公开(公告)号：JPH1095757A

公开(公告)日：1998-04-14

申请号：JP18724797

申请日：1997-06-30

Applicant: ROHM & HAAS

Inventor： MICHELOTTI ENRIQUE LUIS ,  RAYLE HEATHER LYNNETTE ,  STEPHENS RANDALL WAYNE ,  ZABRODSKI WILLIAM JOSEPH

IPC: B01J31/02 ,  C07B61/00 ,  C07C51/62 ,  C07C205/57 ,  C07C205/58 ,  C07C205/59 ,  C07C231/02 ,  C07C231/04 ,  C07C233/76 ,  C07C235/44 ,  C07C237/30 ,  C07C249/08 ,  C07C251/48

Abstract: PROBLEM TO BE SOLVED: To obtain the subject antimicrobial compound by an economical method comprising reacting an acyl chloride compound with an amine compound, while reducing the number of necessary raw materials and decreasing the number of processes. SOLUTION: An acyl chloride compound of formula I (R3 , R4 , R5 are each independently a halogen, a 1-4C alkyl, amino, etc.) is reacted with an amine compound of formula II (A is a monovalent anion; R1 , R2 are each H, a 1-4C alkyl, etc.; X, Y, Z are each H, a halogen, cyano, etc.,) in the presence of an amine (e.g. triethylamine), and a chlorine atom is subsequently selectively removed from the obtained dichloroacetonyl benzamide with hydrogen in the presence of a Pd catalyst to obtain the acetonyl benzamide of formula III.

公开(公告)号：JPH11269011A

公开(公告)日：1999-10-05

申请号：JP1781599

申请日：1999-01-27

Applicant: ROHM & HAAS

Inventor： YOUNG DAVID HAMILTON ,  WILSON WILLIE J ,  EGAN ANNE R ,  MICHELOTTI ENRIQUE LUIS

IPC: A01N25/00 ,  A01N25/02 ,  A01N25/04 ,  A01N25/08 ,  A01N25/12 ,  A01N37/18 ,  A01N37/20 ,  A01N37/34 ,  A01N37/40 ,  A01N37/46 ,  A01N43/08 ,  A01N43/76 ,  A01N47/46 ,  A01N47/48 ,  A01N53/00

Abstract: PROBLEM TO BE SOLVED: To obtain a germicidal composition containing N-acetonylbenzamide and to provide a method for controlling plant pathogenic microbes with the composition. SOLUTION: This germicidal composition containing N-acetonylbenzamide contains (a) a germicidally effective amount of a first germicidally active compound having the formula (R and R are each mndependently a halogen or a 1-4C alkyl; R is a 1-4C alkyl, a 2-4C alkenyl, a 2-6C alkynyl, a 1-4C alkoxy or cyano; R and R are each independently hydrogen atom or a 1-4C alkyl and at least one of R and R is a 2-4C alkyl; X is a halogen, thiocyano or isothiocyano) or a salt acceptable to the cultivation of field crops, (b) a germicidally effective amount of a second germicidally active compound which is an acylalanine type germicide and (c) a carrier acceptable to the cultivation of the field crops.

公开(公告)号：JPH10212208A

公开(公告)日：1998-08-11

申请号：JP3240398

申请日：1998-01-30

Applicant: ROHM & HAAS

Inventor： WILLINGHAM GARY LEWIS ,  SHERBA SAMUEL EUGENE ,  LANGE BARRY CLIFFORD ,  MICHELOTTI ENRIQUE LUIS

IPC: A01N43/58 ,  C09D5/16

Abstract: PROBLEM TO BE SOLVED: To provide the subject compound useful for preventing the growth of marine life on a marine construction. SOLUTION: This compound is expressed by formula I [R is a 3-10C alkynyl, etc.; A is CR =CR -X, etc.; D is N; R is H, a 1-3C alkyl, etc.; Q is a group of formula II (R is H, a 1-6C alkoxy, etc.), etc.; X is a halogen, an alkoxy, an alkylthio, etc.], such as 6-(4-chlorophenyl)-2-(2'-pentyl)pyridazinone. A process for the production of the compound is disclosed in the European Patent 478,195 (Egan, et al). The compound is compounded in a carrier or a coating material in an amount of 0.1-30wt.% based on the object to be protected (boat, pier, fishing net, etc.) or on the coating material to be applied. In some case, a 2nd marine antifouling agent (manganese ethylenebisdithiocarbamate) is included in the agent. A marine antifouling agent having improved performance and scarcely giving adverse effect on the marine environment can be produced by this process.

