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    SURFACE ACTIVE COMPOUND
    3.
    发明公开
    SURFACE ACTIVE COMPOUND 审中-公开

    公开(公告)号：EP3530646A1

    公开(公告)日：2019-08-28

    申请号：EP18158400.4

    申请日：2018-02-23

    申请人： Koninklijke Coöperatie Cosun U.A.

    发明人： RANOUX, Adeline ,  RAAIJMAKERS, Harry ,  LAZEROMS, Robert ,  VAN DER KLIS, Fritz ,  VAN ES, Daan

    IPC分类号： C07C229/12 ,  C07C235/12 ,  C11D1/52 ,  C11D1/90

    摘要： The present invention relates to surface active compounds based on polyhydroxy acids. The compounds are of formula (I), where X represents hydrogen or a cation; n is 2, 3 or 4 and Y represents a group of formula (II) or formula (III), wherein at least one of R1, R2 and R3 is a surfactant tail group, and are generally easy to prepare by derivatization of polyhydroxy acids obtained from renewable resources such as, in particular, parenchymal plant materials. The invention relates to the surface active compounds, compositions comprising the same, methods of production and different uses of the surface active compounds.

    BETA-AMINO ACID COMPRISING ELECTROLYTE AND METHOD FOR THE DEPOSITION OF A METAL LAYER
    7.
    发明公开
    BETA-AMINO ACID COMPRISING ELECTROLYTE AND METHOD FOR THE DEPOSITION OF A METAL LAYER 审中-公开
    BETA-AMINOSUREURE MIT ELEKTROLYT UND VERFAHREN ZUR ABLAGERUNG EINER METALLSCHICHT

    公开(公告)号：EP2449148A2

    公开(公告)日：2012-05-09

    申请号：EP10730685.4

    申请日：2010-07-06

    申请人： Enthone, Inc.

    发明人： STARK, Franz-Josef ,  WERNER, Christoph

    IPC分类号： C23C18/31 ,  C23C18/36 ,  C07C231/02 ,  C07C235/12 ,  C23C18/50

    CPC分类号： C23C18/44 ,  C07C229/08 ,  C07C229/12 ,  C07C229/16 ,  C07C229/22 ,  C07C237/06 ,  C07C309/14 ,  C23C18/1601 ,  C23C18/31 ,  C23C18/32 ,  C23C18/34 ,  C23C18/36 ,  C23C18/38 ,  C23C18/40 ,  C23C18/42 ,  C23C18/48 ,  C23C18/50

    摘要： The present invention relates to an electrolyte for the electroless deposition of a metal layer on a substrate, wherein the electrolyte is free of heavy metal stabilizers, cyanides, selenium compounds and sulfur compounds comprising sulfur in an oxidation state between −2 and +5, and in which instead a &bgr;-amino acid is used as stabilizer. In particular, the inventive electrolyte can comprise 3-aminopropionic acid, 3-aminobutyric acid, 3-amino-4-methylvaleric acid, and 2-aminoethane-sulfonic acid. Furthermore, the invention is directed to a method for the electroless deposition of metal layers utilizing an inventive electrolyte as well as the use of &bgr;-amino acids as stabilizer in electrolytes for the electroless deposition of metal layers in general.

    摘要翻译： 本发明涉及用于在基材上无电沉积金属层的电解质，其中电解质不含重金属稳定剂，氰化物，硒化合物和包含-2和+5之间氧化态的硫的硫化合物，和 在其中代替使用一种氨基酸作为稳定剂。 特别地，本发明的电解质可以包含3-氨基丙酸，3-氨基丁酸，3-氨基-4-甲基戊酸和2-氨基乙磺酸。 此外，本发明涉及一种利用本发明电解质的金属层的无电沉积方法，以及在电解质中用作金属层的无电沉积的电解质中的“ - 氨基酸”作为稳定剂的方法。

    ALPHA-HYDROXY AMIDES AS BRADYKININ ANTAGONISTS OR INVERSE AGONISTS
    8.
    发明授权
    ALPHA-HYDROXY AMIDES AS BRADYKININ ANTAGONISTS OR INVERSE AGONISTS 有权
    ALPHA-羟基酰胺阿拉伯胶原蛋白

    公开(公告)号：EP1706372B1

    公开(公告)日：2010-05-19

    申请号：EP04814829.0

    申请日：2004-12-17

    申请人： Merck Sharp & Dohme Corp.

    发明人： WOOD, Michael, R. ,  ANTHONY, Neville, J. ,  BOCK, Mark, G. ,  KUDUK, Scott, D.

