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公开(公告)号：EP2855419B1
公开(公告)日：2017-03-01
申请号：EP13725649.1
申请日：2013-05-27
IPC分类号： C07C67/31 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/277 , A61K31/335 , A61K31/38 , A61K31/395 , A61P3/10 , C07C235/20 , C07C235/42 , C07C255/54 , C07C317/18 , C07C317/20 , C07C62/34 , C07C67/347 , C07C69/757
CPC分类号： A61K31/425 , A61K31/192 , A61K31/277 , A61K31/341 , A61K31/382 , A61K31/397 , A61K31/40 , A61K31/416 , A61K31/4196 , A61K45/06 , C07C61/39 , C07C62/34 , C07C67/31 , C07C67/347 , C07C69/757 , C07C235/20 , C07C235/42 , C07C235/68 , C07C255/54 , C07C317/18 , C07C317/20 , C07C317/46 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D207/48 , C07D209/08 , C07D213/30 , C07D213/84 , C07D215/14 , C07D217/02 , C07D231/56 , C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D275/02 , C07D307/20 , C07D309/12 , C07D333/38 , C07D335/02
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公开(公告)号：EP2855419A1
公开(公告)日：2015-04-08
申请号：EP13725649.1
申请日：2013-05-27
IPC分类号： C07C67/31 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/277 , A61K31/335 , A61K31/38 , A61K31/395 , A61P3/10 , C07C235/20 , C07C235/42 , C07C255/54 , C07C317/18 , C07C317/20 , C07C62/34 , C07C67/347 , C07C69/757
CPC分类号： A61K31/425 , A61K31/192 , A61K31/277 , A61K31/341 , A61K31/382 , A61K31/397 , A61K31/40 , A61K31/416 , A61K31/4196 , A61K45/06 , C07C61/39 , C07C62/34 , C07C67/31 , C07C67/347 , C07C69/757 , C07C235/20 , C07C235/42 , C07C235/68 , C07C255/54 , C07C317/18 , C07C317/20 , C07C317/46 , C07C2601/02 , C07C2602/08 , C07D205/04 , C07D207/48 , C07D209/08 , C07D213/30 , C07D213/84 , C07D215/14 , C07D217/02 , C07D231/56 , C07D233/64 , C07D249/08 , C07D257/04 , C07D263/32 , C07D275/02 , C07D307/20 , C07D309/12 , C07D333/38 , C07D335/02
摘要： The present invention relates to compounds of general formula I, (I) wherein the groups R
1 , R
2 , R
3 , m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.摘要翻译： 本发明涉及通式（I）的化合物，其中基团R 1，R 2，R 3，m和n如权利要求1中所定义，其具有有价值的药理学性质，特别是与GPR40受体的结合和 调节其活性。 该化合物适用于治疗和预防可受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。此外，本发明涉及用于合成式I化合物的新型中间体。
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3.发明公开Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors 审中-公开Cyclische 11-β-羟基类固醇脱氢酶 - Hemmer vom Typ I
公开(公告)号：EP2527317A1
公开(公告)日：2012-11-28
申请号：EP12181050.1
申请日：2007-08-23
IPC分类号： C07C61/39 , C07C61/40 , C07D203/18 , C07D205/04 , C07D205/08 , C07D263/04 , C07D263/30 , C07D317/72 , C07D493/08 , C07D295/185 , C07C62/38 , C07D451/02 , C07C57/00 , C07C59/00
CPC分类号： C07C61/40 , C07B2200/07 , C07C57/50 , C07C57/62 , C07C59/54 , C07C59/56 , C07C59/72 , C07C59/88 , C07C61/39 , C07C62/38 , C07C2603/66 , C07C2603/74 , C07D203/18 , C07D205/04 , C07D205/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/42 , C07D211/46 , C07D213/40 , C07D217/02 , C07D241/08 , C07D257/04 , C07D261/02 , C07D261/08 , C07D263/04 , C07D277/04 , C07D277/46 , C07D277/64 , C07D277/82 , C07D285/135 , C07D295/185 , C07D295/205 , C07D401/12 , C07D403/04 , C07D407/06 , C07D413/04 , C07D471/04 , C07D493/08
摘要： Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure:
enantiomers, diastereomers, solvates, or salts thereof, wherein A, W, X and Z are defined herein.摘要翻译： 提供了新的化合物，它是11-β-羟基类固醇脱氢酶I型抑制剂。 11-β-羟基类固醇脱氢酶I型抑制剂可用于治疗，预防或减缓需要11-β-羟基类固醇脱氢酶I型抑制剂治疗的疾病进展。 这些新化合物具有以下结构：其中A，W，X和Z如本文所定义，其对映异构体，非对映异构体，溶剂合物或其盐。
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公开(公告)号：EP2427416A4
公开(公告)日：2012-10-03
申请号：EP10771933
申请日：2010-05-03
发明人： ZACHARIE BOULOS , PENNEY CHRISTOPHER , GAGNON LYNE , BIENVENU JEAN-FRANCOIS , PERRON VALERIE , GROUIX BRIGITTE
IPC分类号： C07C57/30 , A61K31/192 , A61K31/41 , A61K31/44 , A61P13/12 , A61P29/00 , C07C57/58 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
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公开(公告)号：EP1565421B1
公开(公告)日：2008-07-23
申请号：EP03758601.3
申请日：2003-11-07
申请人： Pfizer Products Inc.
