公开(公告)号：EP4034544B1

公开(公告)日：2023-11-15

申请号：EP20776230.3

申请日：2020-09-04

发明人： ROSCOE, Stephen B. ,  BONILLA, Tonya D. ,  GRIESGRABER, George W.

IPC分类号： C07H17/075 ,  A61L2/28 ,  C12M1/34 ,  C12Q1/22

公开(公告)号：EP3897620A1

公开(公告)日：2021-10-27

申请号：EP19899606.8

申请日：2019-12-20

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： BOLLYKY, Paul L. ,  NAGY, Nadine ,  KABER, Gernot

IPC分类号： A61K31/37 ,  A61K31/7048 ,  C07H17/075

公开(公告)号：EP3149212B1

公开(公告)日：2020-08-26

申请号：EP15799039.1

申请日：2015-06-01

申请人： Georgia State University Research Foundation, Inc.

发明人： IYER, Suri Saranathan ,  DHAWANE, Abasaheb ,  HE, Yun ,  ZHANG, Xiaohu ,  DINH, Hieu ,  VASIREDDI, Mugdha ,  SWEENEY, Joyce

IPC分类号： C07H3/04 ,  C07H15/04 ,  C07H15/18 ,  C07H17/075 ,  C12Q1/34 ,  G01N27/327

公开(公告)号：EP3130596A1

公开(公告)日：2017-02-15

申请号：EP15776849.0

申请日：2015-04-06

申请人： Hirosaki University

发明人： YAMADA, Katsuya ,  SASAKI, Ayako ,  TESHIMA, Tadashi ,  YAMAMOTO, Toshihiro ,  OTSUKA, Yuji

IPC分类号： C07H17/075 ,  A61K49/00 ,  C07H17/02 ,  G01N21/78 ,  G01N33/48 ,  G01N33/58

CPC分类号： G01N33/66 ,  A61K49/0002 ,  A61K49/0021 ,  A61K49/0039 ,  A61K49/0052 ,  A61K51/0491 ,  C07H17/02 ,  C07H17/075 ,  C07H19/04 ,  G01N33/574 ,  G01N33/582

摘要： A purpose of the present invention is to provide a novel glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Another purpose of the present invention is to provide an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Yet another purpose of the present invention is to provide a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. The present invention provides D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1) - (G4) below.

摘要翻译： 本发明的目的是提供一种新的葡萄糖衍生物，其通过膜糖输送系统摄入细胞并由式（1）表示。 本发明的另一个目的是提供使用所述葡萄糖衍生物的细胞或细胞内分子的成像剂和成像方法。 本发明的另一个目的是提供使用所述方法中使用的所述葡萄糖衍生物和成像剂以高精度检测癌细胞的方法。 本发明提供D-葡萄糖衍生物和L-葡萄糖衍生物，其中葡萄糖与荧光分子基团的7-位与香豆素骨架或喹诺酮骨架结合。 还提供了使用该衍生物的细胞成像剂和成像方法。 还提供了使用L-葡萄糖衍生物的癌细胞显像剂和成像方法。 G是选自下式（G1） - （G4）的基团。

公开(公告)号：EP2385950B1

公开(公告)日：2014-03-12

申请号：EP10729677.4

申请日：2010-01-12

申请人： University of Washington

发明人： GELB, Michael, H. ,  BLANCHARD, Sophie

IPC分类号： C07H13/04 ,  C07H17/075

CPC分类号： C07H17/075 ,  C07H1/00 ,  C07H13/04

公开(公告)号：EP2385950A4

公开(公告)日：2012-07-18

申请号：EP10729677

申请日：2010-01-12

申请人： UNIV WASHINGTON

发明人： GELB MICHAEL H ,  BLANCHARD SOPHIE

IPC分类号： C07H13/04 ,  C07H17/075

CPC分类号： C07H17/075 ,  C07H1/00 ,  C07H13/04

公开(公告)号：EP1204671B1

公开(公告)日：2003-12-03

申请号：EP00953743.2

申请日：2000-07-28

申请人： 3M Innovative Properties Company

发明人： BENTSEN, James, G. ,  MICKLESON, Christopher, A. ,  KNUDSON, Orlin, B. ,  LEWANDOWSKI, Kevin, M.

