公开(公告)号：EP4305018A2

公开(公告)日：2024-01-17

申请号：EP22712763.6

申请日：2022-03-09

申请人： Amgen Inc.

发明人： CAILLE, Sebastien ,  MURRAY, James ,  QUASDORF, Kyle ,  NGUYEN, Hannah ,  SILVA ELIPE, Maria Victoria ,  ERICSON, Ari Elizabeth

IPC分类号： C07C201/10 ,  C07C205/12

公开(公告)号：EP3594199A1

公开(公告)日：2020-01-15

申请号：EP18182368.3

申请日：2018-07-09

申请人： F.I.S.- Fabbrica Italiana Sintetici S.p.A.

发明人： Brasola, Elena ,  Di Silvestro, Marco

IPC分类号： C07C205/12 ,  C07D213/75

摘要： The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I):

and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula (II):

or salts thereof by means of the crystalline 2-fluoro-3-nitrotoluene.

公开(公告)号：EP3500551A1

公开(公告)日：2019-06-26

申请号：EP16913709.8

申请日：2016-08-22

申请人： BASF SE

发明人： XU, Xiaoming ,  HUANG, Chao ,  FRASSETTO, Timo

IPC分类号： C07C205/12 ,  C07F9/50

公开(公告)号：EP3015451B1

公开(公告)日：2018-01-17

申请号：EP14817123.4

申请日：2014-06-03

申请人： Kumiai Chemical Industry Co., Ltd.

发明人： IKUMI, Akiko ,  NAKAMURA, Takayuki

IPC分类号： C07C205/12 ,  C07C205/58 ,  C07B61/00 ,  C07C201/10

CPC分类号： C07C201/10 ,  C07C205/58 ,  C07C205/12

摘要： The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general formula (1): (in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom, etc.; and R 5 represents a halogen atom or alkoxy carbonyl group), the method including the following processes: (i) a process for reacting aniline compounds of general formula (2): (in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as previously defined.) in the presence of a metal salt of nitrous acid and an acid, and (ii) a process for reacting the product of process (i) in the presence of a metal salt of nitrous acid and a copper compound; and the total amount of water used in process (ii) being 1.2-2.2 L (liters) with respect to one mole of the compound of general formula (2).

公开(公告)号：EP3015451A4

公开(公告)日：2017-03-01

申请号：EP14817123

申请日：2014-06-03

申请人： IHARA CHEMICAL IND CO

发明人： IKUMI AKIKO ,  NAKAMURA TAKAYUKI

IPC分类号： C07C205/12 ,  C07B61/00 ,  C07C201/10 ,  C07C205/58

CPC分类号： C07C201/10 ,  C07C205/58 ,  C07C205/12

摘要： The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general formula (1): (in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom, etc.; and R 5 represents a halogen atom or alkoxy carbonyl group), the method including the following processes: (i) a process for reacting aniline compounds of general formula (2): (in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as previously defined.) in the presence of a metal salt of nitrous acid and an acid, and (ii) a process for reacting the product of process (i) in the presence of a metal salt of nitrous acid and a copper compound; and the total amount of water used in process (ii) being 1.2-2.2 L (liters) with respect to one mole of the compound of general formula (2).

公开(公告)号：EP2940002B1

公开(公告)日：2016-12-14

申请号：EP13869658.8

申请日：2013-12-20

申请人： Nippon Soda Co., Ltd.

发明人： INOUE, Hiroki ,  SAKATA, Yuzuru ,  KOBAYASHI, Shinichi ,  ITO, Yoshikazu ,  KITAYAMA, Takashi

IPC分类号： C07C211/52 ,  C07C17/12 ,  C07C25/13 ,  C07C201/08 ,  C07C205/12 ,  C07C209/36 ,  C07C209/74

CPC分类号： C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

摘要： The present invention provides a halogenated aniline represented by formula (I) (wherein each of X 1 and X 2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

公开(公告)号：EP2473476B1

公开(公告)日：2015-01-14

申请号：EP10745569.3

申请日：2010-08-18

申请人： Bayer Intellectual Property GmbH

发明人： MORADI, Wahed Ahmed ,  LUI, Norbert ,  DOCKNER, Michael ,  JAGUSCH, Thomas

IPC分类号： C07C201/12 ,  C07C209/68 ,  C07C205/06 ,  C07C205/12 ,  C07C231/12 ,  C07F5/02 ,  C07C233/15

CPC分类号： C07F5/027 ,  C07C231/12 ,  C07C233/15

公开(公告)号：EP2513034B1

公开(公告)日：2014-07-30

申请号：EP10788085.8

申请日：2010-12-13

申请人： BASF SE

发明人： FRITZ, Rüdiger ,  HEMPEL, Renate ,  ZÖLLINGER, Michael ,  MERTEN, Anne-Kathrin ,  ZSCHIESCHANG, Doris ,  HOMANN, Ina ,  GERSDORF, Annett ,  ALLARDT, Holger ,  REETZ, Reiner ,  FLEGEL, Elvira

IPC分类号： C07C201/08 ,  C07C205/06 ,  C07C205/12

CPC分类号： C07C201/16 ,  C07C205/06 ,  C07C205/12

公开(公告)号：EP1698606B1

公开(公告)日：2013-02-20

申请号：EP04808022.0

申请日：2004-12-21

申请人： Sumitomo Chemical Company, Limited

发明人： HAGIYA, Koji

IPC分类号： C07C17/20 ,  C07C17/093 ,  C07C19/08 ,  C07C22/08 ,  C07C205/12 ,  C07D233/58 ,  C07D213/61 ,  C07B39/00 ,  C07D233/56 ,  C07D233/64

CPC分类号： C07D233/64 ,  C07B39/00 ,  C07C17/093 ,  C07C17/202 ,  C07C201/12 ,  C07D213/61 ,  C07D233/56 ,  C07C19/08 ,  C07C22/08 ,  C07C205/12

公开(公告)号：EP2192087A4

公开(公告)日：2012-05-02

申请号：EP08828723

申请日：2008-08-27

申请人： SUMITOMO CHEMICAL CO

发明人： HAGIYA KOJI

IPC分类号： C01D3/02 ,  C07B39/00 ,  C07C17/20 ,  C07C22/08 ,  C07C51/00 ,  C07C51/58 ,  C07C51/60 ,  C07C63/72 ,  C07C67/14 ,  C07C69/82 ,  C07C201/12 ,  C07C205/11 ,  C07C205/12

CPC分类号： C07B39/00 ,  C01D3/02 ,  C07C17/208 ,  C07C51/00 ,  C07C51/58 ,  C07C51/60 ,  C07C67/14 ,  C07C201/12 ,  C07C63/30 ,  C07C69/76 ,  C07C205/12