基。 这些化合物和一些相关化合物具有抗炎活性和脂氧合酶抑制活性。

公开(公告)号：EP0262305A1

公开(公告)日：1988-04-06

申请号：EP87108676.5

申请日：1987-06-16

申请人： AMERICAN CYANAMID COMPANY

发明人： Maulding, Donald Roy

IPC分类号： C07C229/44 ,  C07D215/54 ,  C07C69/716

CPC分类号： C07D215/48 ,  C07D215/54

摘要： The present invention relates to novel methods for the preparation of quinoline-2,3-dicarboxylic acid, useful for the preparation of the highly effective 2-(2imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.

摘要翻译： 本发明涉及用于制备高效2-（2咪唑啉-2-基）喹啉-3-羧酸除草剂的喹啉-2,3-二羧酸的新方法。

公开(公告)号：EP3044216A2

公开(公告)日：2016-07-20

申请号：EP14761747.6

申请日：2014-08-20

申请人： University of Washington through its Center for Commercialization ,  University of Montana ,  Guilloteau, Nicolas

发明人： BUTTRICK, Brian ,  GUILLOTEAU, Nicolas ,  DIAZ, Philippe ,  ISOHERRANEN, Nina

IPC分类号： C07D317/30 ,  C07C69/616 ,  C07C69/73 ,  C07C69/734 ,  C07D339/06 ,  C07C317/44 ,  C07C317/46 ,  C07C323/62 ,  C07C229/42 ,  C07C229/44 ,  C07C57/50 ,  C07C59/54 ,  C07C59/72 ,  C07C59/86 ,  A61K31/357 ,  A61K31/385 ,  A61K31/216

CPC分类号： C07D317/30 ,  C07C57/50 ,  C07C59/54 ,  C07C59/72 ,  C07C59/86 ,  C07C69/616 ,  C07C69/73 ,  C07C69/734 ,  C07C69/738 ,  C07C229/42 ,  C07C229/44 ,  C07C317/44 ,  C07C323/62 ,  C07C323/65 ,  C07C2602/10 ,  C07C2602/28 ,  C07C2603/74 ,  C07D339/06

摘要： The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated retinoic acid metabolism. The compositions comprise compounds of formula (I). A repreid50000060307390 IB/345 nullsents aryl optionally substituted with one, two, three, or four groups that are each independently halogen, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy; X is a bond, —CH2—, —CHR5—, —C═CHR4—, —NR4—, —N═O—R4—, —O—, —S—, —SO—, —SO2—, —C(O)—, or —C(NR4)—, or X is of formula (a), (b) or (c), wherein each n is independently 1, 2, or 3; each R4 is independently hydrogen or C1-6 alkyl; R5 is independently hydrogen, C1-6 alkyl, or —OR6, where R6 is selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyL C3-12 cycloalkyl, heterocyclyl, aryl, arylC1-6 alkyl, heteroaryl, or heteroarylC1-6 alkyl; Y is C1-6 alkylene, C2-6 alkenylene, or C2-6 alkylylene moiety.

摘要翻译： 本公开一般涉及用于治疗通过抑制CYP26介导的视黄酸代谢而改善的疾病的组合物和方法。 组合物包含式（I）的化合物。 氰基，硝基，C 1-6烷基，C 1-6卤代烷基，-NH 2，-NH（C 1 -C 6烷基）取代的芳基任选被一个，两个，三个或四个基团取代的IB / ，-N（C 1 -C 6烷基）2，-OH，C 1 -C 6烷氧基和C 1 -C 6卤代烷氧基; X是键，-CH 2 - ， - CHR 5 - ， - C = CHR 4 - ， - NR 4 - ， - N = O-R 4 - ， - O - ， - S - ， - SO - ， - SO 2 - O） - 或-C（NR 4） - 或X为式（a），（b）或（c）的化合物，其中每个n独立地为1,2或3; 每个R 4独立地是氢或C 1-6烷基; R5独立地为氢，C1-6烷基或-OR6，其中R6选自氢，C1-6烷基，C2-6烯基，C2-6炔基C3-12环烷基，杂环基，芳基，芳基C1- 6烷基，杂芳基或杂芳基C 1-6烷基; Y是C 1-6亚烷基，C 2-6亚烯基或C 2-6亚烷基部分。

公开(公告)号：EP2261299B1

公开(公告)日：2016-01-06

申请号：EP10010702.8

申请日：2005-02-17

申请人： E. I. du Pont de Nemours and Company

发明人： Herron, Norman ,  Johansson, Gary A. ,  Radu, Nora Sabina

IPC分类号： H05B33/14 ,  C08G73/02 ,  C07C229/44 ,  H01L51/00 ,  H01L51/50 ,  C09K11/06

CPC分类号： H01L51/0035 ,  C07C229/44 ,  C08G73/026 ,  C09K11/06 ,  C09K2211/1014 ,  C09K2211/1408 ,  H01L51/004 ,  H01L51/0059 ,  H01L51/5012 ,  H01L51/5048 ,  H05B33/14 ,  Y02E10/549