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1.发明公开ACETYL SALICYCLIC ACID DIMERS, SYNTHESIS THEREOF, AND USES THEREOF TO PREVENT AND TREAT COMPLEMENT-MEDIATED DISORDERS 审中-公开ACETYLSALICYLSÄUREDIMERE，其合成和用途及其用于预防和疾病治疗补体介导
公开(公告)号：EP3071543A1
公开(公告)日：2016-09-28
申请号：EP14862004.0
申请日：2014-11-17
申请人： Aurin Biotech Inc.
IPC分类号： C07C69/12 , A61K31/616 , A61P37/02
CPC分类号： C07C69/16 , A61K8/375 , A61K9/0014 , A61Q5/006 , A61Q7/00 , A61Q19/004 , A61Q19/008 , C07C69/017 , Y02A50/411
摘要： Dimers of acetyl salicylic acid, including 4,4′-diacetoxy-[1,1′-biphenyl]-3,3′-dicarboxylic acid (DAS-1) and 5,5′-methylenebis(2-acetoxybenzoic acid) (DAS-2) are provided. Methods of blocking the C3 convertase stage of the alternative complement pathway, preventing formation of the membrane attack complex of complement, and preventing or treating a complement-mediated disorder in a mammal including the step of administering dimers of acetyl salicylic acid are also provided.
摘要翻译： 乙酰水杨酸的二聚体，包括4,4'-二乙酰氧基 - [1,1'-联苯] -3,3'-二羧酸（DAS-1）和5,5'-亚甲基双（2-乙酰氧基苯甲酸）（DAS -2）被提供。 因此提供阻断补体旁路途径的C3转化阶段，防止形成补体的膜攻击复合物，以及预防或治疗哺乳动物包括投乙酰水杨酸的二聚体的步骤的补体介导的病症的方法。
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2.发明公开
公开(公告)号：EP2231579A1
公开(公告)日：2010-09-29
申请号：EP08864514.8
申请日：2008-12-16
申请人： BP Chemicals Limited
摘要： A process for the manufacture of at least one of acetic acid and methyl acetate by the carbonylation of methanol, dimethyl ether and/or dimethyl carbonate with carbon monoxide in the presence of a zeolite catalyst of structure type MOR having a crystal size of no greater than about 3 microns.
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公开(公告)号：EP1813586A1
公开(公告)日：2007-08-01
申请号：EP05807059.0
申请日：2005-11-17
IPC分类号： C07C27/00 , C07C27/12 , C07C29/50 , C07C37/58 , C07C39/04 , C07C63/06 , C07C67/39 , C07C69/04 , C07C69/12 , C07C69/54 , C07C69/78 , C07B61/00 , B01J23/44
CPC分类号： C07C67/40 , B01J21/08 , B01J21/18 , B01J23/44 , B01J23/628 , B01J31/121 , B01J2231/70 , C07B41/00 , C07C27/12 , C07C29/50 , C07C45/33 , C07C45/38 , C07C45/39 , C07C67/39 , C07C69/54 , C07C69/14 , C07C69/06
摘要： The present invention provides a method for oxidizing a hydrocarbon, an alcohol or an aldehyde, which comprises: oxidizing a hydrocarbon, an alcohol or an aldehyde to an alcohol, an aldehyde, a carboxylic acid or a carboxylate ester corresponding thereto, in a liquid phase having: a region in which oxygen is substantially present; and a region in which oxygen is substantially absent, in the presence of a catalyst containing a palladium, wherein the region in which oxygen is substantially absent is 0.1 to 10% by volume with respect to a total of the region in which oxygen is substantially present and the region in which oxygen is substantially absent.
摘要翻译： 本发明提供了一种用于氧化烃，醇或醛的方法，其包括：将烃，醇或醛氧化成液相中的醇，醛，羧酸或与其对应的羧酸酯 具有：基本上存在氧的区域; 以及在含有钯的催化剂的存在下，基本上不存在氧的区域，其中基本上不存在氧的区域相对于基本上存在氧的区域的总和为0.1-10体积％ 和氧基本上不存在的区域。
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公开(公告)号：EP1254658A4
公开(公告)日：2003-06-18
申请号：EP01946787
申请日：2001-01-26
申请人： TAKARA BIO INC
发明人： OHNOGI HIROMU , SHIRAGA MASAHIRO , KOBAYASHI EIJI , LI TUO-PING , DEGUCHI SUZU , NISHIYAMA EIJI , SAGAWA HIROAKI , KATO IKUNOSHIN
IPC分类号： A23L1/30 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352 , A61K31/7004 , A61P9/10 , A61P25/00 , A61P25/28 , A61P43/00 , C07C49/255 , C07C49/573 , C07C49/83 , C07C49/84 , C07C69/12
CPC分类号： A61K31/7004 , A23L33/10 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352
摘要： Remedies or preventives for diseases with a need for the enhancement of the production of nerve growth factor which contain as the active ingredient specific compounds having an activity of enhancing the production of nerve growth factor or salts thereof, agents for enhancing the production of nerve growth factor, or foods, drinks or feeds for enhancing the production of nerve growth factor; a method of enhancing the production of nerve growth factor which comprises administering the above compounds or salts thereof to mammals; and use of the above compounds or salts thereof in remedies or preventives for diseases with a need for the enhancement of the production of nerve growth factor, agents for enhancing the production of nerve growth factor, or foods, drinks or feeds for enhancing the production of nerve growth factor. Also, novel compounds having an activity of enhancing the production of nerve growth factor are provided.