IPC分类号： C07H17/075 ,  C07D409/04 ,  C07D407/04 ,  C12Q1/22 ,  G01N33/58

CPC分类号： C07H17/075 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q2334/20 ,  G01N2333/924

摘要： Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when cleaved by target enzymes. Preferred compounds include sugar and peptide derivatives of umbelliferone derivatives bearing a heterocyclic five membered ring at the 3-position. These compounds can be used for rapidly detecting food pathogens and for determining sterilization effectiveness. The compounds may also be used in a form bounded to a polymeric support or to a biomolecule or macromolecule.

公开(公告)号：EP1045856B1

公开(公告)日：2003-04-09

申请号：EP99900500.2

申请日：1999-01-07

申请人： Aventis Pharma S.A.

发明人： HAESSLEIN, Jean-Luc ,  KLICH, Michel ,  LAURIN, Patrick ,  MUSICKI, Branislav ,  PERIERS, Anne-Marie

IPC分类号： C07H17/075 ,  A61K31/70

CPC分类号： C07H17/075

公开(公告)号：EP0888371B1

公开(公告)日：2002-05-22

申请号：EP97940823.4

申请日：1997-09-05

申请人： Oklahoma Medical Research Foundation

发明人： LIAV, Avraham ,  HANSJERGEN, Joyce Anne ,  SHIMASAKI, Craig, David

IPC分类号： C07H17/075 ,  C07H15/203 ,  C12Q1/34

CPC分类号： C07H7/027 ,  C12Q1/34 ,  C12Q2334/50 ,  G01N33/56983 ,  G01N2333/924

摘要： Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of general formula (I) are provided wherein R1 and R2 are alkyl groups containing 1 to 4 carbon atoms and R3 is a chromogenic or fluorogenic group. These substrates can be used to detect influenza types A and B in clinical samples or specimens. More particularly, these 4,7-dialkoxy-N-acetylneuraminic acid substrates can be used to distinguish between various viruses having neuraminidase reactivity. Thus, influenza type A and B viruses can be distinguished from parainfluenza type 1, 2, 3 and 4, and mumps using the 4,7-dialkoxy-N-acetylneuraminic acid derivatives of this invention. Diagnostic methods employing these substrates are provided to identify influenza type A and B viruses in clinical specimens and to distinguish from other viruses having neuraminidase reactivity.

公开(公告)号：EP0502827A1

公开(公告)日：1992-09-09

申请号：EP92810176.5

申请日：1992-03-06

申请人： NIPPON ZOKI PHARMACEUTICAL CO., LTD.

发明人： Okamoto, Kaoru, c/o Inst. of Bio-Active Science ,  Morita, Shinji, c/o Inst. of Bio-Active Science

IPC分类号： C07H15/04 ,  C07H19/06 ,  C07H17/075 ,  C07J17/00 ,  A61K31/70

CPC分类号： C07H13/04 ,  C07H3/04 ,  C07H15/04 ,  C07H15/10 ,  C07H19/06 ,  C07H19/16 ,  C07J41/0055

摘要： Sialic acid derivatives are disclosed having a group represented by the formula (I):

   wherein X is hydrogen, a lower alkyl group or benzyl, Y is hydrogen or acetyl, Ac is acetyl, and the wavy lines indicate that the compounds of formula (I) include both the α-anomer and the β-anomer,
and pharmaceutically acceptable salts thereof. The sialic acid derivatives have excellent chemical and enzymatical stability. The compounds are useful for the treatment of central or peripheral nervous diseses.

摘要翻译： 公开了具有由式（I）表示的基团的唾液酸衍生物：其中X是氢，低级烷基或苄基，Y是氢或乙酰基，Ac是乙酰基，波浪线表示式 ）包括α-端基异构体和β-端基异构体及其药学上可接受的盐。 唾液酸衍生物具有优异的化学和酶学稳定性。 该化合物可用于治疗中枢或周围神经病。