公开(公告)号：JPH10114727A

公开(公告)日：1998-05-06

申请号：JP27931797

申请日：1997-09-29

Applicant: ROHM & HAAS

Inventor： MICHELOTTI ENRIQUE LUIS ,  YOUNG DAVID HAMILTON

IPC: B01J27/122 ,  C07B61/00 ,  C07C17/16 ,  C07C17/383 ,  C07C21/22 ,  C07C209/08 ,  C07C211/21

Abstract: PROBLEM TO BE SOLVED: To obtain an aminoalkyne with reduced reaction time and improved selectivity of desired amine and yield by subjecting to a process transferring an alcohol to an organic chloride and a process transferring the organic chloride to a corresponding amine. SOLUTION: (A) An alkynyl alcohol is reacted with (B) HCl to form (C) a chloroalkyne. Then, the component C is reacted with (D) a water-soluble amination agent in the presence of (E) a surfactant (preferably nonioic) to form (F) an aminoalkyne. The component F is optionally purified by a distillation. For instance, 3-amino-3-methyl-1-pentyne can be formed by using 3-methyl-1- pentyn-3-ol as the component A. By the process, amines useful for successively synthesizing a bioactive substance, e.g. a biocide product, can be prepared.

公开(公告)号：JPH10109909A

公开(公告)日：1998-04-28

申请号：JP18724597

申请日：1997-06-30

Applicant: ROHM & HAAS

Inventor： MICHELOTTI ENRIQUE LUIS ,  YOUNG DAVID HAMILTON ,  QUINN JAMES ALLEN

IPC: C07C233/76 ,  A01N37/20 ,  A01N37/44 ,  A01N37/50 ,  C07C251/48

Abstract: PROBLEM TO BE SOLVED: To enable the control of microorganisms which have gotten resistance to benzimidazole or thiophanate microbicidal agent by applying a new microbicidal agent containing a specific N-acetonylbenzamide. SOLUTION: A microbicidally effective amount of N-acetonylbenzamide of the formula (R3 -R5 are each H, carboxyl, a halo, an alkyl, an alkenyl, an alkoxy, a haloalkyl; R1 and R2 are each H, an alkyl, a haloalkyl, an alkenyl, an alkynyl; X, Y, Z are each H, a halo, thiocyano, alkylsulfonyloxy) is applied in a form a microbicidal composition. This composition preferably comprises 1-90wt.% of N-acetonylbenzamide and 90-10wt.% of a carrier which is permissible in cultivation of field crops. In addition, a microbicidal agent selected from benzimidazole, thiophanate and dicarboxyimide may be added thereto. A compound of the formula is, for example, N-(1,1-dibromo-3-methylpentane-2- on-3-yl)-3,5-dichlorobenzamide.

公开(公告)号：JP2000191411A

公开(公告)日：2000-07-11

申请号：JP36392799

申请日：1999-12-22

Applicant: ROHM & HAAS

Inventor： YOUNG DAVID HAMILTON ,  WILSON WILLIE J ,  EGAN ANNE R ,  MICHELOTTI ENRIQUE LUIS

IPC: A01N37/20 ,  A01N25/08 ,  A01N37/00 ,  A01N47/12

Abstract: PROBLEM TO BE SOLVED: To obtain the subject composition useful for controlling mildew and late blight especially caused by fungi belonging to the class Oomycetes in plants such as potato by mixing a microbicidally effective amount of a specific benzamide compound as a microbicidally active compound, etc., with a carrier. SOLUTION: This microbicidal composition comprises (A) a microbicidally effective amount of a microbicidal compound of the formula (R1, R3 are each a halogen or the like; R2 is a 1-4C alkyl or the like; R4, R5 are each a halogen, a 1-4C alkyl, provided that at least one of R4, R5 is a 2-4C alkyl; X is thiocyano or the like) or its salt acceptable on the culture of agricultural crops for example, N-[3'-(1'-chloro-3'-methyl-2'-oxopentane)]-3,5-dichloro-4-methylbenzam ide}, (B) a microbicically effective amount of a microbicidally active compound comprising 2-methyl-1-[1-(4-methylphenyl)-ethylaminocarbonyl]-propyl}-carbamic acid isopropyl ester, and (C) a carrier acceptable on the culture of agricultural crops.

公开(公告)号：JPH115705A

公开(公告)日：1999-01-12

申请号：JP14950898

申请日：1998-05-29

Applicant: ROHM & HAAS

Inventor： MICHELOTTI ENRIQUE LUIS ,  YOUNG DAVID HAMILTON

IPC: C07D233/90 ,  A01N37/18 ,  A01N37/20 ,  A01N37/34 ,  A01N37/50 ,  A01N41/04 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/34 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/42 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N47/46 ,  A01N47/48 ,  C02F1/50 ,  C07C251/48 ,  C07C331/12 ,  C07C331/20 ,  C07D209/42 ,  C07D213/81 ,  C07D215/48 ,  C07D217/26 ,  C07D231/14 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D263/56 ,  C07D275/02 ,  C07D277/20 ,  C07D277/56 ,  C07D333/38 ,  C07D333/60

Abstract: PROBLEM TO BE SOLVED: To obtain an algae-proofing agent without having defect in the any aspects of toxicity, pH, temperature-sensitivity, controlled effect, chemical stability and/or compatibility by including a specific N-acetonylarylamide derivative as an active ingredient. SOLUTION: A compound represented by formula I [A is a (substitued)phenyl, etc.; R and R are each H, a 1-6C alkyl; X, Y and Z are each H, a halo, cyano, etc.] [e.g. a compound represented by formula II (R , R and R are each cyano, etc.), formula III, formula IV, formula V (D is O or S), etc.] is included in 0.01-99.9 wt.% into a formulation (e.g. aqueous solution, hydrate or emulsion) or the compound alone is applied to algae to control algae (e.g. marine algae such as Dunaliella parva). Furthermore, the compound controls also organisms causing hard pollution on the water surface and is useful also as a marine antifouling agent.

