公开(公告)号：EP4423282A2

公开(公告)日：2024-09-04

申请号：EP22888434.2

申请日：2022-10-25

申请人： Purdue Research Foundation ,  Doudareva, Natalia ,  Huang, Xing-Qi

发明人： DOUDAREVA, Natalia ,  HUANG, Xing-Qi

IPC分类号： C12N15/52 ,  C12N15/86 ,  C12P7/24

CPC分类号： C12P7/24 ,  C12N9/0004 ,  C12N15/8242 ,  C07K14/415

公开(公告)号：EP4384622A2

公开(公告)日：2024-06-19

申请号：EP22842773.8

申请日：2022-07-12

申请人： Mojia Biotech Pte. Ltd.

发明人： GONZALEZ, Ramon ,  CLOMBURG, James MacAllister ,  ZHU, Fayin ,  LEE, Seung Hwan ,  NEZAMIRAD, Mohammadreza

IPC分类号： C12N15/52 ,  C12N9/88 ,  C12P7/24 ,  C12P7/40 ,  C12N15/70 ,  C12P11/00

CPC分类号： Y02E50/10 ,  C12N15/74 ,  C12N15/70 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/12 ,  C12N9/13 ,  C12N9/88 ,  C12N9/1029 ,  C12N9/0093 ,  C12N9/0006

公开(公告)号：EP3688175B1

公开(公告)日：2024-03-13

申请号：EP18789532.1

申请日：2018-09-25

发明人： SANGHANI, Paresh ,  SHIUE, Eric C. ,  GREENWALT, Scott A.

IPC分类号： C12P7/04 ,  C12P7/24 ,  C12P7/40 ,  C12P7/44 ,  C12N9/04

公开(公告)号：EP4317437A1

公开(公告)日：2024-02-07

申请号：EP22779984.8

申请日：2022-03-11

申请人： Asahi Kasei Kabushiki Kaisha

发明人： ISAKA Koji ,  MIYATAKE Ryo ,  KATAYAMA Sayaka

IPC分类号： C12N15/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/31 ,  C12N15/63 ,  C12P7/02 ,  C12P7/24 ,  C12P13/00 ,  C12N15/10

摘要： There are provided a recombinant polypeptide having an excellent carboxylic acid reducing activity, and a production method of an aliphatic compound using the recombinant polypeptide.
A recombinant polypeptide has: (a) an amino acid sequence A having a sequence identity of 60% or higher, 65% or higher, 70% or higher, 75% or higher, 80% or higher, 85% or higher, 88% or higher, 90% or higher, 95% or higher, 97% or higher, 98% or higher, or 99% or higher with an amino acid sequence set forth in SEQ ID NO: 1; (b) a substitution of at least one amino acid at a position corresponding to a substrate-binding site of a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1 in the amino acid sequence A; and (c) a carboxylic acid reducing activity.

公开(公告)号：EP3317396B1

公开(公告)日：2023-10-11

申请号：EP16820600.1

申请日：2016-07-04

发明人： YAKUNIN, Alexander ,  KHUSNUTDINOVA, Anna ,  CHAN JOO, Jeong ,  MAHADEVAN, Radhakrishnan

IPC分类号： C12N1/21 ,  C12N13/00 ,  C12N15/53 ,  C12N15/54 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12P7/02 ,  C12P7/18 ,  C12P7/24 ,  C12P7/42 ,  C12P7/44

公开(公告)号：EP3022291B1

公开(公告)日：2023-06-07

申请号：EP14826331.2

申请日：2014-07-11

发明人： HANSEN, Esben Halkjaer ,  HALLWYL, Swee Chuang Lim ,  HANSEN, Klavs Riishede

IPC分类号： C12P7/24 ,  C12N9/04 ,  C12N1/21

公开(公告)号：EP4127197A1

公开(公告)日：2023-02-08

申请号：EP21714906.1

申请日：2021-03-30

申请人： Taizhou Simplu Technology Co., Ltd.

发明人： ZENG, An-Ping ,  LIU, Yongfei

IPC分类号： C12P7/18 ,  C12P7/22 ,  C12P7/24 ,  C12P7/42 ,  C12P13/04

公开(公告)号：EP4092126A1

公开(公告)日：2022-11-23

申请号：EP22164459.4

申请日：2022-03-25

申请人： INSTYTUT KATALIZY I FIZYKOCHEMII POWIERZCHNI IM.JERZEGO HABERA POLSKIEJ AKADEMII NAUK ,  PHILIPPS-UNIVERSITÄT MARBURG

发明人： Winiarska, Agnieszka ,  Szaleniec, Maciej ,  Heider, Johann ,  Hege, Dominik ,  Arndt, Fabian ,  Wojtkiewicz, Agnieszka

IPC分类号： C12P7/24 ,  C12N15/52 ,  C12N9/02

摘要： The present invention relates to a method for the enzymatic reduction of the oxidized form of nicotine adenine dinucleotide to the reduced form of nicotine adenine dinucleotide and biocatalytic method reduction of the carboxylic acids to aromatic and aliphatic aldehydes using hydrogen as reducing agent. The regioselective reduction of the substrates is carried out in an aqueous environment under a hydrogen or hydrogen containing atmosphere using enzyme preparation with tungsten aldehyde oxidoreductase (AOR) activity with an amino acid sequence of at least 70% identity to the sequence deposited in the Universal Protein database Resource Uniprot under the following gene names for subunits AorA ebA5004, AorB ebA5005 and AorC ebA5007, derived from the bacterium Aromatoleum aromaticum EbN1, or from the genetically modified bacterium A. aromaticum strain SR7 Δpdh, or from the recombinant overexpression system in Aromatoleum evansii containing a plasmid with genes coding at least the AOR enzyme (i.e. aorA, aorB, aorC genes) and potentially the gene encoding chaperone proteins (aorD and aorE).

公开(公告)号：EP3845658B1

公开(公告)日：2022-06-08

申请号：EP20000484.4

申请日：2020-12-23

发明人： Xing, Chenguang ,  Zhao, Xijing ,  Zeng, Yarou ,  LAN, Huanyan ,  LIU, Wei ,  LIU, Gang ,  Deng, Zhimin

IPC分类号： C12P7/24 ,  C12P7/22 ,  C12P39/00

公开(公告)号：EP3158069B1

公开(公告)日：2021-10-13

申请号：EP15728895.2

申请日：2015-06-17

发明人： RAMAEN, Odile ,  PANDJAITAN, Rudy ,  GELO-PUJIC, Mirjana

IPC分类号： C12N15/52 ,  C12P7/24