    IPC分类号： C07C235/40 ,  C07D271/06 ,  C07C235/12 ,  C07C235/34 ,  C07C235/26 ,  C07C235/06 ,  C07C23/08 ,  C07D213/61 ,  A61K31/235 ,  A61K31/4245 ,  A61K31/165 ,  A61K31/44 ,  A61P29/00

    CPC分类号： C07D239/26 ,  C07C235/06 ,  C07C235/08 ,  C07C235/12 ,  C07C235/26 ,  C07C235/34 ,  C07C235/40 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/18 ,  C07D209/12 ,  C07D213/56 ,  C07D213/61 ,  C07D257/04 ,  C07D271/06 ,  C07D275/06 ,  C07D401/10 ,  C07D413/10

    摘要： α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a group selected from Ra. (2) (CH2)nNRbC(O)Ra. (3)(CH2)nNRbSO2Rd.(4)(CH2)nNRbCO2Ra.(5)(CH2)k-heterocycle optionally substituted with 1 to 3 groups independently selected from halogen.nitro, cyano.ORa.SRa.C1-4 alkyl and C1-3 haloakyl wherein said heterocycle is (a) a 5-membered heteroaromatic ring having a ring heteroatom selected from N.O and S. and optionally having up to 3 additional ring nitrogen atoms wherein said ring is optionally benzo-fused; or(b) a 6-membered heteromatic ring containing from 1 to 3 ring nitrogen atoms and N-oxydes thereof. Wherein said ring is optionally benzo-fused. (6)(CH2)kCO2Ra.and (7)(CH2)C(O)NRbRc. R2b is OH or a group selected from R2a; or R2a and R2b together with the carbon atom to which they are attached form a 3-to 7-membered carbocyclic ring optionally substituted with 1 to 4 groups independently selected from halogen. ORa. C1-4 alkyl and C1-4 haloalkyl;

    摘要翻译： 通式（I）的α-羟基酰胺衍生物是缓激肽B1拮抗剂或反激动剂，其可用于治疗或预防与缓激肽B1途径相关的疼痛和炎症等症状。 R2a选自（1）选自Ra的基团。 （2）（CH2）nNRbC（O）Ra。 （3）（CH2）nNRbSO2Rd。 （4）（CH2）nNRbCO2Ra。 （5）（CH2）k-杂环，其任选地被1至3个独立地选自卤素，硝基，氰基，硫代C 1-4烷基和C 1-3卤代烷基的基团取代，其中所述杂环是（a）5元杂芳族 环，其具有选自NO和S的环杂原子，并且任选地具有至多3个另外的环氮原子，其中所述环任选地被苯并稠合; 或（b）含有1至3个环氮原子的6-元杂环和其N-氧化物。 其中所述环任选地被苯并稠合。 （6）（CH2）kCO2Ra。 和（7）（CH 2）C（O）NR b R c。 R2b是OH或选自R2a的基团; 或R 2a和R 2b与它们所连接的碳原子一起形成任选被1至4个独立地选自卤素的基团取代的3至7元碳环。 ORA。 C 1-4烷基和C 1-4卤代烷基。

    PROCEDE DE SYNTHESE DE COMPOSES DE TYPE CERAMIDE
    10.
    发明授权
    PROCEDE DE SYNTHESE DE COMPOSES DE TYPE CERAMIDE 有权
    方法合成神经酰胺化合物

    公开(公告)号：EP1644318B1

    公开(公告)日：2008-05-07

    申请号：EP04767243.1

    申请日：2004-06-03

    申请人： Société La Biochimie Appliquée SA (Solabia)

    发明人： LASSALLE, Laurent ,  YVERGNAUX, Florent

    IPC分类号： C07C231/02 ,  C07C235/02 ,  C07C235/12 ,  C12P13/02

    CPC分类号： A61K31/164 ,  A61K8/68 ,  A61Q5/00 ,  A61Q19/08 ,  C07C233/18 ,  C07C233/20 ,  C07C235/08 ,  C12P13/02

    摘要： The invention relates to the fields of fatty substance chemistry, specifically of the ceramide-type compound synthesis. The invention resides substantially in the synthesis of ceramide-type compounds. Specifically, the aim of the invention is a new enzymatic synthesis method, comprising at least one amidification step and one esterification step, achieved through lipases, among fatty acids and/or esters thereof and amino alcohols. The resulting ceramide-type compounds can be used as cosmetic and/or pharmaceutical compositions, in particular as dermatological compositions in conjunction or in admixture with one or more suitable cosmetic and/or pharmaceutical excipients or carriers. The method has an interest particularly in the synthesis of active compounds useful in the fields of cosmetology and/or pharmacology and specifically of dermatology.