公开(公告)号：JPH1095756A

公开(公告)日：1998-04-14

申请号：JP18724397

申请日：1997-06-30

Applicant: ROHM & HAAS

Inventor： MICHELOTTI ENRIQUE LUIS ,  YOUNG DAVID HAMILTON

IPC: A01N37/44 ,  A01N37/48 ,  A01N43/40 ,  C07C225/06 ,  C07C233/76 ,  C07C235/46 ,  C07C237/32 ,  C07C251/48 ,  C07D213/82 ,  C07D213/89

Abstract: PROBLEM TO BE SOLVED: To obtain a new compound effective for controlling phytopathogenic fungi on crops and useful for seed-protecting agents, soil-sterilizing agents, etc. SOLUTION: A compound of formula I (A is N or C-R ; R1 , R2 are each H, a 1-6C alkyl, etc.; R3 , R4 , R5 are each H, a halogen, cyano, etc.; X, Y, Z are each a halogen, cyano, thiocyano, etc.), e.g. N-(3-chloro-1-ethyl-1-methyl-2- oxopropuyl)-4-aminobenzamide. The compound of formula I is obtained by reacting a substituted benzoic acid of formula II as a starting substance with about one equivalent of methane sulfonyl chloride in the presence of a base (e.g. TEA) in a solvent such as tetrahydrofuran at -20 deg.C, adding a compound of formula III and ethylamine to the reaction product, treating the obtained N-substituted benzamide of formula IV with a halogen in the solvent mixture of e.g. methyl chloride with hexane at -78 deg.C to -10 deg.C, and subsequently hydrolyzing the obtained intermediate oxazoline hydrochloride of formula V in a solvent such as methanol at a temperature of 40-60 deg.C under an acidic condition.

公开(公告)号：JPH11310505A

公开(公告)日：1999-11-09

申请号：JP1781699

申请日：1999-01-27

Applicant: ROHM & HAAS

Inventor： YOUNG DAVID HAMILTON ,  WILSON WILLIE J ,  EGAN ANNE R ,  MICHELOTTI ENRIQUE LUIS

IPC: A01N37/18 ,  A01N37/20 ,  A01N37/40 ,  A01N47/12 ,  A01N47/46 ,  A01N47/48 ,  A01N59/20 ,  A01N59/26

Abstract: PROBLEM TO BE SOLVED: To obtain a microbicidal composition which exerts high microbicidal activity with comparatively low toxicity to plants and is particularly useful for controlling fungi belonging to oomycetes by making the composition include a specific N-acetonylbenzamide and a selected second microbicidal active compound. SOLUTION: This composition contains (A) a microbicidal effective amount of a first microbicidal active compound of the formula (R and R are each a halogen or a 1-4C alkyl; R is a 1-4C alkyl, a 2-4C alkenyl or the like; R and R are each H or a 1-4C alkyl, however, either one is a 1-4C alkyl: X is a halogen or the like) or its salt permissible on crop cultivation, (B) a microbicidal effective amount of a second microbicidal active compound selected from the group consisting of a respiratory inhibitor on cytochrome complex III, ziram, fluazinam or the like and (C) a carrier permissible on crop cultivation. For example, N-[3'-(1'-chloro-3'-methyl-2'-oxopentane)]-3,5-dichloro-4- methylbenzamide and phosphorous acid are used as the component A and the component B, respectively.

公开(公告)号：JPH1143472A

公开(公告)日：1999-02-16

申请号：JP18724697

申请日：1997-06-30

Applicant: ROHM & HAAS

Inventor： MICHELOTTI ENRIQUE LUIS ,  YOUNG DAVID HAMILTON ,  MCLAUGHLIN THOMAS ANTHONY

IPC: A01N37/18 ,  A01N37/20 ,  A01N37/34 ,  A01N43/40 ,  C07C233/76 ,  C07C235/44 ,  C07C255/57 ,  C07D213/82

Abstract: PROBLEM TO BE SOLVED: To obtain the subject composition useful as a microbicide by including a specific N-acetonyl benzamide compound and a carrier acceptable on the cultivation of field crops. SOLUTION: This composition comprises a compound of the formula (A is N, etc.; R , R are each H, a 1-6C alkyl, etc.; R is stereochemically larger than R ; R , R are each H, a 2-6C alkenyl, etc.; X, Y, Z are each cyano, etc.), [e.g. (S)-2-(3,5-dichloro-4-methylbenzoyl)-4-ethyl-4-methyl-1,3-oxazol-5-one] and a carrier capable of being accepted on the cultivation of field crops. The composition is effective for controlling a wide range of phytopathogenic fungi. The composition can be applied to the leaves of plants as a microbicidal spray, and its preferable effective amount is about 0.005-1.0 kg/hectare as the above compound.