CPC分类号： C07C253/30 , C07C51/08 , C07C2602/08 , C07C61/39 , C07C255/47 , C07C61/29
摘要： A method for preparing indan-1,3-dicarboxylic acid compounds which are useful intermediates in the syntheses of aryl fused azapolycyclic compounds as agents for the treatment of neurological and psychological disorders.
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公开(公告)号：EP1476150A4
公开(公告)日：2007-07-04
申请号：EP03709252
申请日：2003-02-20
申请人： UNIV WASHINGTON
发明人： DUGAN LAURA L , LOVETT EVA G , QUICK KEVIN L , HARDT JOSHUA I
IPC分类号： A61K45/00 , A61K31/19 , A61K31/194 , A61P39/06 , A61P43/00 , C01B31/02 , C07C61/39 , B01J20/22 , C07C309/00
CPC分类号： B82Y30/00 , A61K31/19 , B82Y40/00 , C01B32/15 , C01B32/152 , C07C61/39 , C07C2604/00
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公开(公告)号：EP1070039A1
公开(公告)日：2001-01-24
申请号：EP99916376.9
申请日：1999-04-05
申请人： MERCK & CO., INC.
发明人： LI, Jing , TSCHAEN, David, M. , SONG, Zhiguo , ZHAO, Mangzu
IPC分类号： C07C51/16
CPC分类号： C07C201/12 , C07C51/29 , C07C227/02 , C07C2601/02 , C07D263/56 , C07D498/04 , C07C205/57 , C07C271/22 , C07C63/06 , C07C57/32 , C07C59/64 , C07C57/42 , C07C61/39
摘要： The present invention relates to the oxidation of a primary alcohol of Formula (II) to the carboxylic acid of Formula (I): R1CH2OH→R1CO2H.
摘要翻译： 本发明涉及将式（II）的伯醇氧化为式（I）的羧酸：R 1 CH 2 OH} R 1 CO 2 H。
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公开(公告)号：EP0571870B1
公开(公告)日：1998-08-19
申请号：EP93108044.4
申请日：1993-05-17
申请人： BAYER AG
发明人： Mittendorf, Joachim, Dr. , Kunisch, Franz, Dr. , Matzke, Michael, Dr. , Militzer, Hans-Christian, Dr. , Endermann, Rainer, Dr. , Metzger, Karl Georg, Dr. , Bremm, Klaus-Dieter, Dr. , Plempel, Manfred, Dr.
IPC分类号： C07C229/48 , C07C271/24 , C07C271/36 , C07C271/20 , C07C237/04 , C07C239/18 , A61K31/195 , A61K31/215
CPC分类号： C07C61/35 , C07C61/15 , C07C61/20 , C07C61/39 , C07C61/40 , C07C69/74 , C07C69/753 , C07C69/757 , C07C229/48 , C07C237/04 , C07C251/42 , C07C271/22 , C07C271/24 , C07C271/34 , C07C271/36 , C07C2601/08 , C07C2601/10 , C07C2603/18 , C07D265/12 , C07D307/93 , Y02P20/55
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公开(公告)号：EP0806410A2
公开(公告)日：1997-11-12
申请号：EP97303043.0
申请日：1997-05-02
IPC分类号： C07C69/757 , C07C69/753 , C07C251/44 , C07C61/39 , C07C229/08 , C07C271/22 , C07C237/36
CPC分类号： C07C69/00 , C07C61/39 , C07C229/08 , C07C237/12 , C07C251/44 , C07C271/22 , C07C2603/00 , C07C2603/26
摘要： The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
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公开(公告)号：EP0799185A1
公开(公告)日：1997-10-08
申请号：EP95938251.0
申请日：1995-10-10
CPC分类号： C07C61/39 , C07C43/253 , C07C61/40 , C07C217/74 , C07C2601/08 , C07C2601/14
摘要： This invention relates to certain 1,3,3-(trisubstituted)cyclohexane dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
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