摘要翻译： 需要增强神经生长因子产生的疾病的治疗或预防措施，所述神经生长因子包含作为活性成分的具有增强神经生长因子或其盐生产活性的特定化合物，用于增强神经生长因子 ，或用于增强神经生长因子产生的食物，饮料或饲料; 一种增强神经生长因子产生的方法，该方法包括给予哺乳动物上述化合物或其盐; 以及将上述化合物或其盐应用于需要增强神经生长因子产生的疾病的治疗或预防，用于增强神经生长因子产生的药剂或用于增强产生神经生长因子的食品，饮料或饲料 神经生长因子。 此外，还提供了具有增强神经生长因子产生活性的新型化合物。
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5.发明公开Aryl-substituted naphthalene, benzoxepine, benzazepine and benzocycloheptene derivatives 失效亚芳基取代的萘磺酸，苯并吡喃，苯并吖庚因和苄基胆碱衍生物
公开(公告)号：EP0291327A3
公开(公告)日：1989-01-25
申请号：EP88304354.9
申请日：1988-05-13
申请人： SCHERING CORPORATION
IPC分类号： C07C49/755 , C07C49/747 , C07C49/757 , C07C125/077 , C07C131/00 , C07C109/16 , C07C133/02 , C07C93/14 , C07C103/38 , C07C69/12 , C07C69/757
CPC分类号： C07D223/16 , C07C43/21 , C07C43/215 , C07C43/23 , C07C45/00 , C07C45/292 , C07C45/46 , C07C45/511 , C07C45/512 , C07C45/513 , C07C45/516 , C07C45/62 , C07C45/64 , C07C45/65 , C07C45/66 , C07C45/68 , C07C45/69 , C07C49/747 , C07C49/755 , C07C49/757 , C07C49/84 , C07D313/08 , C07D317/72 , C07D339/06 , C07C47/277
摘要： Certain aryl substituted naphthalene, benzoxepine, benzazepine and benzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation.
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公开(公告)号：EP3404061B1
公开(公告)日：2020-02-19
申请号：EP17866675.6
申请日：2017-10-30
申请人： LG Chem, Ltd.
发明人： KIM, Hyun Kyu , MOON, Jeong Ju , KIM, Joo Ho , LEE, Mi Yeon
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公开(公告)号：EP3071543B1
公开(公告)日：2019-10-02
申请号：EP14862004.0
申请日：2014-11-17
申请人： Aurin Biotech Inc.
IPC分类号： C07C69/12 , A61K31/616 , A61P37/02 , A61K8/37 , A61Q5/00 , A61Q7/00 , A61Q19/00 , A61K9/00 , C07C69/017 , C07C69/16
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8.发明授权PRODRUGS OF CANNABIDIOL, COMPOSITIONS COMPRISING PRODRUGS OF CANNABIDIOL AND METHODS OF USING THE SAME 有权大麻的PRODGRUGS，大麻二酚的组合物PRODGRUGS及使用方法
公开(公告)号：EP2176208B1
公开(公告)日：2015-01-21
申请号：EP08796904.4
申请日：2008-07-30
发明人： STINCHCOMB, Audra, Lynn , GOLINSKI, Miroslaw, Jerzy , HOWARD, Jeffery, Lynn , HAMMELL, Dana, Carmel , BANKS, Stan, Lee
IPC分类号： C07C47/277 , C07C69/12 , C07C69/675 , C07C69/708 , C07C69/96 , C07C219/04 , C07C229/12 , C07C271/44 , C07C271/52 , C07C69/017 , C07C69/68 , C07C39/23 , A61K31/215 , A61K31/265 , A61K31/27 , A61P25/04 , A61P29/00 , A61P1/08
CPC分类号： C07C39/23 , C07C69/017 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/96 , C07C219/04 , C07C229/12 , C07C271/44 , C07C271/52 , C07C2601/16
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公开(公告)号：EP1254658B1
公开(公告)日：2008-09-24
申请号：EP01946787.7
申请日：2001-01-26
申请人： TAKARA BIO INC.
发明人： OHNOGI, Hiromu , SHIRAGA, Masahiro , KOBAYASHI, Eiji , LI, Tuo-Ping , DEGUCHI, Suzu , NISHIYAMA, Eiji , SAGAWA, Hiroaki , KATO, Ikunoshin
IPC分类号： A61K31/12 , A61K31/216 , A61K31/352 , A61K31/7004 , A61P25/00 , A61P25/28 , A61P9/10 , A61P43/00 , A23L1/30 , C07C49/83 , C07C49/255 , C07C49/84 , C07C49/573 , C07C69/12
CPC分类号： A61K31/7004 , A23L33/10 , A61K31/12 , A61K31/216 , A61K31/222 , A61K31/352
摘要： Remedies or preventives for diseases with a need for the enhancement of the production of nerve growth factor which contain as the active ingredient specific compounds having an activity of enhancing the production of nerve growth factor or salts thereof, agents for enhancing the production of nerve growth factor, or foods, drinks or feeds for enhancing the production of nerve growth factor; a method of enhancing the production of nerve growth factor which comprises administering the above compounds or salts thereof to mammals; and use of the above compounds or salts thereof in remedies or preventives for diseases with a need for the enhancement of the production of nerve growth factor, agents for enhancing the production of nerve growth factor, or foods, drinks or feeds for enhancing the production of nerve growth factor. Also, novel compounds having an activity of enhancing the production of nerve growth factor are provided.
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