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26 条记录 (耗时 0.039 秒)

    Novel cephem compound and its preparation
    8.
    发明专利
    Novel cephem compound and its preparation 失效
    新型化合物及其制备

    公开(公告)号：JPS59116290A

    公开(公告)日：1984-07-05

    申请号：JP22021683

    申请日：1983-11-22

    申请人： Fujisawa Pharmaceut Co Ltd

    发明人： TAKATANI TAKAO ,  MASUGI TAKASHI ,  KAWABATA KOUJI

    IPC分类号： A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/18 ,  C07D501/22 ,  C07D501/24

    CPC分类号： C07D501/22 ,  C07D501/24

    摘要： NEW MATERIAL:The compound of formula I [R
    1 is amino or acylamino; R
    2 is 2,2-dihalovinyl or ethynyl; R
    3 is (protected) carboxy] and its salt.
    EXAMPLE: 7-[ 2-Methoxyimino-2-( 2-aminothiazol-4-yl )acetamide-3-( 2,2-dichlorovinyl)-3-cephem-4-carboxylic acid (syn isomer).
    USE: Preventive and remedy for microbism.
    PROCESS: The objective compound is prepared by reducing the compound of formula II or its salt with a reducing agent comprising a combination of e.g. stannous chloride and acetyl chloride, etc., usually under cooling or at room temperature.
    COPYRIGHT: (C)1984,JPO&Japio

    摘要翻译： 新材料：式I化合物[R 1]是氨基或酰氨基; R2是2,2-二卤乙烯基或乙炔基; R 3是（保护的）羧基]及其盐。 实例：7-〔2-甲氧基亚氨基-2-（2-氨基噻唑-4-基）乙酰胺-3-（2,2-二氯乙烯基）-3-头孢烯-4-羧酸（顺式异构体）。 用途：微生物的预防和补救。 方法：目标化合物是通过用还原剂还原式II化合物或其盐来制备的，所述还原剂包括组合例如 氯化亚锡和乙酰氯等，通常在冷却或室温下。

    2-substituted cephem derivative and its preparation
    9.
    发明专利
    2-substituted cephem derivative and its preparation 失效
    2-取代的CEPHEM衍生物及其制备

    公开(公告)号：JPS5946292A

    公开(公告)日：1984-03-15

    申请号：JP15758182

    申请日：1982-09-09

    申请人： Otsuka Chem Co Ltd

    发明人： TORII SHIGERU ,  TANAKA HIDEO ,  NOGAMI JIYUNZOU ,  SASAOKA MICHIO ,  SHIROI TAKASHI ,  SAITOU NORIO

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22

    CPC分类号： C07D501/22 ,  Y02P20/55

    摘要： NEW MATERIAL:The compound of formula I [R
    1 is (substituted) phenyl(methyl) or (substituted) phenoxymethyl; R
    2 is H or carboxylic acid-protecting group; Y is allyloxy, benzyloxy, alkylthio, group of formula IIWIV (R
    4 and R
    6 are H or lower alkyl; X is O, S, etc.; R
    5 is H, lower alkyl or phenyl), etc.].
    EXAMPLE: 2-Allyloxy-7-phenoxy-acetamido-3'-desacetoxycephalosporinic acid benzyl ester of formula V.
    USE: An intermediate for the synthesis of antibacterial agent.
    PROCESS: The cephem derivative of formula VI (R
    3 is lower alkyl or acyl) is made to react with the nucleophilic agent of formula Y-H in the presence of an acid or iodine.
    COPYRIGHT: (C)1984,JPO&Japio

    摘要翻译： 新物质：式I化合物[R 1]为（取代的）苯基（甲基）或（取代的）苯氧基甲基; R 2是H或羧酸保护基; Y是烯丙氧基，苄氧基，烷硫基，式II-IV基（R 4和R 6）是H或低级烷基; X是O，S等; R 5是H，低级烷基或苯基 ）等]。 实施例：式V的2-烯丙氧基-7-苯氧基 - 乙酰氨基-3'-去乙酸基头孢菌酸苄酯。用途：合成抗菌剂的中间体。 方法：使式VI的头孢烯衍生物（R 3是低级烷基或酰基）在酸或碘的存在下与式Y-H的亲核剂反应。